NIH State-of-the-science Conference Statement on Preventing Alzheimer's Disease and Cognitive Decline
Author: National Institutes of Health (U.S.)
Publisher:
Published: 2010
Total Pages: 30
ISBN-13:
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Preventing Alzheimer's Disease and Cognitive Decline
Author: Ahrq Government Agency
Publisher: CreateSpace
Published: 2014-05-15
Total Pages: 728
ISBN-13: 9781499557084
DOWNLOAD EBOOKThis book is a B&W copy of the government agency publication.Dementia is a loss of cognitive abilities in multiple domains that results in impairment in normal activities of daily living and loss of independence. Alzheimer's disease (AD) is the most common cause of dementia, responsible for 60 to 80 percent of all dementia. AD causes severe suffering for patients, including progressive functional impairment, loss of independence, emotional distress, and behavioral symptoms. Families and caregivers often experience emotional and financial stress. The major risk factor for AD is age, with the prevalence doubling every 5 years after the age of 65. Most estimates of the prevalence of AD in the United States are about 2.3 million for individuals over age 70, but some estimates are as high as 5.3 million individuals over the age of 65. The number of individuals with mild cognitive impairment exceeds the number with AD. These individuals have mild impairment in cognition or daily functions that does not meet the threshold for a diagnosis of dementia, but they are at increased risk for development of AD, which makes them a prime target for intervention protocols. Studies of selected risk or protective factors for cognitive decline and AD have been published, but it is not clear whether the results of these previous studies are of sufficient strength to warrant specific recommendations for behavioral, lifestyle, or pharmaceutical interventions/modifications targeted to these endpoints. As background for an upcoming State-of-the-Science Conference in April 2010, the National Institutes of Health (NIH) Office of Medical Applications of Research (OMAR) commissioned this evidence report on “Preventing Alzheimer's Disease and Cognitive Decline” through the Agency for Healthcare Research and Quality (AHRQ). The aim is to summarize the available literature, frame the discussion regarding potential risk factors, and highlight the limitations of the evidence base. We synthesized the existing literature on the following key questions: Key Question 1: What factors are associated with the reduction of risk of Alzheimer's disease? Key Question 2: What factors are associated with the reduction of risk of cognitive decline in older adults? Key Question 3: What are the therapeutic and adverse effects of interventions to delay the onset of Alzheimer's disease? Are there differences in outcomes among identifiable subgroups? Key Question 4: What are the therapeutic and adverse effects of interventions to improve or maintain cognitive ability or function? Are there differences in outcomes among identifiable subgroups? Key Question 5: What are the relationships between the factors that affect Alzheimer's disease and the factors that affect cognitive decline? Key Question 6: If recommendations for interventions cannot be made currently, what studies need to be done that could provide the quality and strength of evidence necessary to make such recommendations to individuals?
Nutrition and Prevention of Alzheimer's Disease
Author: Claudia Perez-Cruz
Publisher: Frontiers Media SA
Published: 2015-12-18
Total Pages: 78
ISBN-13: 2889197190
DOWNLOAD EBOOKAltered metabolism is known to be associated with a higher incidence of Alzheimer´s disease (AD). Diabetes type 2, obesity, and metabolic syndrome are considered risk factors for the development of dementias, including AD. These metabolic diseases may have a genetic predisposition, but most of them are caused by environmental factors and life-style. Most research has focused on the effect of a high-fat diet (HFD) and sweetened beverages that induce obesity. Importantly, a HFD can also trigger oxidative stress, neuro-inflammation and cognitive decline. Less is known, however, about beneficial effects of diet on cognition, such as slowing the progression or preventing AD by ingesting whole fruits, vegetables, fish and oil. It is important to highlight the difference between vitamin/mineral supplements and whole food, as it appears that the former are clinically ineffective, while multiple ingredients in the latter act synergistically to improve cognition. As AD is a disease of slow progression, therapies should start several decades before clinical symptoms can be observed; one strategy can be the ingestion of healthy food in those subjects with one or more risk factors (genetic, environmental, life-style) already in their 40s, just when some brain metabolic disturbances start to develop. This dietary therapy can overcome the increased reactive oxygen species, protein deposition and synaptic failure, characteristic of AD. This research topic will cover a range of research articles, case studies, opinion and mini-reviews, all focused on describing the damaging effects of an industrial diet on cognition as well as on highlighting the beneficial effects of a healthy diet to prevent AD. We believe that we still have time to fight against the negative impact of our industrialized cultures, and adopt better eating habits, increase exercise and slow down our life style to prevent increasing dementia in the aging population. Also, all these topics has been a product of intensives investigations, with a great life hope, and we hope you all enjoy reading this e-book.
