Phenylketonuria (PKU) is the leading biochemical cause for mental retardation in children. The study suggests levels of tyrosine reaching the brain are directly relational to the cognitive functions in the prefrontal cortex.
Table of Contents: 1. Turner syndrome in childhood / Marsha L. Davenport, Stephen R. Hooper and Martha Zeger 2. Klinefelter syndrome / Judith L. Ross, Gerry A. Stefanatos and David Roeltgen 3. Fragile X syndrome : the journey from genes to behavior / Kimberly M. Cornish, Andrew Levitas and Vicki Sudhalter 4. Duchenne muscular dystrophy / Veronica J. Hinton and Edward M. Goldstein 5. Neurofibromatosis / John M. Slopis and Bartlett D. Moore III 6. Cognitive and behavioral characteristics of children with chromosome 22q11.2 deletion syndrome / Tony J. Simon, Merav Burg-Malki and Doron Gothelf 7. Williams Syndrome / Carolyn B. Mervis and Colleen A. Morris 8. Congenital hypothyroidism : genetic and biochemical influences on brain development and neuropsychological functioning / Joanne F. Rovet and Rosalind Brown 9. Inborn errors of metabolism / Kevin M. Antshel and Georgianne Arnold 10. Neurodevelopmental effects of childhood exposure to heavy metals : lessons from pediatric lead poisoning / Theodore I. Lidsky, Agnes T. Heaney, Jay S. Schneider and John F. Rosen 11. Beyond the diagnosis : the process of genetic counseling / Allyn McConkie-Rosell and Julianne O'Daniel 12. From diagnosis to adaptation : optimizing family and child functioning when a genetic diagnosis is associated with mental retardation / Laraine Masters Glidden and Sarah A. Schoolcraft 13. When a genetic disorder is associated with learning disabilities / Michele M. M. Mazzocco 14. Early intervention and early childhood special education for young children with neurogenetic disorders / Deborah D. Hatton 15. The individualized education program : navigating the IEP development process / Vicki Sudhalter.
The second edition of an essential resource to the evolving field of developmental cognitive neuroscience, completely revised, with expanded emphasis on social neuroscience, clinical disorders, and imaging genomics. The publication of the second edition of this handbook testifies to the rapid evolution of developmental cognitive neuroscience as a distinct field. Brain imaging and recording technologies, along with well-defined behavioral tasks—the essential methodological tools of cognitive neuroscience—are now being used to study development. Technological advances have yielded methods that can be safely used to study structure-function relations and their development in children's brains. These new techniques combined with more refined cognitive models account for the progress and heightened activity in developmental cognitive neuroscience research. The Handbook covers basic aspects of neural development, sensory and sensorimotor systems, language, cognition, emotion, and the implications of lifelong neural plasticity for brain and behavioral development. The second edition reflects the dramatic expansion of the field in the seven years since the publication of the first edition. This new Handbook has grown from forty-one chapters to fifty-four, all original to this edition. It places greater emphasis on affective and social neuroscience—an offshoot of cognitive neuroscience that is now influencing the developmental literature. The second edition also places a greater emphasis on clinical disorders, primarily because such research is inherently translational in nature. Finally, the book's new discussions of recent breakthroughs in imaging genomics include one entire chapter devoted to the subject. The intersection of brain, behavior, and genetics represents an exciting new area of inquiry, and the second edition of this essential reference work will be a valuable resource for researchers interested in the development of brain-behavior relations in the context of both typical and atypical development.
Children are widely celebrated for their imaginations, but developmental research on this topic has often been fragmented or narrowly focused on fantasy. However, there is growing appreciation for the role that imagination plays in cognitive and emotional development, as well as its link with children's understanding of the real world. With their imaginations, children mentally transcend time, place, and/or circumstance to think about what might have been, plan and anticipate the future, create fictional relationships and worlds, and consider alternatives to the actual experiences of their lives. The Oxford Handbook of the Development of Imagination provides a comprehensive overview of this broad new perspective by bringing together leading researchers whose findings are moving the study of imagination from the margins of mainstream psychology to a central role in current efforts to understand human thought. The topics covered include fantasy-reality distinctions, pretend play, magical thinking, narrative, anthropomorphism, counterfactual reasoning, mental time travel, creativity, paracosms, imaginary companions, imagination in non-human animals, the evolution of imagination, autism, dissociation, and the capacity to derive real life resilience from imaginative experiences. Many of the chapters include discussions of the educational, clinical, and legal implications of the research findings and special attention is given to suggestions for future research.
This book provides a detailed account of intellectual, other neuropsychological and behavioral manifestations of general pediatric diseases. The conditions discussed include the whole range of pediatric diseases - genetic syndromes, other congenital conditions, metabolic, endocrine, gastrointestinal, infectious, immunologic, toxic, trauma, and neoplastic, as well as sensory disabilities including deafness and blindness. Although the book is not intended to discuss cognitive and behavioral manifestations of conditions usually considered to be primary neurological disease, some of those, including cerebral palsy, muscular dystrophy, myotonic dystrophy and epilepsy, are included. Where possible, a "translational" approach is used, linking the behavioral and cognitive manifestations of these conditions, to the underlying structural, chemical or genetic abnormalities and their effect on the brain, and, in turn, on behavior and cognition. At the same time, included are significant psychosocial factors. Together, those factors have a major effect on patients' performance, including school performance, and on their families. This book is unique in its extensive coverage of the major pediatric conditions and of the detailed neurological, neuropsychological and behavioral aspects of each condition.
