Acute Ischemic Stroke
Acute Ischemic Stroke

Author: R. Gilberto González

Publisher: Springer Science & Business Media

Published: 2010-10-05

Total Pages: 299

ISBN-13: 3642127517

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This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.

Cerebral Small Vessel Disease
Cerebral Small Vessel Disease

Author: Leonardo Pantoni

Publisher: Cambridge University Press

Published: 2014-05

Total Pages: 375

ISBN-13: 1107031664

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Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.

Clinical Pharmacology of Cerebral Ischemia
Clinical Pharmacology of Cerebral Ischemia

Author: Gert J. Ter Horst

Publisher: Springer Science & Business Media

Published: 1996-11-01

Total Pages: 309

ISBN-13: 1592594727

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A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting. These leading basic and fundamental authorities survey such important new drugs as calcium-influx inhibitors, free-radical scavenging drugs, glutamate and glycinergic antagonists, and immune suppressors. They also evaluate all the latest findings concerning calcium homeostasis, glutamate toxicity, gene activation, and the role of free radicals, glycine, and hormones. Chapters devoted to the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation complete this informative collection of cutting-edge reviews.

Handbook of Neuroemergency Clinical Trials
Handbook of Neuroemergency Clinical Trials

Author: Brett E. Skolnick

Publisher: Academic Press

Published: 2017-11-13

Total Pages: 408

ISBN-13: 0128041013

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Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development. - Presents a comprehensive overview on clinical trials and drug development challenges in acute neuroscience populations - Provides neurologists, neuroscientists and drug developers with a complete understanding of scientific and medical issues related to designing clinical trials - Edited by leaders in the field who have designed and managed over 50 neuroemergency clinical trials

Core Topics in Neuroanaesthesia and Neurointensive Care
Core Topics in Neuroanaesthesia and Neurointensive Care

Author: Basil F. Matta

Publisher: Cambridge University Press

Published: 2011-10-13

Total Pages: 535

ISBN-13: 1139499858

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Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.

Stroke Therapy
Stroke Therapy

Author: Marc Fisher

Publisher: Butterworth-Heinemann

Published: 2001

Total Pages: 432

ISBN-13:

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This new edition keeps you up to date with the exciting new developments in treating cerebrovascular disorders. Comprehensive and practical, it surveys methods for accurate stroke diagnosis necessary for you to make appropriate therapeutic decisions.

Transient Ischemic Attack and Stroke
Transient Ischemic Attack and Stroke

Author: Sarah T. Pendlebury

Publisher: Cambridge University Press

Published: 2009-02-19

Total Pages: 407

ISBN-13: 0521735122

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Accessible handbook covering the investigation, diagnosis and management of transient ischemic attacks and minor strokes.

Brain Hypothermia
Brain Hypothermia

Author: N. Hayashi

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 253

ISBN-13: 4431668829

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Rapid progress in technology and its application to diagnosis and monitoring of brain tissue temperature and metabolism have resulted in advances in the therapy for critically brain-injured patients and breakthroughs in understanding the pathophysiology of brain damage. The latest concept of brain hypothermia therapy clarifies targets such as brain thermal pooling, masking brain hypoxia associated with catecholamine surge, the metabolic shift from glucose to lipids, and selective radical damage of dopamine in the central nervous system. This volume explains the mechanism of brain injury and how brain hypothermia treatment differs from other hypothermia therapy in four major sections: Brain Injury Mechanism, Pathophysiology of Hypothermia, Basic Research of Hypothermia Treatment, and Clinical Studies of Brain Hypothermia. The book is a valuable source for practitioners and researchers in neurosurgery and neurology and in critical care and emergency medicine.