Preventing Alzheimer's Disease
Author: Yoram Barak
Publisher: Nova Science Publishers
Published: 2014-02-03
Total Pages: 0
ISBN-13: 9781628087178
DOWNLOAD EBOOKThe prevention of dementia, and particularly of Alzheimer's disease, is a major challenge for researchers and clinicians. In this book, the mixture of evidence, observations and hypotheses in the current literature is categorized into avenues for possible preventive interventions, as suggested by the NIH State-of-the-Science Conference. The main categories are: antihypertensive medications; nutrition; cognitive engagement; volunteering and physical activity. There is, as yet, no conclusive evidence, but each category may hold promise for the prevention of dementia. The robust findings are as follows: cognitive engagement and regular physical activity may reduce the risk of Alzheimer's disease; the Mediterranean diet and consumption of omega-3 fatty acids deserves further elucidation; and the meticulous management of risk factors, and especially hypertension, is the infrastructure of Alzheimer's disease prevention. Combating loneliness and volunteering both contribute to reducing the risk of dementia.
Mental Health and Illness of the Elderly
Author: Helen Chiu
Publisher: Springer
Published: 2017-08-22
Total Pages: 611
ISBN-13: 9789811024122
DOWNLOAD EBOOKThis book consolidates current knowledge in the field and discusses psychiatric disorders among the elderly, while bridging the gap between clinical practice and the socio-cultural contexts. The book is particularly important in the face of rapidly changing conditions globally and challenges such as migration, war and violence, diminishing physical health due to ageing and their impact on the mental health of elderly. Longevity is a great gift of medical sciences and modern health care and since the benefit of longevity comes with specific mental health issues of the elderly, this book responds to the heightened need to understand and address the mental health challenges of the elderly.
Families Caring for an Aging America
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Published: 2016-11-08
Total Pages: 367
ISBN-13: 0309448093
DOWNLOAD EBOOKFamily caregiving affects millions of Americans every day, in all walks of life. At least 17.7 million individuals in the United States are caregivers of an older adult with a health or functional limitation. The nation's family caregivers provide the lion's share of long-term care for our older adult population. They are also central to older adults' access to and receipt of health care and community-based social services. Yet the need to recognize and support caregivers is among the least appreciated challenges facing the aging U.S. population. Families Caring for an Aging America examines the prevalence and nature of family caregiving of older adults and the available evidence on the effectiveness of programs, supports, and other interventions designed to support family caregivers. This report also assesses and recommends policies to address the needs of family caregivers and to minimize the barriers that they encounter in trying to meet the needs of older adults.
New Developments in Dementia Prevention Research
Author: Kate Irving
Publisher: Routledge
Published: 2018-11-02
Total Pages: 213
ISBN-13: 135112269X
DOWNLOAD EBOOKNew Developments in Dementia Prevention Research addresses a dearth of knowledge about dementia prevention and shows the importance of considering the broader social impact of certain risk factors, including the role we each play in our own cognitive health throughout the lifespan. The book draws on primary and secondary research in order to investigate the relationship between modifiable factors, including vascular and psychosocial risks, that may affect the incidence of dementia. Bringing together world-leading expertise from applied science, medicine, psychology, health promotion, epidemiology, health economics, social policy and primary care, the book compares and contrasts scientific and service developments across a range of settings. Each chapter presents these themes in a way that will ensure best practice and further research in the field of dementia prevention is disseminated successfully throughout the world. Perhaps most importantly, chapters also question what type of social responsibility we are prepared to embrace in order to address the challenges inherent in dementia prevalence. New Developments in Dementia Prevention Research includes contributions from leading authorities in brain health and dementia prevention and provides an essential contribution to the discourse on dementia prevention. It will be of great interest to academics, researchers and postgraduate students engaged in the study of the psychological and social aspects of aging and dementia.