This volume contains the manuscripts of the full papers and posters pre sented at the conference "Dietary Phenylalanine and Brain Function," which took place at the Park Hyatt Hotel, Washington, D.C., on May 8-10, 1987. The conference was organized by a committee that included Drs. Louis Elsas (Emory University, Atlanta), William Pardridge (UCLA), Timothy Maher (Massachusetts College of Pharmacy), Donald Schomer (Harvard), and Richard Wurtman (MIT). It was sponsored by the Center for Brain Sciences and Metabolism Charitable Trust, a foun dation which, during the past few years, had also organized seven other conferences related to interactions between circulating compounds (drugs, nutrients, hormones, toxins) and brain function. The Center's most recent other conferences were on "Melatonin in Humans" (Vienna, Austria; November 1985) and "The Pharmacology of Memory Disorders Associ ated with Aging" (Zurich, Switzerland; January 1987). The decision to organize this conference was based on the perception that major changes had recently occurred in society's uses of phenylalanine and phenylalanine-containing products, and on the belief that a meeting of scientists and physicians who work on the amino acid's neurological effects could both catalyze additional research on these effects and assist regula tory bodies in formulating appropriate public policies relating to the use of these products: phenylalanine, in both its L- and D-forms, has apparently become a popular sales item at "health-food" stores, and thus is now being consumed by a fairly large number of people, in the absence of the other.
A critical part of early childhood development is the development of "theory of mind" (ToM), which is the ability to take the perspective of another person. The main purpose of this book is to discuss and integrate findings from prominent research areas in developmental psychology that are typically studied in isolation, but are clearly related. Two examples are whether executive functions represent a precursor of ToM or whether ToM understanding predicts the development of executive functions, and to what extent children's level of verbal ability and their working memory are important predictors of performance on both executive functioning and ToM tasks. The chapters in this book give a detailed account of the major outcomes of this research. First, the state of the art concerning current understanding of the relevant constructs (working memory, ToM, executive functioning) and their developmental changes is presented, followed by chapters that deal with interactions among the core concepts. Its main focus is on theoretically important relationships among determinants of young children's cognitive development--considered to be "hot" issues in contemporary developmental psychology. Based on presentations made at an international workshop, this book is divided into two parts. In the first part, five teams of researchers present theoretical analyses and overviews of empirical evidence regarding the core constructs of memory, executive functions, and ToM. The next part deals with the interplay among the core concepts outlined in Part I with developmental trends in the interaction.
This all-embracing Handbook on the Development of Children’s Memory represents the first place in which critical topics in memory development are covered from multiple perspectives, from infancy through adolescence. Forty-four chapters are written by experienced researchers who have influenced the field. Edited by two of the world’s leading experts on the development of memory Discusses the importance of a developmental perspective on the study of memory The first ever handbook to bring together the world’s leading academics in one reference guide Each section has an introduction written by one of the Editors, who have also written an overall introduction that places the work in historical and contemporary contexts in cognitive and developmental psychology 2 Volumes
This book reviews the latest techniques in exploratory data mining (EDM) for the analysis of data in the social and behavioral sciences to help researchers assess the predictive value of different combinations of variables in large data sets. Methodological findings and conceptual models that explain reliable EDM techniques for predicting and understanding various risk mechanisms are integrated throughout. Numerous examples illustrate the use of these techniques in practice. Contributors provide insight through hands-on experiences with their own use of EDM techniques in various settings. Readers are also introduced to the most popular EDM software programs. A related website at http://mephisto.unige.ch/pub/edm-book-supplement/offers color versions of the book’s figures, a supplemental paper to chapter 3, and R commands for some chapters. The results of EDM analyses can be perilous – they are often taken as predictions with little regard for cross-validating the results. This carelessness can be catastrophic in terms of money lost or patients misdiagnosed. This book addresses these concerns and advocates for the development of checks and balances for EDM analyses. Both the promises and the perils of EDM are addressed. Editors McArdle and Ritschard taught the "Exploratory Data Mining" Advanced Training Institute of the American Psychological Association (APA). All contributors are top researchers from the US and Europe. Organized into two parts--methodology and applications, the techniques covered include decision, regression, and SEM tree models, growth mixture modeling, and time based categorical sequential analysis. Some of the applications of EDM (and the corresponding data) explored include: selection to college based on risky prior academic profiles the decline of cognitive abilities in older persons global perceptions of stress in adulthood predicting mortality from demographics and cognitive abilities risk factors during pregnancy and the impact on neonatal development Intended as a reference for researchers, methodologists, and advanced students in the social and behavioral sciences including psychology, sociology, business, econometrics, and medicine, interested in learning to apply the latest exploratory data mining techniques. Prerequisites include a basic class in statistics.