Pharmacokinetics Made Easy 1Rpresents the complex subject of pharmacokinetics in a simple, easy-to-understand manner, lending itself to a wide audience including medical practitioners, health professionals and students of pharmacology, medicine and nursing. The physiological approach adopted in the book allows clinical issues in drug therapy to be addressed, making it directly applicable to practice situations. The chapters in this book were initially published as a series of articles inAustralian Prescriberto assist practitioners in drug dosing and therapy. In this revised edition, the book has been updated according to recent developments and a new chapter called 'How to Determine the Pharmacokinetic Parameters of a Drug' added. Each chapter also has a new feature-a list of key points summarising the content to improve accessibility and understanding.
The book blendes the essentials of basic pharmacology and clinical pharmacology so that the transition from classroom to hospital is less abrupt. Students report that the book is most effective when lecture notes are written directly on the tables and margins, providing a single, concise guide for finals and the National Boards.
With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
**Textbook and Academic Authors Association (TAA) Most Promising New Textbook Award Winner, 2024** Master the pharmacology essentials that health professionals need in practice! Pharmacology Made Simple: An Introduction for the Health Professions makes it easy to understand and apply pharmacology concepts in healthcare careers. Clear and concise, this text uses colorful illustrations, case scenarios, and memory devices to simplify learning and review questions to aid comprehension. An Evolve companion website includes animations of body systems, two practice exams for more self-testing, and printable drug tables. This exciting and practical new text helps you build professional skills and ensures your readiness for the workplace. - Essential information is logically organized and easy to read, focusing on what you need to know. - Engaging, reader-friendly format breaks down pharmacology into manageable chunks of information, accompanied by "flashcard" boxes and memory devices. - Mini case studies in each chapter demonstrate real-world healthcare applications, with scenarios from a variety of health professions settings. - Chapter review questions provide opportunities to assess your comprehension as you move forward. - Full-color illustrations bring complex pharmacology concepts to life with realistic figures and drawings. - Clinical Application and Alert features stress critical thinking and effective job preparation. - Scenario and Alert features stress clinical application and safety. - Focus on patient education helps you learn and practice key skills in professionalism. - Chapter key terms and back-of-book glossary includes pharmacology terms cross-referenced to the chapters in which they are introduced and discussed. - Additional learning resources include a study guide (available separately) and an Evolve companion website with animations, practice exams, and more. - Chapter objectives guide your study by listing the chapter's most important concepts.
Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpu Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpufConcepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf
Get all the basics on drug therapies—and administer drugs confidently and accurately—with the newly updated Pharmacology Made Incredibly Easy, 4th Edition. Written in the enjoyable, award-winning Incredibly Easy style, this easy-to-follow, fully illustrated guide offers step-by-step direction on the medication process, from assessing patient needs, to planning care, to implementation and positive outcomes. Strengthen your understanding of your class materials, get ready for the NCLEX® or certification exam, and administer drug therapies—safely and effectively! Build a strong platform of pharmacology knowledge and skills with. . . NEW and updated content on the newest approved medications and dosages and NEW tables listing: NEW vaccines and treatment for biological weapons exposure NEW treatment and antidotes for chemical weapons exposure NEW herbal drugs content NEW icons and images that clarify content Revised and updated content on the concepts of pharmacokinetics, pharmacodynamics, and pharmacotherapeutics Pharmacology basics – How drugs are derived, developed, classified, and administered; classes of drugs by body system; their uses and mechanisms “Nurse Joy” and “Nurse Jake” illustrated characters offering tips and insights throughout Quick-scan format with concise, bulleted content Hundreds of illustrations and diagrams explaining key concepts and providing clear direction on administering drugs; drug distribution, absorption, and metabolism; potential drug interactions; adverse reactions; how different classes of drugs work in different body systems Special chapter features: Just the facts – A quick summary of chapter content Advice from the experts – Experienced practitioners’ insights Prototype pro – Actions, indications, and nursing considerations for common prototype drugs Nursing process – Patient assessment, diagnosis, outcome goals, implementation, and evaluation for each type and class of drug Pharm function – Illustrating how drugs act in the body; recognizing and treating adverse reactions Before you give that drug – Warnings to consider before you administer a drug Education edge – Information to share with your patient Quick quiz – End-of-chapter questions with answers/explanations, to help you remember the essentials End-of-book multiple-choice Q&A; Quick Guides to Medication Safety, Ophthalmic and Dermatologic Drugs, and Abbreviations to Avoid; Glossary of essential pharmacology terms.
Written in the award-winning Incredibly Easy! style, this book provides complete and clear explanations of how drugs act and interact in the treatment of disease. Focusing on mechanisms of drug action, the book details specific drugs by pharmacologic class for all body systems as well as drugs for pain, psychiatric disorders, infection, fluid and electrolyte imbalances, and cancer. Potentially dangerous drug and drug-herb interactions are highlighted. This thoroughly updated edition covers the newest drugs in each pharmacologic class and includes information on obesity drugs, a new chapter on genitourinary system drugs, a new medication safety feature, and a new appendix on common herbal preparations and their drug interactions.
Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
