Chemical industries have to face the challenge of finding adequate processes to produce large quantities of new products, while at the same time decreasing both the impact on the environment and the risk of disaster. This book addresses this challenge. It discusses the problems of environmentally benign organic processes on an interdisciplinary approach. The book features experts in selective catalysis, development of new reagents and methods who present their recent results.
Recent years have seen huge growth in the area of sustainable chemistry. In order to meet the chemical needs of the global population whilst minimising impacts on health and the environment it is essential to keep reconsidering and improving synthetic processes. Sustainable Organic Synthesis is a comprehensive collection of contributions, provided by specialists in Green Chemistry, covering topics ranging from catalytic approaches to benign and alternative reaction media, and innovative and more efficient technologies.
Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. Highlights the need for adoption of sustainable and green chemistry pathways in drug development Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability
An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
Green Sustainable Process for Chemical and Environmental Engineering and Science: Sustainable Organic Synthesis provides an in-depth overview in the area of organic, pharmaceutical, engineering and environmental sciences, with a focus on the purification and extraction of fine chemicals, alternative green solvents, medicinal, analytical drugs, and bioactive compounds utilizing green chemistry protocols. It also focuses on the nanocatalysis, biocatalysis, solvent-free, recyclable organocatalysis, solid-supported reagents, heterogeneous polymer reusable catalysis, and CO2 conversion to commercial chemicals, utilizing industrial strategies such as flow-reactor, microwave, ultrasonics, ball-mill, photochemical and electrochemical methods. Covers a broad overview of sustainable organic synthesis Outlines eco-friendly organic synthesis using novel techniques and chemical processes, i.e., photochemical, electrochemical, microwave, bio-strategies, etc. Gives a detailed account of green, large-scale techniques in organic synthesis and their applications in pharmaceutical production Presents cutting-edge, recent advances in industrial pharmaceuticals and the technologies involved in medicinal and organic chemistry Provides a systematic discussion of each technology in organic synthesis, including main parameters and challenges
Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project
The last decade has seen a huge interest in green organic chemistry, particularly as chemical educators look to "green" their undergraduate curricula. Detailing published laboratory experiments and proven case studies, this book discusses concrete examples of green organic chemistry teaching approaches from both lecture/seminar and practical perspe
This book aims to stimulate and promote the wide-ranging aspects of green chemistry and its major role in ensuring sustainable development. The book covers the following areas: green chemistry; green reagents and atom economy; safeguarding the atmosphere; industrial green catalysis; alternative reaction conditions; biocatalysis and green chemistry. This book is based on the third edition of the Collection of Lectures of the Summer Schools on Green Chemistry held in Venice, Italy in the summers of 1998-2003 (sponsored by the European Commission, TMR and Improving Programmes and carried out by the Consortzio Interuniversitario La Chemica per l'Ambiente).
Nontraditional Activation Methods in Green and Sustainable Applications: Microwaves; Ultrasounds; Photo-, Electro- and Mechan-ochemistry and High Hydrostatic Pressure provides a broad overview of non-traditional activation methods to help readers identify and use appropriate approaches in reducing the environmental impact of their work. Sections discuss the fundamental principles of each method and provide examples of their practical use, illustrating their usefulness. Given the importance of expanding laboratory based technologies to the industrial level, chapters that cover both existing and potential industrial and environmental applications are also included. Highlighting the usefulness and adaptability of these methods for a range of practical applications, this book is a practical guide for both those involved with the design and application of synthetic methodologies and those interested in the implementation and impact of green chemistry principles in practice, from synthetic and medicinal chemists, to food developers and environmental policy planners. Discusses, and critically assesses, the advantages of non-traditional activation methods in green and sustainable chemistry applications Features individual chapters written by renowned experts in the field Contains extensive, state-of-the-art reference sections, providing critically filtered information to readers
