A mutant tortured and barely alive. A woman restrained by a society she no longer trusts. When Khalisa first sets eyes on the barely conscious mutant, Zielle, she isn’t prepared for the anguish within at seeing firsthand what the scientists in the Dome’s facility are doing to the ‘monsters’ who live outside the air-cleansed compound. But then she’s always rebelled against the rules. Always questioned and defied everything she’s been told since she and her brother, Dwight, were captured and saved from outside, where the chemical fallout would have turned them mutant too. What she and her brother don’t know is that they are dormant mutants whose powers are yet to be triggered. They are also the last hope of saving a mutant clan, whose leader, Zielle, volunteers to be captured by the evil humans so that he can find and rescue the mutant siblings. But it’s only Khalisa he can free, and on the run from the humans who’d do anything possible to recapture them, he has to convince Khalisa that he’s on her side…and that the sizzling chemistry between them is just an added bonus.
The dragons have searched the universe to find their one true mate… Twelve months has been and gone. The Riddich dragons are finally reunited and have brought with them their Earth mates. All too soon they form a plan with their unlikely, newfound friends. They'll land on the icy planet of Tantonic, their mission: to kill the evil Tantonic Queen and her soldiers, and release any surviving prisoners. But can the heat loving Riddich Dragons survive the cold and outwit the vicious Tantonic Queen who all but wiped out their mighty race? Or will they perish, or worse, be drained of their powers before they've even had a chance to avenge their fallen people?
Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field. Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown. The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.
Rb and Tumorigenesis examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle. This book will interest cell biologists, graduate students and researchers.
The Biochemistry of Plants, Volume 15: Molecular Biology presents information pertinent to gene expression, cytoskeletal proteins, and hydroxyproline-rich glycoprotein. This book discusses the specific gene systems and examines the regulatory regions within the genes. Organized into 17 chapters, this volume starts with an overview of the important mechanism for regulating gene expression, which is significant in the selective turnover of gene products. This book then proceeds with a discussion of the concept of protein degradation and the extracellular carriers of genetic information. Other chapters review the viral and plasmid systems, which are relevant to plants. This text discusses as well the phenotypic changes in plants, including plant genetic tumor and habituated plant tissues that exhibit hormone autotrophic growth. The final chapter examines the importance of genetic manipulation at the cellular level via protoplast fusion, cell selection, and transformation. Biologists, biochemists, enzymologists, biophysicists, and plant scientists will find this book extremely useful.
Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.
Described as the earliest, simplest life forms, with unlimited metabolic versatility, bacteria are ideally suited to answer some very fundamental questions on life and its processes. They have been employed in almost all fields of biological studies, including Genetics. The whole edifice of science of Genetics centers around three processes: the generation, expression, and transmission of biological variation, and bacteria offer immediate advantages in studying all the three aspects of heredity. Being haploid and structurally simple, it becomes easy to isolate mutations of various kinds and relate them to a function. The availability of such mutants and their detailed genetic and biochemical analyses lead to a gamut of information on gene expression and its regulation. While studying the transmission of biological variation, it is clear that unlike their eukaryotic counterpart, a more genetic approach needs to be employed. Transmission of genetic information in most eukaryotic organisms rests on sexual reproduction that allows the generation of genetically variable offspring through the process of gene recombination. Even though bacteria show an apparent preference for asexual reproduction, they too have evolved mechanisms to trade their genetic material. In fact, bacteria not only could acquire many genes from close relatives, but also from entirely distant members through the process of horizontal gene transfer. Their success story of long evolutionary existence will stand testimony to these mechanisms. While teaching a course on Microbial Genetics to the post-graduate students at Delhi University, it was realized that a book devoted to bacterial genetics may be very handy to the students, researchers, and teachers alike. A strong foundation in genetics also helps in comprehending more modern concepts of molecular biology and recombinant DNA technology, always a favorite with the students and researchers. Planning the format of the book, emphasis has been laid on the generation and transmission of biological variability. The omission of expression part is indeed intentional because lots of information is available on this aspect in any modern biology book. The contents are spread over seven chapters and the text is supported with figures/tables wherever possible. The endeavor has been to induce the readers to appreciate the strength of bacterial genetics and realize the contribution of these tiny organisms to the growth of biological sciences as a whole and genetics in particular.
Interdependence between species is a law of nature. The degree of this interdependence is vividly evident in the plant-microbial world. Indeed, there is no axenic plant in nature and one finds various forms of interac tions between these two kingdoms ranging from completely innocuous to obligate parasitic. Most of these interactions are poorly understood at the molecular and physiological levels. Only those few cases for which a molecular picture is emerging are discussed in this volume. With the advent of recombinant DNA technology and the realization that some of these interactions are very beneficial to the host plant, a spate of activity to understand and manipulate these processes is occurring. Microbes interact with plants for nutrition. In spite of the large number of plant-microbe interactions, those microbes that cause harm to the plants (i. e. , cause disease) are very few. It is thus obvious that plants have evolved various defense mechanisms to deal with the microbial world. The mecha nisms for protection are highly diverse and poorly understood. Some pathogens have developed very sophisticated mechanisms to parasitize plants, an excellent example for this being crown gall caused by a soil bac terium, Agrobacterium tumefaciens. A remarkable ingenuity is exhibited by this bacterium to manipulate its host to provide nitrogenous compounds which only this bacterium can catabolize. This is carried out by a direct gene transfer mechanism from bacteria to plants.
