Nanovaccines
Nanovaccines

Author: Sergio Rosales-Mendoza

Publisher: Springer Nature

Published: 2019-11-07

Total Pages: 347

ISBN-13: 3030316688

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This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases. Since nanomaterials possess unique properties; many of them have a positive effect on vaccine efficacy when used as antigen carriers and have been applied in vaccinology with significant advances over the past years. This book addresses the methodologies for mucosal nanovaccines synthesis; based on the following nanomaterials: gold, PLGA, silica, and chitosan nanoparticles; as well as nanogels, carbon nanotubes, liposomes, and Virus-like particles. A description of the immunogenic properties of the mucosal nanovaccines is presented, highlighting the improvements achieved with this approach when compared to conventional formulations. Mucosal vaccines constitute the most practical immunization approach since they are easy to administer (promoting patient ́s comfort and increasing compliance), allow triggering relevant immune responses at both the site of administration and distant compartments, and thus may protect the main entry portal for pathogens (oral, nasal, and genital mucosae). In this context, the potential of nanovaccines to result in new mucosal formulations in the benefit of global health is analyzed. Covers the synthesis and functionalization of nanomaterials for the development of nanovaccines; Discusses the underlying mechanisms involved in the induction of immune responses through mucosal compartments and the advantages of nanomaterials in the formulation of nanovaccines; Transmits the state of the art for the development of mucosal nanovaccines; Provides routes for the design and evaluation of mucosal nanovaccines; Presents key perspectives for the field of mucosal vaccine development.

Emerging Nanotechnologies in Immunology
Emerging Nanotechnologies in Immunology

Author: Ranjita Shegokar

Publisher: William Andrew

Published: 2018-05-17

Total Pages: 291

ISBN-13: 0323401139

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Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body.The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use. - Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals which are currently under research - Focuses on the characterization and quantification of the nanopharmaceuticals - Allows readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects - Includes an overview of regulatory aspects related to the R&D of nanopharmaceuticals

Nanovaccinology as Targeted Therapeutics
Nanovaccinology as Targeted Therapeutics

Author: Kaushik Pal

Publisher: John Wiley & Sons

Published: 2022-06-14

Total Pages: 356

ISBN-13: 111985802X

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NANOVACCINOLOGY AS TARGETED THERAPEUTICS The book presents the early-stage development of nanovaccines that could well be the new generation of vaccines which have a great potential for the prevention and treatment of many diseases. Nanovaccinology as Targeted Therapeutics explores recent breakthroughs in the exciting new field of micro- and nanofabricated engineered nanomaterials. In addition to spectroscopic characterizations, significant topics for interdisciplinary research, especially in the fields of nanogels, which deal with polymer chemistry, nanotechnology, materials science, pharmaceuticals, and medicine are explored, where their small dimensions prove highly advantageous. Nanovaccinology could potentially revolutionize conventional therapy and diagnostic methods due to its superior effectiveness over its macro-sized counterparts in almost all biomedical areas. Strong interest in this novel class of material has driven many studies to discover biogenic production methods and new areas of potential utilization in this area. Therefore, it is important to keep abreast of the development of these biomedical research aspects highlighted in the 19 chapters of this book written in diverse fields of studies, and their emerging applications utilized in next-generation techniques. Audience Biotechnologists, nanotechnologists, materials scientists, biochemists, medical biologists, drug delivery and formulation chemists, virologists and pharmacists.

Micro- and Nanotechnology in Vaccine Development
Micro- and Nanotechnology in Vaccine Development

Author: Mariusz Skwarczynski

Publisher: William Andrew

Published: 2016-09-20

Total Pages: 462

ISBN-13: 0323400299

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This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. - Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development - Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development - Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Nanostructures for Oral Medicine
Nanostructures for Oral Medicine

Author: Ecaterina Andronescu

Publisher: Elsevier

Published: 2017-04-11

Total Pages: 1036

ISBN-13: 0323477216

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Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. - Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied - Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine - Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices

Fish Vaccines
Fish Vaccines

Author: Preetham Elumalai

Publisher: CRC Press

Published: 2023-06-30

Total Pages: 263

ISBN-13: 1000879402

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Key Features: Reviews the status of vaccine use in aquaculture. Describes formulations, strategies and innovations in fish vaccines. Covers aspects like safety concerns, ethical approvals and regulations. Includes topics like societal impact and vaccine reach to fish farmers. Discusses different adjuvants for vaccine efficacy.

Nanovaccinology
Nanovaccinology

Author: Kaushik Pal

Publisher: Springer Nature

Published: 2023-09-23

Total Pages: 361

ISBN-13: 3031353951

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This book provides an overview of the cumulative work on a driving force for innovation in medicine and modern healthcare, boosting advances in therapeutics, biosensors, vaccines, and clinical systems. The work presented shows how nanoparticles have been investigated as vaccine adjuvants because they possess chemical and structural properties that improve immunogenicity as well as the use of nanotechnology in the construction of immunization systems that has developed into the field of viral nanovaccinology. The volume highlights potential areas of research, innovation, and development of finished products for future commercialization and significant research exploration through nanoparticles that prove capable of surmounting most of the barriers like toxicity issues, clearance from biological system, DNA instability, and differences in expression systems. The contributing authors review the primary literature on principles, limitations, and recent breakthroughs in nanoparticle-based antigen delivery vehicles, their use in different diseases, the major bottlenecks, and related issues. Highlighting advances in nanoparticle engineering and the understanding of nanoparticle characteristics as well as critical legacy work dome in the field of nanobiotechnology, the book is ideal for a range of researchers and students in the pure and applied sciences devoted to nanomaterials, vaccinology, and translational medicine.

Handbook of Nanomaterials, Volume 2
Handbook of Nanomaterials, Volume 2

Author: Muhammad Imran Malik

Publisher: Elsevier

Published: 2024-01-17

Total Pages: 901

ISBN-13: 0323955142

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Handbook of Nanomaterials: Biomedicine, Environment, Food, and Agriculture offers a comprehensive resource that introduces the role of nanotechnology and nanomaterials in a broad range of areas, covering fundamentals, methods, and applications.In this volume, dedicated sections focus on key applications across biomedicine, environmental remediation, food, agriculture, and other areas. In each chapter, detailed but concise information is provided on a specific application, and other key state-of-the-art technologies such as biomimetic nanotechnology and nanotechnology in 3D printing are included. In the final part of the book, there is in-depth coverage of environmental and regulatory issues relating to nanotechnology.This book is of interest to researchers and advanced students approaching nanotechnology from a range of disciplines, including materials science and engineering, chemistry, chemical engineering, electronics, energy, biomedicine, environmental science, food science, and agriculture, as well as scientists, engineers, and R&D professionals with an interest in the use of nanomaterials across a range of industries. - Introduces the reader to key applications of nanomaterials - Provides broad, systematic, concise coverage, supporting readers from a range of disciplines - Covers applications across biomedicine, environmental remediation, food, agriculture, and more