Encyclopedia of Signaling Molecules

Encyclopedia of Signaling Molecules

Author: Sangdun Choi

Publisher: Springer

Published: 2012-07-09

Total Pages: 0

ISBN-13: 9781441904607

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Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.


Reactive Oxygen Species

Reactive Oxygen Species

Author: Harald H. H. W. Schmidt

Publisher: Springer Nature

Published: 2021-02-23

Total Pages: 425

ISBN-13: 3030685101

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Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.


The Endothelium

The Endothelium

Author: Michel Félétou

Publisher: Morgan & Claypool Publishers

Published: 2011

Total Pages: 309

ISBN-13: 1615041230

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The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References


Index Medicus

Index Medicus

Author:

Publisher:

Published: 2004

Total Pages: 2388

ISBN-13:

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.


MRCOG Part One

MRCOG Part One

Author: Alison Fiander

Publisher: Cambridge University Press

Published: 2016-10-13

Total Pages: 557

ISBN-13: 1107667135

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A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.


Anesthesia for Congenital Heart Disease

Anesthesia for Congenital Heart Disease

Author: Dean B. Andropoulos

Publisher: John Wiley & Sons

Published: 2023-03-13

Total Pages: 1076

ISBN-13: 1119791650

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Anesthesia forCongenital Heart Disease An Extensive Reference Work Detailing the Procedures, Knowledge, and Approaches in Anesthesia for Congenital Heart Disease In this fourth edition of Anesthesia for Congenital Heart Disease, a distinguished group of expert authors in congenital heart disease (CHD) from all over the world provide a thorough, comprehensive, and fully updated overview of the specifics of congenital heart disease and the intricacies involved with administering anesthetic care to patients who suffer from the myriad of lesions encompassed by CHD. In the seven years since the third edition of Anesthesia for Congenital Heart Disease was published, an explosion of new procedures, approaches, and patients eligible for anesthetic care has occurred. The goal of Anesthesia for Congenital Heart Disease, Fourth Edition is to help readers understand all of the recent advancements and developments in the field while also imparting a foundation of essential historical knowledge. The book contains new chapters that reflect exciting new approaches in this rapidly changing field, and also includes: Updated information in the chapter Adult Congenital Heart Disease and Mechanical Support of the Circulation, reflecting the increasing prominence of these patients in CHD care New chapters on Informatics and Artificial Intelligence, Genetic Syndromes, Point of Care Ultrasound, and Cardiopulmonary Resuscitation in Congenital Heart Disease Thorough updates of all chapters with many new figures and tables, and hundreds of new recent references provide up to date information Anesthesia for Congenital Heart Disease, Fourth Edition serves as a thorough and in-depth reference work and is an essential resource for practitioners providing perioperative care to CHD patients.


Calcium and Cell Function

Calcium and Cell Function

Author: Wai Yiu Cheung

Publisher: Academic Press

Published: 2013-10-22

Total Pages: 222

ISBN-13: 1483217493

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Calcium and Cell Function, Volume 7 covers the signal transduction across the cell membrane. The book discusses phosphoinositides and calcium signaling; calmodulin-stimulated adenylate cyclases; and calcium/calmodulin-dependent protein kinases. The text also describes the regulation of gene expression by calcium; the dynamics of intracellular calcium concentration during mitosis; and the methods for the measurement of intracellular ionized calcium in mammalian cells. Pharmacologists, physiologists, and people involved in the study of calcium and cell function will find the book invaluable.


Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author: National Research Council

Publisher: National Academies Press

Published: 2000-12-21

Total Pages: 348

ISBN-13: 0309070864

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Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.