Arousal states are processes that include waking, deep sleep, and the dreaming phase of sleep (REM). Molecular Regulation of Arousal States explores the cellular and molecular mechanisms by which sleep and wakefulness are regulated and seeks explanations for the generation of arousal states. It presents step-by-step research protocols that allow investigators to apply the techniques described to a wide range of physiological and behavioral research problems, such as sleep neurobiology and state-dependent disruption of cardiopulmonary control. For the first time, a single source integrates cellular and molecular research techniques with studies of arousal, opening the door to exciting new research methodologies.
Handbook of Behavioral State Control: Cellular and Molecular Mechanisms provides the first synthesis of information on the neurobiology of behavioral states, ranging from normal stress and sleep deprivation to debilitating neuropsychiatric disorders. This book presents a working reference on the cellular and molecular mechanisms generating arousal states; pharmacological and non-pharmacological methods of behavioral state control; and the bi-directional interaction between arousal state and the neurobiology of pain, and between sleep and the immune system.
Arousal states are processes that include waking, deep sleep, and the dreaming phase of sleep (REM). Molecular Regulation of Arousal States explores the cellular and molecular mechanisms by which sleep and wakefulness are regulated and seeks explanations for the generation of arousal states. It presents step-by-step research protocols that allow investigators to apply the techniques described to a wide range of physiological and behavioral research problems, such as sleep neurobiology and state-dependent disruption of cardiopulmonary control. For the first time, a single source integrates cellular and molecular research techniques with studies of arousal, opening the door to exciting new research methodologies.
The new understanding of the relationships between gene expression and human experience emerging from the Human Genome Project is setting the stage for a profound expansion of our understanding of life. The new neuroscience discoveries about enriching life experiences, neurogenesis, and gene expression are poised to profoundly expand our understanding of psychotherapy and the holistic healing arts. We are just beginning to learn how the brain, the body, and our genes interact in ordinary everyday life to create our lives. Here, acclaimed author and pioneer of new approaches to mindbody communication Ernest Rossi introduces the new science of psychosocial genomics and explores how it will profoundly change our understanding of the pathways of communication among mind, body, and spirit. Integrating modern molecular medicine with traditional holistic healing art and spiritual rites, Rossi documents dramatically new approaches to optimize creativity in psychotherapy and therapeutic hypnosis with both individuals and groups. Part I reviews significant leading-edge neuroscience research on the psychobiology of gene expression and neurogenesis that leads to a new vision of the role of consciousness and creativity in the humanities and the healing arts. Part II explores how to creatively facilitate the psychodynamics of gene expression, neurogenesis, and healing in therapeutic hypnosis, psychotherapy, and human relationships in general. The Psychobiology of Gene Expression illustrates, step-by-step, how to facilitate the natural four-stage creative process on all levels from mind to molecule in our daily work of building a better brain. The book demonstrates how we can use our consciousness and our perception of free will to co-create ourselves in cooperation with nature. Rossi proposes practical approaches to optimize the natural cycles of gene expression in normal consciousness, sleep, dreaming, meditation, and the arts of daily living that are experienced by everyone. A case study spanning two chapters, containing dialog and explanatory commentary, brings the author's work to life and gives readers a deeper appreciation of its clinical application. Rossi's lucid writing style and vivid illustrations inspire this text with a new vision of the creative arts, humanities, and culture in facilitating the optimal development of health, performance, and consciousness.
There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.
This book describes some of the many different disciplines that are involved in investigations of neuroendocrine control mechanisms. It is intended for students, pre- and post-doctoral fellows, medical residents and others who are interested in neuroendocrine research.
