Paediatric drug optimization for antibiotics
Author: World Health Organization
Publisher: World Health Organization
Published: 2023-03-22
Total Pages: 27
ISBN-13: 9240068937
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Paediatric Formulation
Author: Nunzio Denora
Publisher: MDPI
Published: 2021-09-02
Total Pages: 205
ISBN-13: 303650740X
DOWNLOAD EBOOKThe development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Model-Based Evaluation of Antimicrobial Agents in Children
Author: Wei Zhao
Publisher: Frontiers Media SA
Published: 2021-10-01
Total Pages: 160
ISBN-13: 2889714500
DOWNLOAD EBOOKTopic Editor Johannes N. van den Anker is the Chief Medical Officer at Reveragen Biopharma, as well as holding his positions at academic institutions. The other Topic Editor declares no competing interests with regard to the Research Topic subject.
Antibiotic Pharmacodynamics
Author: John C. Rotschafer
Publisher: Humana
Published: 2016-03-30
Total Pages: 0
ISBN-13: 9781493933211
DOWNLOAD EBOOKThis text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.
Paediatric Clinical Pharmacology
Author: Evelyne Jacqz-Aigrain
Publisher: CRC Press
Published: 2021-02-25
Total Pages: 830
ISBN-13: 0849374448
DOWNLOAD EBOOKThe treatment of children with medicinal products is an important scientific area. It is recognized that many medicines that are used extensively in pediatric patients are either unlicensed or off-label. This textbook will help pediatric health professionals effectively treat children with the most appropriate medicine with minimal side effects.
Manual of Childhood Infections
Author: Mike Sharland
Publisher: Oxford University Press, USA
Published: 2011-04-07
Total Pages: 913
ISBN-13: 0199573581
DOWNLOAD EBOOKThis manual gives information on the causative organisms, epidemiology and clinical features of all important childhood infections. It includes guidance on the clinical management of the infections and on steps to be taken to prevent future cases.
Paediatric drug optimization for neglected tropical diseases
Author: World Health Organization
Publisher: World Health Organization
Published: 2023-11-21
Total Pages: 56
ISBN-13: 9240085173
DOWNLOAD EBOOKPriority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations in clinical trials and/or lack of age-appropriate dosing regimens and formulations. The PADO-NTD exercise concluded with a final meeting organized in September 2023 with representatives from the four prioritized disease areas to reach consensus on a final PADO-NTD priority list, watch list and research questions and discuss transversal issues for the way forward. The meeting report will include summaries of the background, discussions and deliberations of all PADO exercises, and final conclusions and outputs of the overall PADO for NTD exercises.
Paediatric drug optimization for cancer medicines
Author: World Health Organization
Publisher: World Health Organization
Published: 2024-10-16
Total Pages: 33
ISBN-13: 9240101055
DOWNLOAD EBOOKThe goal of the Paediatric drug optimization for cancer exercise was to develop a PADO priority list of formulations to be prioritized with a time horizon of 3–5 years, and a PADO ‘watch list’ containing promising candidates for investigation and development for children with a time horizon of 5–10 years. The PADO–cancer exercise enables alignment between funders, procurers, market-coordination entities, researchers, innovators, generics manufacturers, product development partnerships and regulators on priority products to be investigated and developed, as well as increasing efforts to tackle challenges in access to cancer medicines in LMICs.
Drug Delivery Approaches
Author: Bret Berner
Publisher: John Wiley & Sons
Published: 2021-08-31
Total Pages: 466
ISBN-13: 1119772737
DOWNLOAD EBOOKExplore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Antimicrobial Stewardship
Author: Matthew Laundy
Publisher: Oxford University Press
Published: 2016
Total Pages: 177
ISBN-13: 0198758790
DOWNLOAD EBOOKAntibiotic resistance threatens the effective prevention and treatment of infections. Antimicrobial Stewardship provides a practical guide on this growing area, supported by the review of the available evidence, including example case studies.
