New Tools for the Schistosomiasis Elimination Toolbox: Barriers and Opportunities for the Development of a Topical Cercarial Anti-Penetrant
New Tools for the Schistosomiasis Elimination Toolbox: Barriers and Opportunities for the Development of a Topical Cercarial Anti-Penetrant

Author: Philip W. Downs

Publisher: RTI Press

Published: 2017-03-06

Total Pages: 18

ISBN-13:

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Schistosomiasis is a neglected tropical disease (NTD) affecting about 260 million people worldwide. Elimination of schistosomiasis remains a challenge because of high reinfection rates and limitations of current treatment guidelines and disease control interventions. Despite over 70 years of research on schistosome cercariae anti-penetrants, a personal protective product (PPP) remains elusive for the prevention of schistosomiasis. In this paper we explore perceptions of topical PPPs to identify potential opportunities and barriers in the development, promotion, and use as a tool to control and prevent schistosomiasis. Results from key informant interviews suggest that despite recognized benefits of a cercarial anti-penetrant, translation of research into a practical PPP for endemic areas is hindered by two critical issues: (1) minimal available evidence to demonstrate effective and practical use of topically applied products in community-based settings and (2) limitations of current business models to sustain product availability among high-risk groups in low-income settings. Additionally, introduction of a PPP would require an intensive behavioral change communication strategy to reinforce and enable routine use of the product. The potential additive impact of a PPP on reducing point of source infections, in combination with a comprehensive elimination strategy that includes preventive drug treatment, snail control, and improved water and sanitation, may still present an effective strategy to reduce moderate to high intensity of infection among high-risk groups, but requires additional translational research and business model development.

New Tools for the Schistosomiasis Elimination Toolbox
New Tools for the Schistosomiasis Elimination Toolbox

Author: Philip W. Downs

Publisher:

Published: 2017

Total Pages: 13

ISBN-13:

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Schistosomiasis is a neglected tropical disease (NTD) affecting about 260 million people worldwide. Elimination of schistosomiasis remains a challenge because of high reinfection rates and limitations of current treatment guidelines and disease control interventions. Despite over 70 years of research on Schistosome cercariae anti-penetrants, a personal protective product (PPP) remains elusive for the prevention of schistosomiasis. In this paper we explore perceptions of topical PPPs to identify potential opportunities and barriers in the development, promotion, and use as a tool to control and prevent schistosomiasis. Results from key informant interviews suggest that despite recognized benefits of a cercarial anti-penetrant, translation of research into a practical PPP for endemic areas is hindered by two critical issues: (1) minimal available evidence to demonstrate effective and practical use of topically applied products in community-based settings and (2) limitations of current business models to sustain product availability among high-risk groups in low-income settings. Additionally, introduction of a PPP would require an intensive behavioral change communication strategy to reinforce and enable routine use of the product. The potential additive impact of a PPP on reducing point of source infections, in combination with a comprehensive elimination strategy that includes preventive drug treatment, snail control, and improved water and sanitation, may still present an effective strategy to reduce moderate to high intensity of infection among high-risk groups, but requires additional translational research and business model development.

District Laboratory Practice in Tropical Countries, Part 2
District Laboratory Practice in Tropical Countries, Part 2

Author: Monica Cheesbrough

Publisher: Cambridge University Press

Published: 2006-03-02

Total Pages: 464

ISBN-13: 113944929X

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This new edition includes an update on HIV disease/AIDS, recently developed HIV rapid tests to diagnose HIV infection and screen donor blood, and current information on antiretroviral drugs and the laboratory monitoring of antiretroviral therapy. Information on the epidemiology and laboratory investigation of other pathogens has also been brought up to date. Several new, rapid, simple to perform immunochromatographic tests to assist in the diagnosis of infectious diseases are described, including those for brucellosis, cholera, dengue, leptospirosis, syphilis and hepatitis. Recently developed lgM antibody tests to investigate typhoid fever are also described. The new classification of salmonellae has been introduced. Details of manufacturers and suppliers now include website information and e-mail addresses. The haematology and blood transfusion chapters have been updated, including a review of haemoglobin measurement methods in consideration of the high prevalence of anaemia in developing countries.

District Laboratory Practice in Tropical Countries, Part 1
District Laboratory Practice in Tropical Countries, Part 1

Author: Monica Cheesbrough

Publisher: Cambridge University Press

Published: 2005-09-08

Total Pages: 470

ISBN-13: 9780521676304

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This new edition includes an update on HIV disease/AIDS, recently developed HIV rapid tests to diagnose HIV infection and screen donor blood, and current information on antiretroviral drugs and the laboratory monitoring of antiretroviral therapy. Information on the epidemiology and laboratory investigation of other pathogens has also been brought up to date. Several new, rapid, simple to perform immunochromatographic tests to assist in the diagnosis of infectious diseases are described, including those for brucellosis, cholera, dengue, leptospirosis, syphilis and hepatitis. Recently developed IgM antibody tests to investigate typhoid fever are also described. The new classification of salmonellae has been introduced. Details of manufacturers and suppliers now include website information and e-mail addresses. The haematology and blood transfusion chapters have been updated, including a review of haemoglobin measurement methods in consideration of the high prevalence of anaemia in developing countries. "The volume is packed with much valuable information, which is presented in a format that is readily readable. There are ample clear illustrations, tables and photographs to render the various information easy to digest. The authors have succeeded in producing a work that will fulfil an important need for developing countries. I highly recommend this book, with its Part I counterpart, to anyone with an interest in the practice of laboratory medicine." Pathology "...District Laboratory Practice in Tropical Countries sets the gold standard, and is an essential read and reference for anyone engaged in clinical laboratory practice in the tropics." Tropical Doctor Book jacket.

