Organometallics in Process Chemistry
Organometallics in Process Chemistry

Author: Ahmed F. Abdel-Magid

Publisher: Springer Science & Business Media

Published: 2004-06-15

Total Pages: 316

ISBN-13: 9783540016038

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The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.

Organometallics as Catalysts in the Fine Chemical Industry
Organometallics as Catalysts in the Fine Chemical Industry

Author: Matthias Beller

Publisher: Springer

Published: 2012-08-31

Total Pages: 165

ISBN-13: 3642328334

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Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoît Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.

Carbon Dioxide and Organometallics
Carbon Dioxide and Organometallics

Author: Xiao-Bing Lu

Publisher: Springer

Published: 2015-08-26

Total Pages: 313

ISBN-13: 3319220780

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The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal

Organometallic Chemistry in Industry
Organometallic Chemistry in Industry

Author: Thomas J. Colacot

Publisher: John Wiley & Sons

Published: 2020-05-26

Total Pages: 336

ISBN-13: 3527345175

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Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

Organometallic Fluorine Chemistry
Organometallic Fluorine Chemistry

Author: Thomas Braun

Publisher: Springer

Published: 2015-08-05

Total Pages: 247

ISBN-13: 3319220969

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The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics in pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.

Aqueous Organometallic Catalysis
Aqueous Organometallic Catalysis

Author: Ferenc Joo

Publisher: Springer Science & Business Media

Published: 2001-11-30

Total Pages: 307

ISBN-13: 1402001959

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Over the past 20 years aqueous organometallic catalysis has found applications in small- scale organic synthesis in the laboratory, as well as in the industrial production of chemicals with a combined output close to one million tons per year. Aqueous/organic two-phase reactions allow easy product-catalyst separation and full catalyst recovery which mean clear benefits not only in economic but also in environmental and green chemistry contexts. Instead of putting together a series of expert reviews of specialized fields, this book attempts to give a comprehensive yet comprehensible description of the various catalytic transformations in aqueous systems as seen by an author who has been working on aqueous organometallic catalysis since its origin. Emphasis is put on the discussion of differences between related non-aqueous and aqueous processes due to the presence of water. The book will be of interest to experts and students working in catalysis, inorganic chemistry or organic synthesis, and may serve as a basis for advanced courses.

Organometallic Mechanisms and Catalysis
Organometallic Mechanisms and Catalysis

Author: Jay Kochi

Publisher: Academic Press

Published: 1978

Total Pages: 656

ISBN-13:

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Organometallic Mechanisms and Catalysis: The Role of Reactive Intermediates in Organic Processes covers the mechanistic delineation of organometallic chemistry and catalysis. This book is organized into three parts encompassing 18 chapters. The first part describes first the oxidation-reduction process of organometals, followed by discussions on the catalytic reactions of peroxides, metal-catalyzed addition to olefins, and reduction of organic halides. This part also explores other reactions involving transition metal carbonyls and metal-catalyzed reactions of aromatic diazonium salts. The second part deals with some chemical aspects of organometals, such as their stability, thermochemistry, decomposition, hemolytic pathways, and the formation of carbon-carbon bonds. The third part examines the charge transfer processes and interactions of organometals with electron acceptors. This part further looks into the cleavage and insertion reactions of organometals with electrophiles, as well as the electrophilic and electron transfer mechanisms of organometals. Organic and inorganic chemists, teachers, and students will greatly benefit from this book.

Organometallics in Process Chemistry
Organometallics in Process Chemistry

Author: Thomas J. Colacot

Publisher: Springer Nature

Published: 2020-04-01

Total Pages: 334

ISBN-13: 3030279618

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This volume gives an overview of the applications of organometallic chemistry in process chemistry relevant to the current topics in synthetic chemistry. This volume starts with an introduction on the historical development of organometallics in process chemistry and is followed by chapters dealing with the last five years’ development in various organometallic reaction types such as the challenging cross coupling process, construction of 3.1.0 bicycles, pressure and transfer hydrogenations of historically challenging compounds such as esters, utilization of carbon dioxide for making organic compounds by flow process, drug synthesis and metal detection and scavenging in the finished APIs. A chapter by Colacot et.al., is also devoted to the process development and structural understanding of organometallic catalysts with particular emphasis to LnPd(0) catalysts. An academia – industry collaborated chapter on the use of water as a solvent for organometallic processes is included in this book.

Organometallics for Green Catalysis
Organometallics for Green Catalysis

Author: Pierre H. Dixneuf

Publisher: Springer

Published: 2019-02-25

Total Pages: 309

ISBN-13: 3030109550

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This volume presents the latest developments in the use of organometallic catalysis for the formation of bulk chemicals and the production of energy, via green processes including efficient utilization of waste feedstocks from industry. The chemistry of carbon dioxide relating to its hydrogenation into methanol –an eco-friendly energy storage strategy– and its uses as C1 synthon for the formation of important building-blocks for fine chemicals industry are covered. Catalytic hydrogenations of various functional groups and hydrogen transfer reactions including the use of first row metal catalysts are presented as well as the conversion of alcohols to carboxylates via hydrogen transfer with a zero-waste strategy using water. Transformation of renewable or bio-based raw materials is surveyed through alkene metathesis and C–O bond activations and functionalizations. A green aspect for selective formation of C-C, C-O and C-N bonds involves direct regioselective C–H bond activations and functionalizations. These transformations can now be promoted under mild reaction conditions due to the use photoredox catalyts. C–H bond oxidation using visible light leads mainly to the formation of C–O and C–N bonds, whereas cross-coupled C–C bonds can be formed through the radical additions on (hetero) arenes using photoredox assisted mechanism.