Asthma: Pathophysiology, Herbal and Modern Therapeutic Interventions

Asthma: Pathophysiology, Herbal and Modern Therapeutic Interventions

Author: Sheikh Rayees

Publisher: Springer Nature

Published: 2021-03-26

Total Pages: 71

ISBN-13: 3030702707

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Asthma is a chronic airway disease affecting over 300 million people worldwide with an expected increase of an additional 100 million by 2025. Past decade has observed a notable increase in asthma prevalence on both national and global levels with highest rates observed in western countries (about 30%). Over the past 40 years, a drastic increase in global prevalence, morbidity, mortality, and economic burden have been observed due to asthma especially in children. The rising numbers of hospital admissions for asthma, especially young children, reflect an increase in severe asthma, poverty and lack of proper disease management. Worldwide, approximately 180,000 deaths annually are caused due to this condition. The financial burden on a single asthma patient per year in different western countries ranges from US$300–1,300. Asthma is an intricate respiratory disorder with differences in its severity, natural history and hence treatment response. These differences in intensities of various presentations such as bronchial hyper-responsiveness, airway inflammation, mucus production, airflow obstruction make asthma a heterogeneous disease. The mainstay of current therapies for asthma includes inhaled corticosteroids, phosphodiesterase inhibitors, leukotriene modifiers and β2-adrenoceptor agonists. Some of the currently available drugs are efficient in one or more aspects. However the associated side effects or heterogeneity of the disease limit their usefulness and efficacy, thereby putting a demand on development of new drugs and therapies. On the other hand, asthma has also been treated/managed via herbal medications. These approaches have been described in Unani, Ayurvedic or Chinese system of medicine since antiquity. In fact, several anti-asthmatic drugs were developed from herbs commonly utilized in the non-Western system of medicine. This book focuses on the pathophysiology of asthma, its medication (both herbal and modern), limitations and their future prospects.


Severe Asthma

Severe Asthma

Author: Kian Fan Chung

Publisher: European Respiratory Society

Published: 2019-06-01

Total Pages: 365

ISBN-13: 1849841047

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Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.


Breathing Space

Breathing Space

Author: Gregg Mitman

Publisher: Yale University Press

Published: 2008-10-01

Total Pages: 330

ISBN-13: 0300138326

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Allergy is the sixth leading cause of chronic illness in the United States. More than fifty million Americans suffer from allergies, and they spend an estimated $18 billion coping with them. Yet despite advances in biomedicine and enormous investment in research over the past fifty years, the burden of allergic disease continues to grow. Why have we failed to reverse this trend? Breathing Space offers an intimate portrait of how allergic disease has shaped American culture, landscape, and life. Drawing on environmental, medical, and cultural history and the life stories of people, plants, and insects, Mitman traces how America’s changing environment from the late 1800s to the present day has led to the epidemic growth of allergic disease. We have seen a never-ending stream of solutions to combat allergies, from hay fever resorts, herbicides, and air-conditioned homes to numerous potions and pills. But, as Mitman shows, despite the quest for a magic bullet, none of the attempted solutions has succeeded. Until we address how our changing environment—physical, biological, social, and economic—has helped to create America’s allergic landscape, that hoped-for success will continue to elude us.


Difficult To Treat Asthma

Difficult To Treat Asthma

Author: Sandhya Khurana

Publisher: Springer Nature

Published: 2019-08-29

Total Pages: 339

ISBN-13: 3030208125

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This book provides a practical, stepwise, evidence-based approach to effective management of patients with difficult to treat asthma. The impact of asthma on morbidity and healthcare utilization increases exponentially with severity. Severe refractory asthma accounts for less than 5% of all asthma. Its prevalence, however, is often overestimated as there are several other confounding factors that make asthma ‘difficult to treat’. Many novel (albeit expensive) therapies are now available and providers caring for patients with severe asthma are charged with selecting the best evidence treatment. This calls for complex and nuanced decision-making. Whether people with asthma gain and maintain control over their condition depends not only on the availability of effective drugs, but also multiple patient and healthcare provider behaviors. Therefore, now more than ever, it has become increasingly important to differentiate “difficult” from “severe refractory” asthma to allow identification of patients most likely to benefit from these therapies. This volume delves into the current understanding of mechanisms and increasingly recognized heterogeneity of this complex disease. It discusses a structured approach to identification and optimization of factors contributing to poor asthma control, including nonadherence, comorbidities and occupational/environmental triggers. The book includes ‘state of the art’ reviews on recent advances in traditional and targeted asthma therapies, as well as a glimpse into what the future may hold. Highlights include a comprehensive guide to management of severe asthma in children and pregnancy, as well as practical considerations to management of asthma based on different clinical phenotypes. Each chapter is authored by leading experts in the field who share their own clinical approach. This is an ideal guide for clinical pulmonologists and allergist/immunologists, as well as primary care providers, physician extenders in specialty practice, physicians in pulmonary/allergy training, and even industry partners.


