Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Author: Sajal Chakraborti

Publisher: Springer Nature

Published: 2022-09-28

Total Pages: 4078

ISBN-13: 9811654220

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This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Novel Therapeutic Approaches Targeting Oxidative Stress
Novel Therapeutic Approaches Targeting Oxidative Stress

Author: Pawan Kumar Maurya

Publisher: Academic Press

Published: 2022-02-18

Total Pages: 294

ISBN-13: 032390906X

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Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer's and Parkinson's disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives. - Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer - Covers a range of therapeutic approaches to target oxidative stress - Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress - Features case studies illustrating the targeting of oxidative stress

The Heterogeneity of Cancer Metabolism
The Heterogeneity of Cancer Metabolism

Author: Anne Le

Publisher: Springer

Published: 2018-06-26

Total Pages: 186

ISBN-13: 331977736X

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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Mitochondria and Cancer
Mitochondria and Cancer

Author: Keshav Singh

Publisher: Springer Science & Business Media

Published: 2009-04-05

Total Pages: 294

ISBN-13: 0387848355

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Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Cancer
Cancer

Author: Victor R Preedy

Publisher: Academic Press

Published: 2014-03-01

Total Pages: 325

ISBN-13: 0124055249

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Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this. Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer. - Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease - Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments - Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams - Nutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods

Oxidative Stress in Cancer Biology and Therapy
Oxidative Stress in Cancer Biology and Therapy

Author: Douglas R. Spitz

Publisher: Springer Science & Business Media

Published: 2011-11-25

Total Pages: 465

ISBN-13: 1617793973

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During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Oxidative Stress and Redox Regulation
Oxidative Stress and Redox Regulation

Author: Ursula Jakob

Publisher: Springer Science & Business Media

Published: 2013-03-15

Total Pages: 488

ISBN-13: 9400757875

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Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Ovarian Cancer
Ovarian Cancer

Author: Omer Devaja

Publisher: BoD – Books on Demand

Published: 2018-10-24

Total Pages: 366

ISBN-13: 1789843332

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Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Oxidative Stress and Chronic Degenerative Diseases
Oxidative Stress and Chronic Degenerative Diseases

Author: Jose Antonio Morales-Gonzalez

Publisher: BoD – Books on Demand

Published: 2013-05-22

Total Pages: 516

ISBN-13: 953511123X

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This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Oxidative Stress and Antioxidant Protection
Oxidative Stress and Antioxidant Protection

Author: Donald Armstrong

Publisher: John Wiley & Sons

Published: 2016-04-11

Total Pages: 610

ISBN-13: 1118832485

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Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.