Discovery and Development of Neuroprotective Agents from Natural Products
Discovery and Development of Neuroprotective Agents from Natural Products

Author: Goutam Brahmachari

Publisher: Elsevier

Published: 2017-05-18

Total Pages: 492

ISBN-13: 0128097698

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Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer's disease, Parkinson's disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. - Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery - Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases - Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Melatonin, Neuroprotective Agents and Antidepressant Therapy
Melatonin, Neuroprotective Agents and Antidepressant Therapy

Author: Francisco López-Muñoz

Publisher: Springer

Published: 2016-11-16

Total Pages: 917

ISBN-13: 8132228030

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This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .

Neuroprotective Therapy for Stroke and Ischemic Disease
Neuroprotective Therapy for Stroke and Ischemic Disease

Author: Paul A. Lapchak

Publisher: Springer

Published: 2017-01-12

Total Pages: 795

ISBN-13: 3319453459

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A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

Neuroprotective Effects of Phytochemicals in Neurological Disorders
Neuroprotective Effects of Phytochemicals in Neurological Disorders

Author: Tahira Farooqui

Publisher: John Wiley & Sons

Published: 2017-03-20

Total Pages: 662

ISBN-13: 1119155142

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Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.

Neuroprotective Agents
Neuroprotective Agents

Author: Russell J. Andrews

Publisher: Wiley-Blackwell

Published: 2010-07-19

Total Pages: 248

ISBN-13:

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Features some proceedings of the Ninth International Conference on Neuroprotective Agents.

Neuroprotective Agents and Cerebral Ischaemia
Neuroprotective Agents and Cerebral Ischaemia

Author:

Publisher: Academic Press

Published: 1996-11-26

Total Pages: 393

ISBN-13: 0080857744

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Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes. Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs. - Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode - Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents - Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs - Discusses the application of preclinical data to formulate approaches to a clinical problem - Provides detailed reviews of both completed clinical trials and those currently underway

Neuroprotection in Alzheimer's Disease
Neuroprotection in Alzheimer's Disease

Author: Illana Gozes

Publisher: Academic Press

Published: 2016-12-30

Total Pages: 344

ISBN-13: 0128037121

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Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics. - Comprehensive reference detailing neuroprotection in Alzheimer's Disease, with details on nerve cell protection and new advances in disease management - Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development - Edited by one of the leading researchers in Alzheimer's Disease

Neuroprotection
Neuroprotection

Author: Matilde Otero-Losada

Publisher: BoD – Books on Demand

Published: 2020-11-26

Total Pages: 350

ISBN-13: 1838804390

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Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Advances in Structure and Activity Relationship of Coumarin Derivatives
Advances in Structure and Activity Relationship of Coumarin Derivatives

Author: Santhosh Penta

Publisher: Academic Press

Published: 2015-08-07

Total Pages: 191

ISBN-13: 012803873X

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Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity. - Accessible and current coverage of coumarin derivatives from structure to potential applications - Application of SAR technology to predict bioactivity of the derivatives based on its chemical structure - Information for researchers in medicinal chemistry, pharmaceutical sciences, and related fields

Translational Research in Traumatic Brain Injury
Translational Research in Traumatic Brain Injury

Author: Daniel Laskowitz

Publisher: CRC Press

Published: 2016-04-21

Total Pages: 388

ISBN-13: 1498766579

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Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme