Methylene Blue Trihydrate (MBT) has a variety of biomedical and biologically therapeutic applications. MBT was nominated by the Nat. Cancer Inst. for carcinogenecity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of MBT, as well as the inadequate animal data on this compound. Male and female F344/N rats and B6C3F1 mice were administered MBT in 0.5% aqueous methylcellulose by gavage for 1 month, 3 months, or 2 years. Genetic toxicology studies were conducted using ¿Salmonella typhimurium,¿ ¿Escherichia coli,¿ cultured Chinese hamster ovary cells, mouse bone marrow cells, and mouse peripheral blood erythrocytes. Illustrations.
Praise for the Second Edition “This book should be an essential part of the personal library of every practicing statistician.”—Technometrics Thoroughly revised and updated, the new edition of Nonparametric Statistical Methods includes additional modern topics and procedures, more practical data sets, and new problems from real-life situations. The book continues to emphasize the importance of nonparametric methods as a significant branch of modern statistics and equips readers with the conceptual and technical skills necessary to select and apply the appropriate procedures for any given situation. Written by leading statisticians, Nonparametric Statistical Methods, Third Edition provides readers with crucial nonparametric techniques in a variety of settings, emphasizing the assumptions underlying the methods. The book provides an extensive array of examples that clearly illustrate how to use nonparametric approaches for handling one- or two-sample location and dispersion problems, dichotomous data, and one-way and two-way layout problems. In addition, the Third Edition features: The use of the freely available R software to aid in computation and simulation, including many new R programs written explicitly for this new edition New chapters that address density estimation, wavelets, smoothing, ranked set sampling, and Bayesian nonparametrics Problems that illustrate examples from agricultural science, astronomy, biology, criminology, education, engineering, environmental science, geology, home economics, medicine, oceanography, physics, psychology, sociology, and space science Nonparametric Statistical Methods, Third Edition is an excellent reference for applied statisticians and practitioners who seek a review of nonparametric methods and their relevant applications. The book is also an ideal textbook for upper-undergraduate and first-year graduate courses in applied nonparametric statistics.
This book focuses on the toxicity of various organic and inorganic pollutants, their eco-toxicological effects and eco-friendly approaches for remediation of environmental pollutants. Extensive focus has been relied on the recent advances in ecofriendly approaches such as bioremediation and phytoremediation technologies, including the use of various group of microbes for remediation of environmental pollutants, etc. Researchers working in the field of bioremediation, phytoremediation, waste management and related fields will find this compilation most useful for further study to learn about the subject matter.
Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzyme
This reference work analyzes and assesses global environmental management techniques for environmental materials with a focus on their performance and economic benefits, proposing eco-friendly solutions and designating policies that will sustain the environment for future generations. It addresses management of environmental materials as not only a complex anthropogenic problem, but also as an expensive problem that needs to be managed sustainably. Simultaneously, it considers the environmental and economic benefits involved in the high levels of investment and operation costs required to develop effective materials collection and management systems in modern society.
Chromium is a metal that exists in a variety of valence states, depending on surrounding conditions and what other atoms it is bound to. The most stable forms are metallic chromium, trivalent chromium (chromium III), and hexavalent chromium (chromium VI). Chromium VI has been shown to cause cancer when inhaled in the air. Because compounds containing chromium VI occur as contaminants in drinking water, scientists studied the effects of sodium dichromate dihydrate (SDD) in drinking water on rats and mice to identify potential toxic or cancer-related hazards. Results showed that rats exposed to SDD had carcinomas of the mouth, but none occurred in the control rats. Mice receiving SDD had greatly increased rates of cancer of the small intestine. Illus.
