Physical Principles and Techniques of Protein Chemistry Part B

Physical Principles and Techniques of Protein Chemistry Part B

Author: Sydney Leach

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 508

ISBN-13: 0323141137

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Physical Principles and Techniques of Protein Chemistry, Part B deals with the theories and application of selected physical methods in protein chemistry evaluation. This book is divided into seven chapters that cover the ultracentrifugal analysis, light scattering, infrared (IR) methods, nuclear magnetic resonance (NMR) spectroscopy, and differential thermal analysis of protein properties. This text first describes the fundamental ideas and methodology of sedimentation analysis of ideal noninteracting solutes and the problems of nonideality and solute-solute interaction. This book then deals with the problems involved in the interpretation of viscometric data for evaluation of intrinsic viscosity of proteins. The following chapters examine the principles, measurement and analysis of spectra, and experimental techniques of light scattering, IR, and NMR spectroscopic methods. Discussions on coordination phenomena, identification of binding sites, and ion binding in the crystalline state and in protein solutions are included. The concluding chapter presents some examples of protein analysis using differential thermal analysis technique. This book is of great value to chemists, biologists, and researchers who have great appreciation of protein chemistry.


Physical Principles and Techniques of Protein Chemistry Part C

Physical Principles and Techniques of Protein Chemistry Part C

Author: Sydney Leach

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 639

ISBN-13: 0323141145

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Physical Principles and Techniques of Protein Chemistry, Part C focuses on the effects of intermolecular interactions that are transmitted between ligands and proteins and from protein to protein. This book discusses the density and volume change measurements; direct volume change; osmotic pressure; and small-angle X-ray scattering. The theory of particulate scattering; pulsed nuclear magnetic resonance; absorption of water by diamagnetic molecules; and use of least squares in data analysis are also elaborated. This text likewise covers the iteration process; optical rotatory dispersion and the main chain conformation of proteins; and basic relations for optically active molecules. Other topics include the circular dichroism, secondary structure of proteins, visible rotatory dispersion, and peptide cotton effects. This publication is intended for protein chemists, but is also useful to biologists, medical practitioners, and students researching on protein chemistry.


Physical Principles and Techniques of Protein Chemistry Part A

Physical Principles and Techniques of Protein Chemistry Part A

Author: Sydney Leach

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 545

ISBN-13: 0323141129

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Physical Principles and Techniques of Protein Chemistry, Part A deals with the principles and application of selected physical methods in protein chemistry evaluation. This book is organized into nine chapters that cover microscopic, crystallographic, and electrophoretic techniques for protein conformational perturbations evaluation. This text first presents a general account of electron microscopy, its specimen preparation, optimum conditions for high resolution, measurement of electron micrographs, and illustrative examples of protein study. This book then examines the different types of maps from X-ray methods and the diffraction data from fibrous proteins. The subsequent chapters cover discussions on UV spectroscopy of proteins; luminescence properties of proteins and related compounds; and perturbation and flow methods for evaluation of proteins' dynamic properties and rate constants. Other chapters deal with the evaluation of proteins' dielectric properties using dielectric relaxation, electric birefringence, and dichroism techniques. The concluding chapters outline the theoretical and experimental advances of the electrophoretic and gel filtration methods for the study of protein structure and molecular weight. This book is of great value to chemists, biologists, and researchers who have great appreciation of protein chemistry.


The Plasma Proteins

The Plasma Proteins

Author: Frank W Putnam

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 498

ISBN-13: 032313808X

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The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume I is a systematic account of the structure, function, and genetic control of plasma proteins. Clinical relevance is introduced in terms of principles, with emphasis on human proteins. Animal proteins are also used as examples in some cases. Comprised of nine chapters, this volume begins with a historical background on plasma proteins, along with their nomenclature, characterization, and genetic markers. The primary structure and three-dimensional conformation of plasma proteins are also considered. The discussion then turns to the chemical, physical, and biological properties of various plasma proteins such as serum albumin, lipoproteins, and immunoglobulins. Subsequent chapters deal with protease inhibitors in plasma; purification, physical properties, chemical composition, and molecular structure of transferrin; biosynthesis and metabolism of serum lipoproteins; and physical, chemical, and functional properties of the proteins of the complement system. The final chapter is devoted to ?2-microglobulin, with particular reference to its purification and physical properties; chemical composition and structure; physiological function, biosynthesis, and catabolism; and presence and function in cell membranes. This monograph will be of interest to molecular biologists and biochemists.


The Lennox Legacy

The Lennox Legacy

Author: DE Rivett

Publisher: CSIRO PUBLISHING

Published: 1996-01-01

Total Pages: 365

ISBN-13: 0643105778

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The Lennox Legacy: The history of the CSIRO Laboratory at 343 Royal Parade Parkville records many of the events and incidents associated with the genesis and development of the Division of Protein Chemistry over a period of more than fifty years. This book has been titled in honour of Dr Francis Gordon Lennox, the Laboratory's founder and a man who believed that science has an important part to play in bettering the well-being of all Australians. His vision, over the years, of the critical importance of protein chemistry to Australian science and industry, was central to the Laboratory's national and international achievements. The book has been written three parts: *Part 1 attempts to trace the historical record of appointments and changes in research direction that have occurred in the laboratory from 1940 to the present day. *Part 2 presents a more detailed description of the major scientific activities that have been carried out in the Laboratory. It reveals how fundamental studies went hand-in-hand with applied research and thereby contributed greatly to the understanding of practical problems and their possible solution. *Part 3 provides a complete list of Patents and Publications arranged in decades for easy perusal. As former chief Gordon Crewther states in his foreword: "Of necessity, the story is incomplete, but because it records the stresses, exhilarations, frustrations, rewards, good fellowship, team spirit, irritations and humourous interludes arising from the research objectives of the Division and their accomplishment, there is something of interest for all present and past members of staff of CSIRO. The less technical sections, the occasional insights into/behind the scenes' activities, the glimpses of individual personalities, and the occasional reflections on science management, provides worthwhile reading for a more general audience."