Gedenkboek der vaste keuringscommissie [van de] Koninklijke Nederlandsche Maatschappij voor tuinbouw en plantkunde 1889-1939
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Published: 1939
Total Pages: 99
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Published: 1939
Total Pages: 99
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Published: 1996
Total Pages: 0
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DOWNLOAD EBOOKThe addition of two floors to the existing building housing the LSU Eye Center and the Lions Eye Research Laboratories is now nearing completion. The Neuroscience Center will be occupying this space in February - March 1997. Plans for floors eight and nine have been included as an appendix of this volume. The additional space will greatly enhance the capabilities of the research program of the Neuroscience Center. Many components of the eight research projects, as well as the associated Core research facilities and administrative units, will be housed in the new space. The benefits of the synergy created by proximity in the development of exciting new approaches to research problems related with Neural Responses to Injury: Prevention, Protection, and Repair will soon be realized. The centralization of the Core Research Facilities will allow cooperative usage and simply oversight, reducing costs and eliminating duplication. Finally, the location of administrative functions in constant contact with the research facilities will permit efficient management and minimize wasteful miscommunication.
Author: Nicolas Bazan
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Published: 1996
Total Pages: 171
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DOWNLOAD EBOOKThe experimental animals used during this period for the project, Neural Responses to Injury: Prevention, Protection, and Repair, Subproject: Neurochemical Protection of the Brain, Neural Plasticity and Repair, are as follows: Species Number Allowed Number Used LSU IACUC# Rat (sprague-Dawle) 125 125 1046 Rat (Sprague-Dawle) 91 91 1045 The development of chronic epilepsy is a very serious complication of head injury, neurodegenerative diseases, brain tumors, and exposure to neurotoxic agents. Head injury is often associated with loss of short-term memory, indicating trauma to the hippocampal formation, the brain region most commonly associated with epileptic brain damage. Underlying the formation of epilepsy (epileptogenesis) is proposed to be a vicious cycle initiated by the loss of neurons. In an attempt to repair and/or replace lost synaptic connections, the brain can develop aberrant synaptic circuits that permit the propagation and amplification of waves of excitatory neurotransmission, eventually resulting in prolonged or repeated seizures (status epilepticus). The massive amounts of excitatory amino acids released during these episodes can stimulate further neuronal loss (excitotoxic damage), the formation of more aberrant synaptic circuits, and further seizures (Choi and Rothinan, 1990). Excitotoxic damage has been demonstrated in several experimental models of status epilepticus (Meldmm et al, 1973; Ben-Ari, 1995; Sloviter, 1987).
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Published: 1994
Total Pages: 34
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DOWNLOAD EBOOKThe LSU Neuroscience Center is a comprehensive, multidisciplinary, and transdepartmental entity that unites fundamental neurobiology and the clinical neurosciences in the common goal of elucidating the workings of the brain and contributing to the treatment of currently incurable diseases of the nervous system. The objective of the present program is to find solutions to neuroscience-related problems of interest to the U.S. Army Medical Research and Development Command. The program is focused on exploiting novel neuroprotective strategies that lead to prevention of and repair after neural injury. Converging approaches using state-of-the-art tools of cell biology, neurochemistry, neuroimmunology, neurophysiology, neuropharmacology, molecular biology and virology are proposed.
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Published: 1994
Total Pages: 169
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DOWNLOAD EBOOKThe LSU Neuroscience Center is a comprehensive, multidisciplinary, and transdepartmental entity that unites fundamental neurobiology and the clinical neurosciences in the common goal of elucidating the workings of the brain and contributing to the treatment of currently incurable diseases of the nervous system. The objective of the present program is to find solutions to neuroscience-related problems of interest to the U.S. Army Mo%%na3 Research and Development Command. The program is focused on exploiting novel neuroprotective strategies that lead to prevention of and repair after neural injury. Converging approaches using state-of-the-art tools of cell biology, neurochemistry, neuroimmunology, neurophysiology, neuropharmacology, molecular biology and virology are proposed. JMD.
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Published: 1994
Total Pages: 78
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DOWNLOAD EBOOKThe LSU Neuroscience Center is a comprehensive, multidisciplinary, and transdepartmental entity that unites fundamental neurobiology and the clinical neurosciences in the common goal of elucidating the workings of the brain and contributing to the treatment of currently incurable diseases of the nervous system. The objective of the present program is to find solutions to neuroscience-related problems of interest to the U.S. Army Medical Research and Development Command. The program is focused on exploiting novel neuroprotective strategies that lead to prevention of and repair after neural injury. Converging approaches using state-of-the-art tools of cell biology, neurochemistry, neuroimmunology, neurophysiology, neuropharmacology, molecular biology and virology are proposed. JMD.
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Published: 1996
Total Pages: 122
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DOWNLOAD EBOOKThe overall focus of this project has been to understand the cellular and molecular biology of neuroma formation as a complication of damage and repair to peripheral nerves. As part of this, a secondary focus has been to establish in vitro models of cell lines of fibroblasts from peripheral nerves that can be used to uncover the molecular mechanisms of peripheral nerve fibroblast response to damage and also to their interaction with cell signaling molecules that may be present in the repair process. A third objective has been to understand the origin of pain that accompanies neuroma formation. It has not been known how the cellular developments affect the physiology of the entrapped nerve endings. Electrophysiological and immunohistochemical studies have been carried out on human neuroma tissue to determine how the ion channels change as the neuroma develops.
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Published: 1998
Total Pages: 56
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DOWNLOAD EBOOKThe work on human neuromas, uncovering cellular and molecular events in neuroma formation and developing models of human neuroma, has proceeded with great productivity over the past year.
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Published: 1994
Total Pages: 198
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DOWNLOAD EBOOKThe SU Neuroscience Center is a comprehensive, multidisciplinary, and transdepartmental entity that unites fundamental neurobiology and the clinical neurosciences in the common goal of elucidating the workings of the brain and contributing to the treatment of currently incurable diseases of the nervous system. The objective of the present program is to find solutions to neuroscience-related problems of interest to the U.S. Army Medical Research and Development Command. The program is focused on exploiting novel neuroprotective strategies that lead to prevention of and repair after neural injury. Converging approaches using state-of-the-art tools of cell biology, neurochemistry, neuroimmunology, neurophysiology, neuropharmacology, molecular biology and virology are proposed. JMD.
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Published: 1996
Total Pages: 0
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DOWNLOAD EBOOKThe hypothesis on which this investigation is based is that stressors such as transient temperature changes and restraint signal the central nervous system eliciting the release of catecholamines and adrenal steroids which, in turn, affect the immune system resulting in the reactivation of latent viruses. Employing a mouse model of stress-induced reactivation of herpes simplex virus type 1 (HSV-1), we are determining the time course of viral reactivation relative to the alteration of immune parameters including lymphocyte functions and numbers. Specifically, we are correlating the expression of various immunomodulatory cytokine genes with the levels of neuroendocrine monoamines, as well as the activation of the hypothalamic-pituitary-adrenal (HPA) axis and relating these to the reactivation of infectious virus in the nervous system. Alterations in serum corticosterone and shifts in monoamines in the brains, trigeminal ganglia, and brain stems of latently infected and reactivated mice following the application of stress are being studied. Differences between control (not stressed) and stressed animals are being determined relative to the incidence of viral reactivation and the affect of stress on immunological regulation of the reactivation process.