OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9)
OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9)

Author: OECD

Publisher: OECD Publishing

Published: 2018-06-27

Total Pages: 36

ISBN-13: 9264303235

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The Test Guideline (TG) describes the use of liver S9 sub-cellular fraction (RT-S9) of rainbow trout (Oncorhynchus mykiss) as a metabolising system to determine the clearance (CL, IN VITRO, INT ) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the ...

OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 314: Simulation Tests to Assess the Biodegradability of Chemicals Discharged in Wastewater
OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 314: Simulation Tests to Assess the Biodegradability of Chemicals Discharged in Wastewater

Author: OECD

Publisher: OECD Publishing

Published: 2008-10-16

Total Pages: 51

ISBN-13: 9264067493

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This Test Guideline describes a method to assess the extent and kinetics of primary and ultimate biodegradation of organic chemicals whose route of entry into the environment begins with their discharge to wastewater. It consists of five simulation ...

OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319A: Determination of in vitro intrinsic clearance using cryopreserved rainbow trout hepatocytes (RT-HEP)
OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319A: Determination of in vitro intrinsic clearance using cryopreserved rainbow trout hepatocytes (RT-HEP)

Author: OECD

Publisher: OECD Publishing

Published: 2018-06-27

Total Pages: 41

ISBN-13: 9264303219

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The Test Guideline (TG) describes the use of cryopreserved rainbow trout (Oncorhynchus mykiss) hepatocytes (RT-HEP) as a metabolising system to determine the clearance (CL, IN VITRO, INT) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the RT-HEP ...

OECD Guidelines for the Testing of Chemicals / Section 3: Degradation and Accumulation Revised Introduction to the OECD Guidelines for Testing of Chemicals, Section 3
OECD Guidelines for the Testing of Chemicals / Section 3: Degradation and Accumulation Revised Introduction to the OECD Guidelines for Testing of Chemicals, Section 3

Author: OECD

Publisher: OECD Publishing

Published: 2006-09-11

Total Pages: 17

ISBN-13: 9264030212

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The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers environmental fate and behaviour. In 2017, the section 3 "Degradation and Accumulation" was renamed to " Environmental fate and behaviour" to take into account Test Guidelines measuring endpoints such as dispersion, aggregation.

OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 250: EASZY assay - Detection of Endocrine Active Substances, acting through estrogen receptors, using transgenic tg(cyp19a1b:GFP) Zebrafish embrYos
OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 250: EASZY assay - Detection of Endocrine Active Substances, acting through estrogen receptors, using transgenic tg(cyp19a1b:GFP) Zebrafish embrYos

Author: OECD

Publisher: OECD Publishing

Published: 2021-06-17

Total Pages: 45

ISBN-13: 9264886109

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The EASZY assay is a mechanism-based in vivo screening assay designed to detect endocrine active chemicals acting as agonist through estrogen receptors (ERs), by inducing the expression of the green fluorescent protein (GFP) driven by the cyp19a1b promoter. The EASZY assay allows for the detection of estrogenic activity of chemicals on transgenic tg(cyp19a1b:GFP) Zebrafish embryos exposed for 96 hours during the embryonic stages of development.

OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 251: Rapid Androgen Disruption Activity Reporter (RADAR) assay
OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 251: Rapid Androgen Disruption Activity Reporter (RADAR) assay

Author: OECD

Publisher: OECD Publishing

Published: 2022-06-30

Total Pages: 44

ISBN-13: 9264910557

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The Rapid Androgen Disruption Activity Reporter (RADAR) Test Guideline describes an aquatic assay that utilizes transgenic Oryzias latipes (O. latipes, Japanese medaka) eleutheroembryos at day post hatch zero, in a multi-well format to detect chemicals active on the androgen axis.

OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 242: Potamopyrgus antipodarum Reproduction Test
OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 242: Potamopyrgus antipodarum Reproduction Test

Author: OECD

Publisher: OECD Publishing

Published: 2016-07-29

Total Pages: 23

ISBN-13: 9264264310

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The Potamopyrgus antopodarumon reproduction test is designed to assess potential effects of prolonged exposure to chemicals on reproduction and survival of parthenogenetic lineages of the freshwater mudsnail Potamopyrgus antipodarum. Adult female P. antipodarum are exposed to a concentration ...