Childhood Asthma

Childhood Asthma

Author: Stanley J Szefler

Publisher: CRC Press

Published: 2005-09-26

Total Pages: 740

ISBN-13: 084935224X

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This reference collects the latest studies on the development, diagnosis, and treatment of childhood asthma and offers current perspectives on new technologies that will shape the management of pediatric asthma in the forthcoming decade-illustrating how advances in pulmonary function measurement, inflammatory markers, imaging, and pharmacogenetics


Natural Relief for Your Child's Asthma

Natural Relief for Your Child's Asthma

Author: M.D. Bock, Steven J.

Publisher: Harper Perennial

Published: 1999-04-01

Total Pages: 308

ISBN-13: 9780060952891

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A groundbreaking, practical, and holistic approach to treating children with chronic asthma From two physicians with fifteen years of experience in treating asthma comes the only book for children with asthma that supplements conventional approaches with effective and proven natural remedies. Parenting a child with asthma is often scary, unpredictable, frustrating, and expensive. Through controlling symptoms, decreasing attacks, and eventually reducing the need for prescription drugs, the Drs. Bock will help you and your child regain control of your lives. This book will show you how to: reduce attacks by dealing with the underlying causes reduce the need for conventional drugs, making them safer to use for emergencies help your child's body heal itself avoid permanent lung damage and encourage healthy new lung tissue to grow minimize emergency room visits, time lost from school, and time lost from work detoxify your environment, minimizing the effects of pollen, dust mites, and mold identify foods that can trigger attacks properly use nutritional supplements build a treatment and prevention program tailored to your child's needs This medically up-to-date, practical, and supportive book focuses on stopping asthma symptoms and attacks before they start. It is a must-have reference for any parent of a child with asthma.


Middleton's Allergy Essentials E-Book

Middleton's Allergy Essentials E-Book

Author: Robyn E. O'Hehir

Publisher: Elsevier Health Sciences

Published: 2015-12-09

Total Pages: 421

ISBN-13: 0323392733

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For decades, health care practitioners have relied on Middleton’s Allergy as their go-to reference for comprehensive information on allergic disorders. Now Middleton’s Allergy Essentials, by Drs. Robyn E. O'Hehir, Stephen T. Holgate, and Aziz Sheikh, offers a concise resource that’s both easily accessible and highly authoritative. Perfect for clinicians in primary and secondary care settings, this practical volume covers what is most useful in your daily practice, with a strong emphasis on disease diagnosis and management. A practical approach to evaluation, differential diagnosis, and treatment of allergic disorders, focused specifically on what the non-specialist needs to know for everyday practice. Each chapter begins with a handy summary of key concepts to help you quickly identify important information. Coverage of today’s hot topics includes asthma, drug allergies, food allergies and gastrointestinal disorders, anaphylaxis, atopic dermatitis, and allergic contact dermatitis. Concise sections on mechanisms are included where relevant, keeping you up to date with this rapidly evolving field. Authored by the same internationally recognized experts that produce Middleton’s Allergy, the definitive text in the field. Ideal for physicians, residents, general and family practitioners, nurse practitioners, primary care doctors, hospitalists, general internists – anyone who is called upon to make effective diagnostic and treatment decisions regarding allergic disorders.


Asthma and COPD

Asthma and COPD

Author: Peter J. Barnes

Publisher: Elsevier

Published: 2009-03-19

Total Pages: 897

ISBN-13: 0080920608

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The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations