Pesticide Dose

Pesticide Dose

Author: Stephen Duke

Publisher: ACS Symposium

Published: 2018-06-04

Total Pages: 208

ISBN-13: 9780841232112

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Pesticide dose is a parameter that is central to pesticide efficacy, effects of pesticides on non-target organisms, evolution of pesticide resistance, and non-intended pesticide effects such as hormesis (the stimulatory effect of a sub-toxic dose of a toxin). This book details and documents the reasons why only a tiny fraction of applied pesticides reach their desired molecular targets in the pests for which they are intended. This is followed by a discussion of the relationship of dose to efficacy levels and the practical implications of this. Pesticide movement to non-target organisms by drift and other processes has become a topic of great interest and is thoroughly covered. The book ends with a review of the effects of herbicides on non-target terrestrial plants with large differences in sensitivities to low herbicides doses. This volume gives the reader an appreciation for the complexity of pesticide dose effects.


Pesticides in the Diets of Infants and Children

Pesticides in the Diets of Infants and Children

Author: National Research Council

Publisher: National Academies Press

Published: 1993-02-01

Total Pages: 402

ISBN-13: 0309048753

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Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.


Intentional Human Dosing Studies for EPA Regulatory Purposes

Intentional Human Dosing Studies for EPA Regulatory Purposes

Author: National Research Council

Publisher: National Academies Press

Published: 2004-06-04

Total Pages: 226

ISBN-13: 0309166411

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The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.


Pesticide Resistance

Pesticide Resistance

Author: National Research Council

Publisher: National Academies Press

Published: 1986-02-01

Total Pages: 484

ISBN-13: 0309036275

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Based on a symposium sponsored by the Board on Agriculture, this comprehensive book explores the problem of pesticide resistance; suggests new approaches to monitor, control, or prevent resistance; and identifies the changes in public policy necessary to protect crops and human health from the ravages of pests. The volume synthesizes the most recent information from a wide range of disciplines, including entomology, genetics, plant pathology, biochemistry, economics, and public policy. It also suggests research avenues that would indicate how to counter future problems. A glossary provides the reader with additional guidance.


Regulating Pesticides in Food

Regulating Pesticides in Food

Author: National Research Council

Publisher: National Academies Press

Published: 1987-02-01

Total Pages: 288

ISBN-13: 0309037468

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Concern about health effects from exposure to pesticides in foods is growing as scientists learn more about the toxic properties of pesticides. The Delaney Clause, a provision of the Food, Drug and Cosmetic Act, prohibits tolerances for any pesticide that causes cancer in test animals or in humans if the pesticide concentrates in processed food or feeds. This volume examines the impacts of the Delaney Clause on agricultural innovation and on the public's dietary exposure to potentially carcinogenic pesticide residues. Four regulatory scenarios are described to illustrate the effects of varying approaches to managing oncogenic pesticide residues in food.


Neurotoxicity of Pesticides

Neurotoxicity of Pesticides

Author:

Publisher: Academic Press

Published: 2020-03-21

Total Pages: 288

ISBN-13: 0128205156

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Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Organophosphates, OPs, Nerve agents, Pyrethroids, Neonicotinoids and Formamidines, among others.


Pesticides

Pesticides

Author: Marvin J. Levine

Publisher: Bloomsbury Publishing USA

Published: 2007-03-30

Total Pages: 265

ISBN-13: 0313082197

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Pesticide exposure has long been a cause for concern, and with good reason. Studies have shown that all persons, but especially children, pregnant women, farmers, farmworkers, and the elderly, may experience negative health effects from pesticide exposure. These effects may include acute poisoning, cancer, neurological damage, birth defects, reduced sperm count, suppressed immune systems, and reproductive and developmental harm. This book is a comprehensive examination of pesticide use, pesticide harm, and alternatives to harmful pesticides. Levine highlights the role of farming, because a substantial majority—70 percent or more annually—of pesticides are applied in agricultural uses, thereby making their way into the food chain and into the water supply. More than 20 types of pesticides have been detected in U.S. groundwater, and it is believed that nearly 100 have the potential to invade our municipal water systems. Some level of pesticide contamination has been detected in every state, in both urban and agricultural areas. Outside of agriculture, people are exposed to pesticides primarily in the home. Approximately 90 percent of all households in the nation use pesticides, and the number and concentration of these agents indoors has been shown to be greater than outdoors. Given that Americans now spend nearly 90 percent of each day indoors, this is an issue of real concern. In addition to homes, suburban and rural corporate parks are also affected. Schools are another worrisome venue. In too many of our 110,000 school districts, untrained persons are making critical decisions about the use of pesticides in school buildings and on school grounds. No other book currently examines this issue in such breadth and depth.


Occupational Hazards Of Pesticide Exposure

Occupational Hazards Of Pesticide Exposure

Author: Donald J. Ecobichon

Publisher: CRC Press

Published: 2020-08-12

Total Pages: 268

ISBN-13: 1000162966

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With three million intoxications a year, global concern about occupational exposure to pesticides makes it crucial that occupational health professionals be able monitor pesticide exposure. With a useful analysis of the advantages and disadvantages of classic and modern techniques, Occupational Hazards of Pesticide Exposure permits professionals to undertake these tasks with techniques best suited to a given situation. Includes descriptions and examples of how to: o Quantify aerial drift of pesticide sprays o Determine on-target/off-target loss of pesticide o Measure disposition of pesticides on surfaces o Detect translocation of residues for air and surfaces to skin o Measure absorption through the skin o Quantify residues or metabolites in biological fluids o Determine the extent of neurological impairment