Research on the nuclear matrix has grown enormously since Bereney and Coffey first reported its isolation and initial characterization in 1974. Since then, more than 1000 papers have been published on the subject by numerous workers around the world. This is the first book devoted to reviewing the major developments in this growing field. Key Features * The chapters cover a variety of topics, including: * Isolation of the nuclear matrix * Nuclear structure morphology in situ * Structural domains of the nuclear matrix and its components * Biochemistry and molecular biology of the matrix proteins and associated DNA and RNA * Functional properties associated with the nuclear matrix * DNA replication * Transcription * RNA splicing * Transcription regulation * Intranuclear and nucleocytoplasmic transport and targeting * Cell cycle regulation
Commencing with a self-contained overview of atomic collision theory, this monograph presents recent developments of R-matrix theory and its applications to a wide-range of atomic molecular and optical processes. These developments include the electron and photon collisions with atoms, ions and molecules which are required in the analysis of laboratory and astrophysical plasmas, multiphoton processes required in the analysis of superintense laser interactions with atoms and molecules and positron collisions with atoms and molecules required in antimatter studies of scientific and technologial importance. Basic mathematical results and general and widely used R-matrix computer programs are summarized in the appendices.
Beginning with the development of the atomic bomb during World War II, the United States continued to build nuclear weapons throughout the Cold War. Thousands of people mined and milled uranium, conducted research on nuclear warfare, or worked in nuclear munitions factories around the country from the 1940s through the 1980s. Such work continues today, albeit to a smaller extent. The Department of Energy (DOE) is now responsible for overseeing those sites and facilities, many of which were, and continue to be, run by government contractors. The materials used at those sites were varied and ranged from the benign to the toxic and highly radioactive. Workers at DOE facilities often did not know the identity of the materials with which they worked and often were unaware of health risks related to their use. In many instances, the work was considered top secret, and employees were cautioned not to reveal any work-related information to family or others. Workers could be exposed to both radioactive and nonradioactive toxic substances for weeks or even years. Consequently, some of the workers have developed health problems and continue to have concerns about potential health effects of their exposures to occupational hazards during their employment in the nuclear weapons industry. In response to the concerns expressed by workers and their representatives, DOL asked the Institute of Medicine (IOM) to review the SEM database and its use of a particular database, Haz-Map, as the source of its toxic substance-occupational disease links. Accordingly, this IOM consensus report reflects careful consideration of its charge by the committee, and describes the strengths and shortcomings of both. To complete its task, IOM formed an ad hoc committee of experts in occupational medicine, toxicology, epidemiology, industrial hygiene, public health, and biostatistics to conduct an 18-month study to review the scientific rigor of the SEM database. The committee held two public meetings at which it heard from DOL Division of Energy Employee Occupational Illness Compensation (DEEOIC) representatives, the DOL contractor that developed the SEM database, the developer of the Haz-Map database, DOE worker advocacy groups, and several individual workers. The committee also submitted written questions to DOL to seek clarification of specific issues and received written responses from DEEOIC. The committee's report considers both the strengths and weaknesses of the SEM and the Haz-Map databases, recognizing that the latter was developed first and for a different purpose. The committee then discusses its findings and recommends improvements that could be made in both databases with a focus on enhancing the usability of SEM for both DOL claims examiners and for former DOE workers and their representatives. Review of the Department of Labor's Site Exposure Matrix Database summarizes the committee's findings.
This book is a comprehensive source of information on various aspects of ceramic matrix composites (CMC). It covers ceramic and carbon fibers; the fiber-matrix interface; processing, properties and industrial applications of various CMC systems; architecture, mechanical behavior at room and elevated temperatures, environmental effects and protective coatings, foreign object damage, modeling, life prediction, integration and joining. Each chapter in the book is written by specialists and internationally renowned researchers in the field. This book will provide state-of-the-art information on different aspects of CMCs. The book will be directed to researchers working in industry, academia, and national laboratories with interest and professional competence on CMCs. The book will also be useful to senior year and graduate students pursuing degrees in ceramic science and engineering, materials science and engineering, aeronautical, mechanical, and civil or aerospace engineering. Presents recent advances, new approaches and discusses new issues in the field, such as foreign object damage, life predictions, multiscale modeling based on probabilistic approaches, etc. Caters to the increasing interest in the application of ceramic matrix composites (CMC) materials in areas as diverse as aerospace, transport, energy, nuclear, and environment. CMCs are considered ans enabling technology for advanced aeropropulsion, space propulsion, space power, aerospace vehicles, space structures, as well as nuclear and chemical industries. Offers detailed descriptions of ceramic and carbon fibers; fiber-matrix interface; processing, properties and industrial applications of various CMC systems; architecture, mechanical behavior at room and elevated temperatures, environmental effects and protective coatings, foreign object damage, modeling, life prediction, integration/joining.
THE NEW YORK TIMES BESTSELLER SHORTLISTED FOR THE NATIONAL BOOK AWARDS AN OBAMA'S BOOK OF THE YEAR 'Gorgeous, sensual, addictive' SARA COLLINS 'Brightly lit' NAOMI ALDERMAN Born from a long line of female warriors and crusaders, yet too coarse for courtly life, Marie de France is cast from the royal court and sent to Angleterre to take up her new duty as the prioress of an impoverished abbey. Lauren Groff's modern masterpiece is about the establishment of a female utopia. 'A propulsive, captivating read' BRIT BENNETT 'Fascinating, beguiling, vivid' MARIAN KEYES 'A dazzlingly clever tale' THE TIMES 'A thrillingly vivid, adventurous story about women and power that will blow readers' minds. Left me gasping' EMMA DONOGHUE
The histones are now a very well established part of Biochemistry. The interpretation of all that is known about them, however, is already too great a burden for a single author to undertake. Indeed, a survey of the indexed literature shows that the number of publications on the histones has approximately doubled in every three years for the past 15 years, and is now several hundred a year. It is time then to bring together in one publication the major topics embraced by this great research effort. This book therefore endeavours to give, in six chapters, a broad and searching account of the biochemistry and biophysics of these interesting proteins and their complexes with nucleic acids, the nucleohistones. Each chapter is written by different authors who are all active in this research and who have had many years experience with these proteins and their complexes. Chapters 1, 2, part of 3, and all of Chapters 5 and 6, cover the occurrence, preparation, characterization, sequence structure, bio physical properties and finally, the biosynthesis and functions of the histones. The other part of Chapter 3, the whole of Chapter 4 and to a less extent some other chapters, all discuss the properties and structure of the nucleohistones. The study of these complexes is undoubtedly of great importance in bridging the gaps in our knowledge of template activity and differentiation as well as of chromosomal structure and mechanics.
The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.
From Nucleons to Nucleus deals with single-particle and collective features of spherical nuclei. Each nuclear model is introduced and derived in detail. The formalism is then applied to light and medium-heavy nuclei in worked-out examples, and finally the acquired skills are strengthened by a wide selection of exercises, many relating the models to experimental data. Nuclear properties are discussed using particles, holes and quasi-particles. From Nucleons to Nucleus is based on lectures on nuclear physics given by the author, and serves well as a textbook for advanced students. Researchers too will appreciate it as a well-balanced reference to theoretical nuclear physics.
