Biological Small Angle Scattering: Techniques, Strategies and Tips

Biological Small Angle Scattering: Techniques, Strategies and Tips

Author: Barnali Chaudhuri

Publisher: Springer

Published: 2017-12-07

Total Pages: 269

ISBN-13: 981106038X

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This book provides a clear, comprehensible and up-to-date description of how Small Angle Scattering (SAS) can help structural biology researchers. SAS is an efficient technique that offers structural information on how biological macromolecules behave in solution. SAS provides distinct and complementary data for integrative structural biology approaches in combination with other widely used probes, such as X-ray crystallography, Nuclear magnetic resonance, Mass spectrometry and Cryo-electron Microscopy. The development of brilliant synchrotron small-angle X-ray scattering (SAXS) beam lines has increased the number of researchers interested in solution scattering. SAS is especially useful for studying conformational changes in proteins, highly flexible proteins, and intrinsically disordered proteins. Small-angle neutron scattering (SANS) with neutron contrast variation is ideally suited for studying multi-component assemblies as well as membrane proteins that are stabilized in surfactant micelles or vesicles. SAS is also used for studying dynamic processes of protein fibrillation in amyloid diseases, and pharmaceutical drug delivery. The combination with size-exclusion chromatography further increases the range of SAS applications. The book is written by leading experts in solution SAS methodologies. The principles and theoretical background of various SAS techniques are included, along with practical aspects that range from sample preparation to data presentation for publication. Topics covered include techniques for improving data quality and analysis, as well as different scientific applications of SAS. With abundant illustrations and practical tips, we hope the clear explanations of the principles and the reviews on the latest progresses will serve as a guide through all aspects of biological solution SAS. The scope of this book is particularly relevant for structural biology researchers who are new to SAS. Advanced users of the technique will find it helpful for exploring the diversity of solution SAS methods and applications. Chapter 3 of this book is available open access under a CC BY 4.0 license at link.springer.com.


Elements of Slow-Neutron Scattering

Elements of Slow-Neutron Scattering

Author: J. M. Carpenter

Publisher: Cambridge University Press

Published: 2015-09-24

Total Pages: 539

ISBN-13: 0521857813

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This book provides a comprehensive and up-to-date introduction to the fundamental theory and applications of slow-neutron scattering.


Oak Ridge National Laboratory

Oak Ridge National Laboratory

Author: Leland Johnson

Publisher: Univ. of Tennessee Press

Published: 1994

Total Pages: 292

ISBN-13: 9780870498541

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Leland Johnson and Daniel Schaffer begin their narrative in 1943 when the U.S. Army Corps of Engineers built ORNL in the hills of East Tennessee to produce plutonium for atomic weapons. After World War II, ORNL became a center for fundamental scientific research under the successive management of the Atomic Energy Commission, the Energy Research and Development Administration, and the Department of Energy.


Nuclear Data for Science and Technology

Nuclear Data for Science and Technology

Author: Syed M. Qaim

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 1041

ISBN-13: 3642581137

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This book describes the Proceedings of the International Conference on Nuclear Data for Science and Technology held at Jillich in May 1991. The conference was in a series of application oriented nuclear data conferences organized in the past under the auspices of the Nuclear Energy Agency-Nuclear Data Committee (NEANDC) and with the support of the Nuclear Energy Agency-Committee on Reactor Physics (NEACRP). It was the fIrst international conference on nuclear data held in Germany, with the scientific responsibility entrusted to the Institute of Nuclear Chemistry of the Research Centre Jillich. The scientific programme was established by the International Programme Committee in consultation with the International Advisers, and the NEA and IAEA cooperated in the organization. A total of 328 persons from 37 countries and fIve international organizations participated. The scope of these Proceedings extends to a wide range of interdisciplinary topics dealing with measu rement, calculation, evaluation and application of nuclear data, with a major emphasis on numerical data. Both energy and non-energy related applications are considered and due attention is given to some fundamental aspects relevant to the understanding of nuclear data.


Neutron Scattering in Biology

Neutron Scattering in Biology

Author: Jörg Fitter

Publisher: Springer Science & Business Media

Published: 2006-01-10

Total Pages: 594

ISBN-13: 9783540291084

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The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.


The First Nuclear Era

The First Nuclear Era

Author: Alvin M. Weinberg

Publisher: Springer Science & Business Media

Published: 1994

Total Pages: 326

ISBN-13: 1563963582

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The autobiography of a highly influential nuclear engineer and scientist whose work began in the 1940s and continues today. He recounts his education, his role in the Manhattan Project, his stint as director of the Oak Ridge National Laboratory (1955- 73), and his subsequent work with both successful and unsuccessful commercial power reactors. Annotation copyright by Book News, Inc., Portland, OR


Neutron Radiography

Neutron Radiography

Author: Garbe,U.

Publisher: Materials Research Forum LLC

Published: 2020-02-05

Total Pages: 326

ISBN-13: 1644900572

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Neutron radiography represents a powerful non-destructive testing technique that is still very much in development. The book reveals the amazing diversity of scientific and industrial applications of this technique, the advancements of the state-of-art neutron facilities, the latest method developments, and the expected future of neutron imaging.


Research Needs in Subsurface Science

Research Needs in Subsurface Science

Author: National Research Council

Publisher: National Academies Press

Published: 2000-03-13

Total Pages: 186

ISBN-13: 0309172136

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Research Needs in Subsurface Science provides an overview of the subsurface contamination problems across the DOE complex and shows by examples from the six largest DOE sites (Hanford Site, Idaho Engineering and Environmental Laboratory, Nevada Test Site, Oak Ridge Reservation, Rocky Flats Environmental Technology Site, and Savannah River Site) how advances in scientific and engineering knowledge can improve the effectiveness of the cleanup effort. This report analyzes the current Environmental Management (EM) Science Program portfolio of subsurface research projects to assess the extent to which the program is focused on DOE's contamination problems. This analysis employs an organizing scheme that provides a direct linkage between basic research in the EM Science Program and applied technology development in DOE's Subsurface Contaminants Focus Area. Research Needs in Subsurface Science also reviews related research programs in other DOE offices and other federal agencies (see Chapter 4) to determine the extent to which they are focused on DOE's subsurface contamination problems. On the basis of these analyses, this report singles out the highly significant subsurface contamination knowledge gaps and research needs that the EM Science Program must address if the DOE cleanup program is to succeed.


Neutron Detectors for Scattering Applications

Neutron Detectors for Scattering Applications

Author: Yacouba Diawara

Publisher: Springer Nature

Published: 2023-08-04

Total Pages: 257

ISBN-13: 3031365461

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This book covers the most common neutron detectors used in neutron scattering facilities and all of those in use at Oak Ridge National Lab. It starts describing the facilities, instruments and the critical detector parameters needed by various instruments. Then the key components of the 3He-based linear position-sensitive detectors as well as on their electronics, which require particular attention to signal processing and noise reduction, are introduced. One chapter is dedicated to the 3He alternatives where scintillators play a critical role. It also covers emerging neutron detection technologies including semiconductors, vacuum-based devices and their associated readouts, which will be required in the future for high rate and high-resolution neutron detectors. The authors explain the logic behind the choice of materials as well as the various constraints that neutron detectors must respect to be useful. Some of these constraints, such as efficiency and gamma-ray sensitivity are common to all neutron counters while others, like timing resolution, dynamic range, and peak counting rate, depend on the applications. The book guides experts, the nuclear science community, and young scholars through the physical processes and the required electronics in a way that is accessible for those not professionally involved in designing detector’s components and electronic circuits.