Natural Products as Source of Molecules with Therapeutic Potential
Natural Products as Source of Molecules with Therapeutic Potential

Author: Valdir Cechinel Filho

Publisher: Springer

Published: 2018-12-07

Total Pages: 531

ISBN-13: 3030005453

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This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

Organizational Psychology and Evidence-Based Management
Organizational Psychology and Evidence-Based Management

Author: Elaine Rabelo Neiva

Publisher: Springer

Published: 2017-10-11

Total Pages: 299

ISBN-13: 3319643045

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Adopting an Evidence-Based Management (EBM) approach, this book provides the best evidence available on a wide range of topics from Industrial and Organizational Psychology to help managers base their decisions on scientific findings. Drawing on principles and methods first developed by Evidence-Based Medicine, EBM aims to promote the use of scientific knowledge in organizational and managerial decision making. Based on this idea, the book seeks to establish a dialogue between researchers and professionals of the Industrial and Organizational Psychology and Management fields, translating scientific knowledge into useful resources that can be used to inform practitioner’s decisions and interventions in topics such as: Creativity in organizations Optimism and hope Engagement at work Life and career planning Entrepreneurship Innovation in organizations Cultural diversity and inclusion in organizations Social networks Ageing at organizational context Work/life balance Positive rule breaking Expatriation Time pressure, Pacing styles and polychronicity

Otherworlds
Otherworlds

Author: David Luke

Publisher: Aeon Books

Published: 2019-05-24

Total Pages: 403

ISBN-13: 1916068979

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A comprehensive exploration of chemically mediated extra ordinary human experiences. Scientist and psychonaut David Luke weaves personal experience and scientific research to create Otherworlds - Psychedelics and Exceptional Human Experience. “Emphasizing parapsychological aspects of the psychedelic experience, Luke’s new book fills in a fascinating and previously neglected lacuna in the burgeoning field of human studies with these compounds. ” – Rick Strassman, PhD “A psychedelic Indiana Jones. ” – Matt Colborn, PhD “David Luke’s delightful one-liner about his book is that it’s ‘about weird people in weird places taking weird substances doing weird things and, importantly, having weird experiences’ . . . On reflection, it’s much more profound than that . . . So weird reader, forge ahead without fear. ” – Dean Radin, PhD “In his fascinating book David plunges into this controversial topic and gives the backstory, the front story, and possible ways forward to bring paranormal and psychedelic research together, and further our understanding of both. ” – Dennis J. McKenna, PhD “A remarkable collection and a necessary one. This body of research illuminates aspects of psychedelic experiences usually obscured or denied in the medical and clinical research and sensationalized in the popular press. ” – James Fadiman, PhD “A real Dr Gonzo. ” – Will Self

Drug Discovery and Development
Drug Discovery and Development

Author: Ramarao Poduri

Publisher: Springer Nature

Published: 2021-02-15

Total Pages: 522

ISBN-13: 9811555346

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This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Methods for Preclinical Evaluation of Bioactive Natural Products
Methods for Preclinical Evaluation of Bioactive Natural Products

Author: Ipek Suntar

Publisher: Bentham Science Publishers

Published: 2023-06-27

Total Pages: 314

ISBN-13: 981512305X

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Natural products have dominated our lives since ancient times. Today, they are an inexhaustible source of new medications for disease treatment. The practice of evaluating bioactive compounds extracted from natural sources has also advanced significantly, prompting a need to understand current methods to identify and evaluate them. This book covers basic scientific aspects of preclinical research on natural products for specific conditions and diseases. These include aging, gynecological disorders, inflammatory disorders, renal disorders and cardiovascular disorders. Each of the 10 book chapters give a structured overview on preclinical methods on the etiology of diseases, natural products as the materials for the bioassays, extract types, concentration of the extracts/compounds for in vitro and in vivo assays, preparation of the test materials, application of the test materials, step-by-step methods and related calculations. The book is intended as a quick reference for natural product researchers, pharmacists and postgraduate students in pharmacognosy. Medical doctors working in preclinical research on natural products will also benefit from the information provided.

Kinase Drug Discovery
Kinase Drug Discovery

Author: Richard A. Ward

Publisher: Royal Society of Chemistry

Published: 2019

Total Pages: 430

ISBN-13: 1788010833

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Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations. The evolving biology of kinases has also resulted in increased interest in the immuno-oncology area and also pseudokinases as a target family. As with the first volume the book finishes with a forward looking view of how research against this fascinating target class may evolve.