Diet and Cognitive Decline
Author: Francesco Panza
Publisher: Nova Publishers
Published: 2004
Total Pages: 188
ISBN-13: 9781594541216
DOWNLOAD EBOOKThe progressive ageing of the general population and the consequent increase of the number of old people has made the typical medical problems of aged people more frequently observed, and particularly the problems related to the ageing brain. This new book is an updated overview of relevant aspects of cognitive decline associated with ageing. Within the wide landscape of brain ageing the authors reconsider the role of the main predisposing factors and risk factors on the development of various form of mental decline, from mild cognitive impairment to dementia. The strength of this book is the large, updated overview of the most recent data of scientific literature regarding the role of genetic, metabolic and environmental factors on the predisposition and onset of cognitive decline. Particular attention is paid to the dietary micro- and macronutrients and to their possible role in the pathogenesis of the various form of dementigen disorders.
Preventing Cognitive Decline and Dementia
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Published: 2017-10-05
Total Pages: 181
ISBN-13: 0309459591
DOWNLOAD EBOOKSocieties around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or delay these conditions has been limited at best, despite the many claims of success made in popular media and advertising. Today, however, a growing body of prevention research is emerging. Preventing Cognitive Decline and Dementia: A Way Forward assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. This report provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging.
Outlive
Author: Peter Attia, MD
Publisher: Harmony
Published: 2023-03-28
Total Pages: 425
ISBN-13: 0593236602
DOWNLOAD EBOOK#1 NEW YORK TIMES BESTSELLER • OVER ONE MILLION COPIES SOLD • A groundbreaking manifesto on living better and longer that challenges the conventional medical thinking on aging and reveals a new approach to preventing chronic disease and extending long-term health, from a visionary physician and leading longevity expert “One of the most important books you’ll ever read.”—Steven D. Levitt, New York Times bestselling author of Freakonomics AN ECONOMIST AND BLOOMBERG BEST BOOK OF THE YEAR Wouldn’t you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health. For all its successes, mainstream medicine has failed to make much progress against the diseases of aging that kill most people: heart disease, cancer, Alzheimer’s disease, and type 2 diabetes. Too often, it intervenes with treatments too late to help, prolonging lifespan at the expense of healthspan, or quality of life. Dr. Attia believes we must replace this outdated framework with a personalized, proactive strategy for longevity, one where we take action now, rather than waiting. This is not “biohacking,” it’s science: a well-founded strategic and tactical approach to extending lifespan while also improving our physical, cognitive, and emotional health. Dr. Attia’s aim is less to tell you what to do and more to help you learn how to think about long-term health, in order to create the best plan for you as an individual. In Outlive, readers will discover: • Why the cholesterol test at your annual physical doesn’t tell you enough about your actual risk of dying from a heart attack. • That you may already suffer from an extremely common yet underdiagnosed liver condition that could be a precursor to the chronic diseases of aging. • Why exercise is the most potent pro-longevity “drug”—and how to begin training for the “Centenarian Decathlon.” • Why you should forget about diets, and focus instead on nutritional biochemistry, using technology and data to personalize your eating pattern. • Why striving for physical health and longevity, but ignoring emotional health, could be the ultimate curse of all. Aging and longevity are far more malleable than we think; our fate is not set in stone. With the right roadmap, you can plot a different path for your life, one that lets you outlive your genes to make each decade better than the one before.
