Behavioral Genetics of the Mouse: Volume 2, Genetic Mouse Models of Neurobehavioral Disorders
Behavioral Genetics of the Mouse: Volume 2, Genetic Mouse Models of Neurobehavioral Disorders

Author: Susanna Pietropaolo

Publisher: Cambridge University Press

Published: 2014-09-25

Total Pages: 471

ISBN-13: 131606140X

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The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes
Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes

Author: Wim E. Crusio

Publisher: Cambridge University Press

Published: 2013-04-25

Total Pages: 361

ISBN-13: 1107355575

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The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

I Moved Your Cheese
I Moved Your Cheese

Author: Deepak Malhotra

Publisher: Berrett-Koehler Publishers

Published: 2013-09-02

Total Pages: 70

ISBN-13: 1609940679

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The author of Negotiating the Impossible “tackles our assumptions about business and life with humor, zest, and wisdom in this delightful fable” (Daniel H. Pink, New York Times-bestselling author). If you were a mouse trapped in a maze and someone kept moving the cheese, what would you do? In a world where most mice dutifully accept their circumstances, ask no questions, and keep chasing the cheese, Deepak Malhotra tells an inspiring story about three unique and adventurous mice—Max, Big, and Zed—who refuse to accept their reality as given. I Moved Your Cheese reveals what is possible when we finally discard long-held and widely accepted assumptions about how we should live our lives. After all, achieving extraordinary success, personal or professional, has always depended on the ability to challenge assumptions, reshape the environment, and play by a different set of rules—our own. But rejecting deeply ingrained beliefs is not easy. As Zed explains, “You see, Max, the problem is not that the mouse is in the maze, but that the maze is in the mouse.” “Deepak Malhotra allows you to glimpse a world of your own making without the limits and barriers that others create.” —Stephen R. Covey, New York Times-bestselling author of The 7 Habits of Highly Effective People “A magnificent story with a powerful message. As someone who has encouraged scores of professionals into breaking through the maze and defining their own pursuits, I find this to be a gem of a book.” —Vinod Khosla, cofounder, former CEO and Chairman, Sun Microsystems, and founder, Khosla Ventures “This book’s message is both profound and durable. Malhotra has left the maze, and so can we.” —Foreword Reviews

What's Wrong With My Mouse?
What's Wrong With My Mouse?

Author: Jacqueline N. Crawley

Publisher: John Wiley & Sons

Published: 2007-03-23

Total Pages: 540

ISBN-13: 0471471925

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Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Biology of Cognitive Aging: Model Systems, Technologies and beyond
Biology of Cognitive Aging: Model Systems, Technologies and beyond

Author: Shin Murakami

Publisher: Frontiers Media SA

Published: 2017-04-13

Total Pages: 147

ISBN-13: 2889451445

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Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer’s disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves “old” memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D.

Engineering Technology, Engineering Education and Engineering Management
Engineering Technology, Engineering Education and Engineering Management

Author: Deyao Tan

Publisher: CRC Press

Published: 2015-06-25

Total Pages: 1213

ISBN-13: 1315683156

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This volume contains papers presented at the International Conference on Engineering Technologies, Engineering Education and Engineering Management (ETEEEM 2014, Hong Kong, 15-16 November 2014). A wide variety of topics is included in the book: - Engineering Education - Education Engineering and Technology - Methods and Learning Mechanism

Degenerative Disorders of the Brain
Degenerative Disorders of the Brain

Author: Darren Hocking

Publisher: Routledge

Published: 2019-04-05

Total Pages: 283

ISBN-13: 135120890X

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Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects. Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer’s disease and other dementias, Parkinson’s disease and related disorders, and Huntington’s disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation. Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.

Annual Review of Gerontology and Geriatrics, Volume 21, 2001
Annual Review of Gerontology and Geriatrics, Volume 21, 2001

Author: Vincent J. Cristofalo, PhD

Publisher: Springer Publishing Company

Published: 2001-11-14

Total Pages: 313

ISBN-13: 0826116094

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Presenting the latest research in the biology of aging, this volume addresses important theoretical issues focusing on the basis for why humans live as long as they do. Expert authors combine three general paradigms of aging research: demographic studies, evolutionary studies, and studies of biological mechanisms. Topics explored include: Why does aging occur? Cellular aging Models in aging research Modern approaches to the mechanisms of aging The genetics of behavioral aging

The Molecular Pathology of Cognitive Decline: Focus on Metals
The Molecular Pathology of Cognitive Decline: Focus on Metals

Author: Paul A. Adlard

Publisher: Frontiers Media SA

Published: 2016-02-02

Total Pages: 177

ISBN-13: 2889197204

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In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.