Veterinary Psychopharmacology
Veterinary Psychopharmacology

Author: Sharon L. Crowell-Davis

Publisher: John Wiley & Sons

Published: 2008-02-28

Total Pages: 288

ISBN-13: 0470344148

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Every day veterinarians in practice are asked to treat petsexhibiting problem behaviors. In the last several yearspharmacologic treatments of behavior have made significant advancesand can serve as a critical part of therapy. Veterinary Pscyhopharmacology is a complete source of currentknowledge on the subject of pharmacologic behavior modificationthat veterinarians can turn to for the answers they need. Classification of disorders is eschewed in favor of in-depthexplanations of pharmacologic options in inducing behavior changes.Special emphasis is given to explaining the underlying mechanism ofpharmacologic agents used in therapy; thus, veterinarians will knownot only which drugs to prescribe but why they should be prescribedand how they work. Veterinary behaviorists, their students and residents, veterinarypractitioners of all levels, and veterinary students will find thisbook invaluable in providing information about their patients'behavior problems and the psychoactive medications that might helpthem.

Monoamine Oxidase Enzymes
Monoamine Oxidase Enzymes

Author: Lars Oreland

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 178

ISBN-13: 3709189012

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The papers in this volume are the invited lectures at the Second Workshop on Amine Oxidases held at the Biomedical Center, Uppsala University, 2 to 4 August 1986. It was a great pleasure for the organizers to see, in Uppsala, so many old and new friends, all brought together by our common interest in the fascinating field of Amine Oxidases. The Workshop was the successor of a long row of successful predecessors to start with the 1972 meeting in Cagliari, Sardinia, and recently preceded by the first meeting of Workshop design, held in Cambridge 1984. Several of the previous meetings have been dedicated to distinguished senior research workers within the field. To start this Workshop a memorial lecture was given. This lecture, given by Prof. T. P. Singer, was dedicated to the late Prof. K. Kamijo, who was one of the pioneers of what is now worldwide interest in Amine Oxidases and who organized the superb meeting in Hakone 1981. To the great honour of all the participants the family of the late Prof. Kamijo visited the Workshop. Abstracts of all the presentations have been published as a Supplement of Acta Pharmacologica et Toxicologica (Copenhagen).

Monoamine Oxidase
Monoamine Oxidase

Author: Hajime Yasuhara

Publisher: VSP

Published: 1993-01-01

Total Pages: 260

ISBN-13: 9789067641463

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Monoamine oxidase (MAO), a mitochondrial enzyme which metabolizes monoamines in both the central nervous system and peripheral tissues, plays an important role in the regulation of neuronal activities by controlling the concentrations of monoamines. During the past three decades the enzymological properties of MAO have been studied extensively. The most exciting and important advances in these studies have been the determination of the nucleotide sequence coding two forms of human MAO (MAO-A and MAO-B), and the involvement of MAO in potent dopaminergic neurotoxicity of MPTP, which had led to the acceleration of aetiological studies of Parkinson's disease. Other aspects of MAO studies have been the application of selective and safe MAO inhibitors in the treatment of depression and Parkinson's disease as well as the correlation between MAO and several psychiatric and neurodegenerative disorders.

Monoamine Oxidase
Monoamine Oxidase

Author: Claudia Binda

Publisher: Springer Nature

Published: 2022-09-28

Total Pages: 259

ISBN-13: 1071626434

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This detailed book examines the main methods to study mammalian monoamine oxidases (MAOs), ranging from cell biology to computational chemistry. Beginning with techniques on how to obtain pure samples of MAO A and MAO B, the volume continues by covering assays and techniques used to measure MAO enzymatic activity and perform inhibition studies, methods to address cellular localization and function of MAOs, either in cell lines or in animal models, as well as computational methods applied to rational drug design approaches that are used to develop new MAO inhibitors. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Monoamine Oxidase: Methods and Protocols serves as a vital resource for scientists who are interested in studying MAOs and other similar amine oxidase enzymes.