Parasitology
Parasitology

Author: Eric Loker

Publisher: Garland Science

Published: 2015-03-02

Total Pages: 577

ISBN-13: 1317407725

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Parasitology: A Conceptual Approach focuses on the conceptual basis of parasitology, with the goal of providing students with an enriched view of parasites and their biology. Concentrating on concepts will enable readers to gain a broader perspective that will increase their ability to think critically about all kinds of parasitic associations. The interfaces between the study of parasitism and prominent biological disciplines such as biodiversity, immunology, ecology, evolution, conservation biology, and disease control are highlighted. Studying individual parasites is an essential part of parasitology so Parasitology: A Conceptual Approach contains an appendix which provides a concise overview of the biology of important human and veterinary parasites. End-of-chapter questions are provided, as is an instructor manual.

Microbes
Microbes

Author: Prakash S. Bisen

Publisher: John Wiley & Sons

Published: 2012-06-22

Total Pages: 731

ISBN-13: 1118311892

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An accessible introduction to the world of microbes—from basic microbe biology through industrial applications Microbes affect our lives in a variety of ways—playing an important role in our health, food, agriculture, and environment. While some microbes are beneficial, others are pathogenic or opportunistic. Microbes: Concepts and Applications describes basic microbe biology and identification and shows not only how they operate in the subfields of medicine, biotechnology, environmental science, bioengineering, agriculture, and food science, but how they can be harnessed as a resource. It provides readers with a solid grasp of etiologic agents, pathogenic processes, epidemiology, and the role of microbes as therapeutic agents. Placing a major emphasis on omics technology, the book covers recent developments in the arena of microbes and discusses their role in industry and agriculture, as well as in related fields such as immunology, cell biology, and molecular biology. It offers complete discussions of the major bacterial, viral, fungal, and parasitic pathogens; includes information on emerging infectious diseases, antibiotic resistance, and bioterrorism; and talks about the future challenges in microbiology. The most complete treatment of microbial biology available, Microbes features eye-opening chapters on: Human and Microbial World Gene Technology: Application and Techniques Molecular Diagnostic and Medical Microbiology Identification and Classification of Microbes Diversity of Microorganisms Microbes in Agriculture Microbes as a Tool for Industry and Research Complete with charts and figures, this book is an invaluable textbook for university teachers, students, researchers, and people everywhere who care about microorganisms.

Adapting pedagogy to cultural context
Adapting pedagogy to cultural context

Author: Jovina Tibenda

Publisher: RTI Press

Published: 2021-09-23

Total Pages: 24

ISBN-13:

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This paper argues that many pedagogical reform efforts falter because they fail to consider the cultural context of teacher and student behavior. Little guidance exists on how to adapt teaching practices to be compatible with culturally influenced behaviors and beliefs. We present evidence from three studies conducted as part of a large basic education program in Tanzania showing that some teaching activities are less effective or not well implemented because of culturally influenced behaviors in the classroom, namely children’s lack of confidence to speak up in class; a commitment to togetherness, fairness, and cooperation; avoidance of embarrassment; and age-graded authority. We propose ways teaching activities can be adapted to take these behaviors into account while still adhering to fundamental principles of effective learning, including student participation in their own learning, teaching at the right level, and monitoring students as a basis for adjusting instruction. Such adaptations may be made most effective by engaging teachers in co-creation of teaching activities.

Eliciting stakeholder perceptions using a novel online engagement platform
Eliciting stakeholder perceptions using a novel online engagement platform

Author: Juliana M. Ruzante

Publisher: RTI Press

Published: 2022-01-19

Total Pages: 15

ISBN-13:

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Stakeholder engagement is an important component in developing policies on critical issues such as the use and development of novel methods and technologies, including biotechnologies and nanotechnologies. Understanding the perspectives, needs, and concerns of stakeholder groups can facilitate the development of transparent and trusted policy recommendations. Innovative online research platforms have been developed as alternatives to typical stakeholder engagement methods such as in-person focus groups, interviews, and online and paper surveys. These platforms facilitate the engagement of geographically and linguistically (i.e., individuals who speak different languages) diverse stakeholders using a wide range of methods, from virtual focus groups to surveys. Stakeholders can participate at their own leisure and anonymously, which can facilitate more open interactions on issues where viewpoints may differ. In this work, we used an online stakeholder engagement platform (OSEP) to engage stakeholders and capture their perceptions and views about the application of nanotechnology in food and agriculture (nano-agrifood) and the role of responsible innovation in the development of nano-agrifood products. The OSEP provided a reliable and interactive environment for stakeholders to share their views and exchange ideas. Such OSEPs should be further explored as novel tools for engaging stakeholders on a range of issues from emerging technologies to public health.

The Biology of Schistosomes
The Biology of Schistosomes

Author: D. Rollinson

Publisher:

Published: 1987

Total Pages: 472

ISBN-13: 9780125936927

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Due to their devastating impact on both human and animal health in numerous tropical countries of the world, schistosomes have become one of the most widely studied of parasitic organisms. The tremendous ongoing research and control effort, primarily directed at ridding man of the disease schistosomiasis, involves people from many different disciplines and backgrounds. The intention of this book is to draw together the many interesting advances in knowledge in diverse areas of study which relate to the biology of schistosomes, and to provide a standard and comprehensible text which will be of immediate benefit to advanced students, research workers, clinicians and field workers.