Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants
Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Author: Micheline Kirsch-Volders

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 348

ISBN-13: 1461326435

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This book is intended for anyone who cares about the health of people exposed to industrial pollutants. Attention is given to those pollutants which present a possible risk to the genetic material of exposed workers. Chapters are devoted to heavy metals such as arsenic, beryllium, cadmium, chromium, lead, mercury, nickel, etc.; insecticides (chlorinated, organophosphorus, and carbonate insecticides); monomers such as vinyl-chloride, acrylonitrile, styrene, vinylidene chloride, butadiene, chlorobutadiene, hexachlorobuta diene, etc.; and halogenated hydrocarbon solvents such as chloroform, carbon tetrachloride, trichloroethylene, I, 2-dichloroethane, tetrachloroethyl ene, dichloromethane, and I, I, I-trichloroethane. The main aim of this work is to provide the physician, the biologist, the pharmacologist, or anyone involved in genetic toxicology with a useful compendium of up-to-date information and references. Efforts are made to open the field to nonspecialists. An introductory chapter deals with the mechanisms whereby a given compound, reaching genetic material, either directly or indirectly, may increase the risk of a cancer developing in the exposed individual and of abnormalities being passed on to his or her progeny. Efforts are also made to allow easy and efficient reading for those who are not interested in detailed results. Comparative tables provide the following data on the compounds studied: chemical properties, production, occurrence, accepted standards in the industry, and positive or negative results with different test systems. Finally, senior research workers might find good descriptions in this book of the most recent results from mutagenesis and carcinogenesis testing in plant, nonmammalian, and mammalian systems.

How Tobacco Smoke Causes Disease
How Tobacco Smoke Causes Disease

Author: United States. Public Health Service. Office of the Surgeon General

Publisher:

Published: 2010

Total Pages: 728

ISBN-13:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Occupational Toxicology
Occupational Toxicology

Author: Chris Winder

Publisher: CRC Press

Published: 2004-02-11

Total Pages: 624

ISBN-13: 1482289288

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Hazardous agents are an ongoing concern in the modern workplace, with many examples of workers being severely affected by chemicals as a result of both acute and chronic exposure. Occupational Toxicology, 2nd Edition introduces the basics of toxicology that underpin the application of toxicological information to the workplace environment.

Molecular Modeling and Prediction of Bioactivity
Molecular Modeling and Prediction of Bioactivity

Author: Klaus Gundertofte

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 490

ISBN-13: 1461541417

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Much of chemistry, molecular biology, and drug design, are centered around the relationships between chemical structure and measured properties of compounds and polymers, such as viscosity, acidity, solubility, toxicity, enzyme binding, and membrane penetration. For any set of compounds, these relationships are by necessity complicated, particularly when the properties are of biological nature. To investigate and utilize such complicated relationships, henceforth abbreviated SAR for structure-activity relationships, and QSAR for quantitative SAR, we need a description of the variation in chemical structure of relevant compounds and biological targets, good measures of the biological properties, and, of course, an ability to synthesize compounds of interest. In addition, we need reasonable ways to construct and express the relationships, i. e. , mathematical or other models, as well as ways to select the compounds to be investigated so that the resulting QSAR indeed is informative and useful for the stated purposes. In the present context, these purposes typically are the conceptual understanding of the SAR, and the ability to propose new compounds with improved property profiles. Here we discuss the two latter parts of the SARlQSAR problem, i. e. , reasonable ways to model the relationships, and how to select compounds to make the models as "good" as possible. The second is often called the problem of statistical experimental design, which in the present context we call statistical molecular design, SMD. 1.

Clinical and Experimental Toxicology of Organophosphates and Carbamates
Clinical and Experimental Toxicology of Organophosphates and Carbamates