Monoamine Oxidase Inhibitors
Monoamine Oxidase Inhibitors

Author: Sushil K. Sharma

Publisher: Nova Science Publishers

Published: 2016

Total Pages: 0

ISBN-13: 9781634836005

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This book provides basic and applied knowledge about monoamine oxidase inhibitors (MAOIs), their classification, and clinical application as neuroprotective agents and will be a valuable source of new knowledge for doctors, patients, medical students, teachers, researchers, and basic biomedical scientists interested in learning the appropriate clinical application of MAOIs without any misunderstanding for the prevention and/or treatment of neurological and neuropsychiatric disorders. The book will be of immediate interest to patients suffering from Parkinson's disease (PD), Alzheimer's disease (AD), post-traumatic stress disorders (PTSD), panic disorders, attention deficit hyperactivity disorders (ADHD), and major depression. Physicians interested in learning more about MAOIs and their molecular and pharmacological mechanism of action will highly benefit from the book's clinically-interesting contents. In general, this book will be a valuable source of knowledge for the basic researcher, clinically useful for the physician, and therapeutically-beneficial for the patients. The book can also serve as a guide for Masters and Ph.D students interested in conducting research on MAOIs. Particularly, MD doctors, students, and professors will find this book interesting to enhance their basic knowledge about MAOIs and their potential benefits and adverse effects for the better clinical management of drug-resistant PD, AD, and MDDs. Furthermore, recent knowledge regarding the molecular mechanism of MAOIs-mediated protection at the cellular, molecular, and genetic level is thought-provoking and motivates the young scientists to augment research on developing novel drugs with minimum or no adverse effects. It is envisaged that future research on specific CB-targeted MAOIs will have superior pharmacogenomics profiles, enhanced margin of safety, maximum therapeutic index, and minimum or no adverse effects.'

Monoamine Oxidases and their Inhibitors
Monoamine Oxidases and their Inhibitors

Author:

Publisher: Academic Press

Published: 2011-10-05

Total Pages: 298

ISBN-13: 0123864682

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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. In this volume, invited experts provide authoritative reviews on various aspects of Monoamine Oxidase and its Inhibitors. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Monoamine Oxidase Inhibitors in Neurological Diseases
Monoamine Oxidase Inhibitors in Neurological Diseases

Author: Lieberman

Publisher: CRC Press

Published: 1994-01-12

Total Pages: 408

ISBN-13: 9780824790820

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Emphasizing the role of monoamine oxidase (MAO) in the etiology and pathogenesis of Parkinson's disease and Alzheimer's disease, this up-to-date reference describes the genetics, physiology, biochemistry, pharmacology, and clinical aspects of this very important class of enzymes. Details how the interaction between selegiline (deprenyl) and MAO may retard the progression of neurodegenerative disorders! Providing the latest theories on how selegiline operates, Monoamine Oxidase Inhibitors in Neurological Diseases presents fundamental information on MAO types A and B examines the distribution of MAO A and B in the normal human brain investigates the effects of disease and aging on MAO A and B analyzes a critical role for MAO in the toxic action in Parkinson's disease elucidates selegiline's novel ability to delay the progression or repair the damage of dopaminergic neurons discusses the usefulness of MAO inhibitors in psychiatric disease and more!

Monoamine Oxidases and Their Selective Inhibition
Monoamine Oxidases and Their Selective Inhibition

Author: K. Magyar

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 171

ISBN-13: 148314786X

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Monoamine Oxidases and Their Selective Inhibition, Volume IV, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The discovery of the selective monoamine oxidase (MAO) inhibitors, such as clorgyline and deprenyl, has given a new impetus to MAO research as well as to the clinical applicability of these compounds. This volume contains 21 papers by researchers and clinicians from eight different countries. It begins with papers on the pharmacological effects and the biochemical mode of actions of deprenyl as well as some other new selective inhibitors. This is followed by communications concerning the biochemical methods applied in the study of the nature of MAO in the mitochondrial membrane. Finally, the neurologists provide an account of their experience with the clinical application of deprenyl, and other inhibitors in Parkinsonian patients. They also discuss the essential role of the dopaminergic mechanism with respect to the disease.

Oxidative Stress in Heart Diseases
Oxidative Stress in Heart Diseases

Author: Sajal Chakraborti

Publisher: Springer Nature

Published: 2019-11-06

Total Pages: 596

ISBN-13: 9811382735

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This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.