Molecular Pharming
Molecular Pharming

Author: Allison R. Kermode

Publisher: John Wiley & Sons

Published: 2018-05-08

Total Pages: 495

ISBN-13: 1118801288

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A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.

Frontiers in Molecular Pharming
Frontiers in Molecular Pharming

Author: Muhammad Sarwar Khan

Publisher: Bentham Science Publishers

Published: 2021-12-09

Total Pages: 413

ISBN-13: 981503667X

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The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Molecular Farming
Molecular Farming

Author: Rainer Fischer

Publisher: John Wiley & Sons

Published: 2006-03-06

Total Pages: 338

ISBN-13: 3527605819

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Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels. Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.

Frontiers in Molecular Pharming
Frontiers in Molecular Pharming

Author: Muhammad Sarwar Khan

Publisher: Bentham Science Publishers

Published: 2021-12-09

Total Pages: 415

ISBN-13: 9789815036688

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The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Molecular Farming in Plants: Recent Advances and Future Prospects
Molecular Farming in Plants: Recent Advances and Future Prospects

Author: Aiming Wang

Publisher: Springer Science & Business Media

Published: 2011-10-14

Total Pages: 284

ISBN-13: 9400722176

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Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.

Molecular Farming
Molecular Farming

Author: Rainer Fischer

Publisher: Wiley-Blackwell

Published: 2004-10-25

Total Pages: 344

ISBN-13:

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Índice: Preface. 1. Efficient and Reliable Production of Pharmaceuticals in Alfalfa 2. Foreign Protein Expression Using Plant Cell Suspension and Hairy Root Cultures 3. Novel Sprouting Technology for Recombinant Protein Production 4. Monocot Expression Systems for Molecular Farming 5. The Field Evaluation of Transgenic Crops Engineered to Produce Recombinant Proteins 6. Plant Viral Expression Vectors: History and New Developments 7. Production of Pharmaceutical Proteins in Plants and Plant Cell Suspension Cultures 8. Chloroplast Derived Antibodies, Biopharmaceuticals and Edible Vaccines 9. Plant derived vaccines: progress and constraints 10. Production of Secretory IgA in Transgenic Plants 11. Production of Spider Silk Proteins in Transgenic Tobacco and Potato 12. Gene Farming in Pea Under Field Conditions 13. Host Plants, Systems and Expression Strategies for Molecular Farming 14. Downstream Processing of Plant derived Recombinant Therapeutic Proteins 15. Glycosylation of Plant made Pharmaceuticals 16. Bi.

Molecular Farming in Plants: Recent Advances and Future Prospects
Molecular Farming in Plants: Recent Advances and Future Prospects

Author: Aiming Wang

Publisher: Springer

Published: 2011-10-21

Total Pages: 280

ISBN-13: 9789400722187

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Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.

Pharming
Pharming

Author: Eckard Rehbinder

Publisher: Springer Science & Business Media

Published: 2008-09-27

Total Pages: 341

ISBN-13: 3540857931

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A recently established technique termed pharming uses genetically modified plants and animals for the production of biopharmaceuticals. The present interdisciplinary study comprises an extended overview of the state of the art of pharming, as well as in depth analyses of the environmental risks and other ethical and legal issues of pharming. Public attitudes to pharming are investigated on the basis of an original survey in 15 countries worldwide. The study concludes with specific recommendations addressed towards science, industry and politics.