OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

Author: OECD

Publisher: OECD Publishing

Published: 2021-06-17

Total Pages: 28

ISBN-13: 9264242848

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This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 404: Acute Dermal Irritation/Corrosion
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 404: Acute Dermal Irritation/Corrosion

Author: OECD

Publisher: OECD Publishing

Published: 2015-07-28

Total Pages: 8

ISBN-13: 9264242678

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This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation

Author: OECD

Publisher: OECD Publishing

Published: 2018-06-27

Total Pages: 67

ISBN-13: 9264229825

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This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion

Author: OECD

Publisher: OECD Publishing

Published: 2015-07-28

Total Pages: 13

ISBN-13: 9264242791

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This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method

Author: OECD

Publisher: OECD Publishing

Published: 2019-06-18

Total Pages: 29

ISBN-13: 9264264612

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The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.