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Author: Douglas W. Zochodne
Publisher:
Published: 2008
Total Pages: 276
ISBN-13: 9780511437809
DOWNLOAD EBOOKOf what peripheral nerves are, how they can be damaged, and the sequence of events involved in their regeneration.
Author: James B. Phillips
Publisher: Springer
Published: 2022-05-26
Total Pages: 612
ISBN-13: 9783030210519
DOWNLOAD EBOOKThis updatable book provides an accessible informative overview of the current state of the art in nerve repair research.The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.
Author: Giovanna Gambarotta
Publisher: Frontiers Media SA
Published: 2019-12-24
Total Pages: 302
ISBN-13: 2889632687
DOWNLOAD EBOOKAuthor: Ana Colette Maurício
Publisher: BoD – Books on Demand
Published: 2017-05-31
Total Pages: 226
ISBN-13: 9535131656
DOWNLOAD EBOOKPeripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.
Author: Christopher J. Dy
Publisher: Springer Nature
Published: 2021-11-15
Total Pages: 431
ISBN-13: 3030844285
DOWNLOAD EBOOKPeripheral nerve issues are potential sequalae of orthopedic surgery, even after cases in which technically excellent surgery was performed. These injuries can impede the expected recovery of function after the primary surgery. Given the manifold challenges associated with recovery of peripheral nerve injuries, this book is designed as a multidisciplinary guide to the diagnosis, prognostication and treatment of peripheral nerve issues after common orthopedic surgeries. Beginning with an overview of nerve compression, injury and regeneration, as well as a presentation of the current diagnostic and imaging modalities for peripheral nerve injuries, this unique text is organized by anatomic region and by type of procedure performed. Topics covered include shoulder and elbow arthroplasty and arthroscopy, fractures of the hand and wrist, hip preservation surgery, total knee replacement, open surgery of the foot and ankle, lumbosacral myeloradiculopathy, and more. Each chapter is authored by both a subspecialty surgeon who routinely performs the surgeries described and a subspecialized hand/peripheral nerve surgeon with experience in evaluating and treating nerve issues after that particular injury. Emphasis is placed on multidisciplinary team approaches, patient counseling, and technical aspects of surgical treatment. Generously illustrated and written by experts in the field, Peripheral Nerve Issues after Orthopedic Surgery is a truly interdisciplinary resource for orthopedic, plastic, hand and trauma surgeons, physiatrists, trainees, and all professionals evaluating and managing postoperative peripheral nerve issues.
Author: Rolfe Birch
Publisher: Springer Science & Business Media
Published: 2012-11-15
Total Pages: 278
ISBN-13: 1447146131
DOWNLOAD EBOOK Peripheral Nerve Injuries: A Clinical Guide is a fully illustrated and informative reference on injuries within the peripheral nervous system. It incorporates new knowledge in molecular and cellular events which underlie the response of nerves to injury, regeneration and neuropathic pain. Written by a leading expert in the field, Peripheral Nerve Injuries: A Clinical Guide, is a valuable resource for surgeons in residence and training.
Author: Stefano Geuna
Publisher: Academic Press
Published: 2009-08-10
Total Pages: 603
ISBN-13: 012378574X
DOWNLOAD EBOOKInterest in the study of peripheral nerve repair and regeneration has increased significantly over the last twenty years and today the number of nerve reconstructions performed is progressively increasing due to the continuous improvement in surgical technology and to the spread of microsurgical skills among surgeons worldwide. This volume of International Review of Neurobiology providdes an overview of the state of the art knowledge in peripheral nerve repair and regeneration by bringing together a number of reviews that critically address some the most important issues in this biomedical field.
Author: Norman Saunders
Publisher: CRC Press
Published: 2003-09-02
Total Pages: 354
ISBN-13: 0203304489
DOWNLOAD EBOOKDegeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
Author: Xiaobing Fu
Publisher: Springer
Published: 2018-02-09
Total Pages: 296
ISBN-13: 3662561794
DOWNLOAD EBOOKThis book focuses on the contribution of cell dedifferentiation to the regenerative process in all body systems, as well as its underlying molecular mechanisms and applications. The book is divided into four parts, the first of which addresses the history of cell dedifferentiation and regenerative medicine. In turn, Part II compares three routes by which cells change their phenotype: dedifferentiation, transdifferentiation, and reprogramming. Part III includes an extensive review of cell dedifferentiation events in all nine body systems for lower organisms and mammalians, respectively. The final part reviews the relationship between cell dedifferentiation and the development of cancer and several other diseases, while also outlining the prospects of and future research directions in cell dedifferentiation and regenerative medicine. The main purpose of the book is to underline the importance of cell dedifferentiation in stem cell and regenerative medicine by providing a systematical review of dedifferentiation in all body systems, together with the latest reliable evidence.
Author: Göran Lundborg
Publisher:
Published: 1988-01-01
Total Pages: 222
ISBN-13: 9780443035289
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