Author: Bryan Ballantyne

Publisher: Elsevier

Published: 2017-01-31

Total Pages: 662

ISBN-13: 1483193659

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Clinical & Experimental Toxicology of Organophosphates and Carbamates considers the histochemical localization of cholinesterase in anticholinesterase poisoning. This book is organized into eight parts encompassing 59 chapters that discuss the pharmacology and toxicology of carbamates, as well as the neurobehavioral toxicology of anticholinesterases. Some of the topics covered in the book are the overview of biological and clinical aspects of organophosphates and carbamates; biochemical determination of cholinesterase activity in fluids and tissues; intermediate syndrome in anticholinesterase neurotoxicity; structure-activity relationships and anticholinesterase activity; and the molecular events in delayed neuropathy. Other parts deal with the cardiac effects of anticholinesterase agents and the ecotoxicological consequences of interactions between avian esterases and organophosphorus compounds. These topics are followed by discussions on the analysis of the cutaneous and respiratory tract absorption of anticholinesterases and the use of organophosphorus compounds as chemical warfare agents. The final parts are devoted to the toxicity of anticholinesterases to aquatic organisms. The book can provide useful information to toxicologists, doctors, students, and researchers.

Teratogens
Teratogens

Author: Vera M. Kolb

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 595

ISBN-13: 1483193225

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Teratogens Chemicals Which Cause Birth Defects, 2nd Revised Edition is a collection of papers that discusses the practical aspect of teratogens, particularly regarding information on the teratogenic potential of chemicals. This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and the role of bio-activation in teratogenesis. Investigations have been done on the relationship between spontaneous abortion in women exposed to organic solvents, antineoplastic agents, and chemicals in plastics. Other studies also show that teratogenicity depends in part on enzymatic bio-activation to an embryotoxic reactive intermediate. This text also explains the legal and ethical aspects of fetal protection policies with emphasis on fetal protection. Protection to expecting women extends to pregnant students exposed to teratogenic chemicals in chemistry laboratories. The book explains how and where to get information about the teratogenic potential of chemicals and how to properly handle these chemicals in the laboratory. The book also provides a list from RTECs of toxic chemicals which can cause reproductive effects. This book can prove useful for chemists, pharmacologists, obstetricians, gynecologists, and practitioners of general medicine.

Air Pollution
Air Pollution

Author: Arthur C. Stern

Publisher: Academic Press

Published: 2014-06-28

Total Pages: 538

ISBN-13: 0080926061

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Subjects extensively covered include asbestos, carbon dioxide, lead, nuclear accidents, non-ionizing radiation, stratospheric ozone, and visibility. This state-of-the-art compilation will facilitate the work of air pollution control agency personnel, air pollution research scientists, and air pollution consultants. It will also be useful to law firms involved in air pollution litigation and to air pollution equipment and instrument manufacturers. - Acidic deposition (acid rain) - Indoor air pollution - Long range transport - Risk assessment and management - Hazardous and toxic substances

Hazardous Wastes
Hazardous Wastes

Author: Richard J. Watts

Publisher: John Wiley & Sons

Published: 2023-06-27

Total Pages: 724

ISBN-13: 1119634067

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Hazardous Wastes An illuminating, problem-solving approach to source area analysis, environmental chemodynamics, risk assessment, and remediation In the newly revised second edition of Hazardous Wastes: Assessment and Remediation, a team of distinguished researchers delivers a foundational and comprehensive treatment of all aspects of hazardous waste problems. The book offers two sections—one on assessment and the following on remediation—while exploring topics crucial to the study of environmental science and engineering at the senior or master’s level. This latest edition includes a new emphasis on the chemistry of emerging contaminants, including perfluorinated compounds, 1,4-dioxane, methyl tert-butyl ether, and personal care products. It also offers updated data on contaminant Threshold Limit Value, Reference Dose, Slope Factor, Reference Concentration, and Inhalation Unit Risk. New remediation chapters also provide many design problems, incorporating economic analyses and the selection of various design alternatives. Approximately 200 new end-of-chapter problems—with solutions—have been added as well. Readers will also find: A thorough introduction to hazardous wastes, including discussion of pre-regulatory disposal and hazardous waste legislation Comprehensive discussions of common hazardous wastes, including their nomenclature, industrial uses, and disposal histories In-depth explorations of partitioning, sorption, and exchange at surfaces, as well as volatilization Extensive descriptions of the concepts of hazardous waste toxicology and quantitative toxicology Perfect for senior- and masters-level college courses in hazardous wastes in Environmental Science, Environmental Engineering, Civil Engineering, or Chemical Engineering programs, Hazardous Wastes: Assessment and Remediation will also earn a place in the libraries of professional environmental scientists and engineers.