Peptide Receptors, Part II
Peptide Receptors, Part II

Author: A. Bjorklund

Publisher: Elsevier

Published: 2002-12-13

Total Pages: 441

ISBN-13: 0080538576

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Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complementwith chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry.Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.

Peptide Receptors, Part II
Peptide Receptors, Part II

Author: A. Bjorklund

Publisher: Elsevier Science

Published: 2002-12-13

Total Pages: 0

ISBN-13: 9780444505408

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Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complementwith chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry. Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.

Peptide Receptors, Part I
Peptide Receptors, Part I

Author: A. Bjorklund

Publisher: Elsevier

Published: 2000-06-08

Total Pages: 537

ISBN-13: 0080538584

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During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information. Peptide Receptors Part I summarizes current knowledge on ten distinct peptide families. This volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry, and immunocytochemistry images. Application of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system. The functional role of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders.

Janeway's Immunobiology
Janeway's Immunobiology

Author: Kenneth Murphy

Publisher: Garland Science

Published: 2010-06-22

Total Pages:

ISBN-13: 9780815344575

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The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

An Introduction to Neuroendocrinology
An Introduction to Neuroendocrinology

Author: Richard E. Brown

Publisher: Cambridge University Press

Published: 1994-01-27

Total Pages: 434

ISBN-13: 9780521426657

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This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.

Relaxin and Related Peptides
Relaxin and Related Peptides

Author: Alexander I. Agoulnik

Publisher: Springer Science & Business Media

Published: 2008-12-19

Total Pages: 161

ISBN-13: 0387746722

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This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.

Handbook of Cell Signaling
Handbook of Cell Signaling

Author: Ralph A. Bradshaw

Publisher: Academic Press

Published: 2009-11-03

Total Pages: 3188

ISBN-13: 0080920918

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Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field

Peptide Chemistry and Drug Design
Peptide Chemistry and Drug Design

Author: Ben M. Dunn

Publisher: John Wiley & Sons

Published: 2015-02-02

Total Pages: 336

ISBN-13: 1118995287

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This book focuses on peptides as drugs, a growing area ofpharmaceutical research and development. It helps readers solveproblems of discovering, developing, producing, and deliveringpeptide-based drugs. • Identifies promising new areas in peptide drugdiscovery • Includes chapters on discovery from natural sources,metabolic modification, and drug delivery • Overviews separation methods and techniques foranalysis, bond formation, and purification • Offers readers both a professional reference and atext or resource for graduate-level students

Peptide-based Drug Discovery
Peptide-based Drug Discovery

Author: Ved Srivastava

Publisher: Royal Society of Chemistry

Published: 2017-06-26

Total Pages: 589

ISBN-13: 1782627324

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With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.