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Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
Published: 1981
Total Pages:
ISBN-13: 9789264122215
DOWNLOAD EBOOKAuthor: OECD
Publisher: OECD Publishing
Published: 2010-07-23
Total Pages: 25
ISBN-13: 9264090894
DOWNLOAD EBOOKThis Test Guideline describes procedures designed to estimate the acute oral toxicity of substances to birds, and it provides three testing options: (1) limit dose test, (2) LD50-slope test, and (3) LD50-only test. The LD50-slope and LD50-only ...
Author: OECD
Publisher: OECD Publishing
Published: 2002-02-08
Total Pages: 14
ISBN-13: 9264071008
DOWNLOAD EBOOKThis is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
Author: OECD
Publisher: OECD Publishing
Published: 2002-02-08
Total Pages: 14
ISBN-13: 926407094X
DOWNLOAD EBOOKA principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Author: OECD
Publisher: OECD Publishing
Published: 2018-06-27
Total Pages: 18
ISBN-13: 9264071202
DOWNLOAD EBOOKThe objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...
Author: Hajime Kojima
Publisher: Springer
Published: 2018-12-27
Total Pages: 136
ISBN-13: 9811324476
DOWNLOAD EBOOKThis open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
Author: OECD
Publisher: OECD Publishing
Published: 2009-09-08
Total Pages: 20
ISBN-13: 9264070605
DOWNLOAD EBOOKThis method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author: OECD
Publisher: OECD Publishing
Published: 2014-09-26
Total Pages: 25
ISBN-13: 9264224173
DOWNLOAD EBOOKThe in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Author: OECD
Publisher: OECD Publishing
Published: 1995-07-27
Total Pages: 10
ISBN-13: 9264070966
DOWNLOAD EBOOKThe test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...
Author: OECD
Publisher: OECD Publishing
Published: 2016-07-29
Total Pages: 21
ISBN-13: 9264264760
DOWNLOAD EBOOKThe mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
