Cellular and Molecular Mechanisms of Breast Cancer Metastasis to the Brain
Author: Christoph B. Wyss
Publisher:
Published: 2016
Total Pages: 165
ISBN-13:
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Author: Christoph B. Wyss
Publisher:
Published: 2016
Total Pages: 165
ISBN-13:
DOWNLOAD EBOOKAuthor: Qifeng Yang
Publisher: Frontiers Media SA
Published: 2022-03-18
Total Pages: 274
ISBN-13: 2889747298
DOWNLOAD EBOOKAuthor: Leah Marie Cook
Publisher:
Published: 2011
Total Pages: 150
ISBN-13:
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Publisher:
Published: 19??
Total Pages:
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DOWNLOAD EBOOKMaterial in the Australian performing arts programs and ephemera (PROMPT) collection consists of programs and related items for Australian performing arts organisations, Australian artists performing overseas, professional productions performed in Australia (including those featuring overseas performers) and overseas performances of Australian plays, music, etc.
Author: Georg F. Weber
Publisher: Springer Science & Business Media
Published: 2007-09-12
Total Pages: 643
ISBN-13: 1402060165
DOWNLOAD EBOOKThis book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
Author: Antonella Zannetti
Publisher: Frontiers Media SA
Published: 2021-09-30
Total Pages: 566
ISBN-13: 2889714489
DOWNLOAD EBOOKAuthor: Masakazu Toi
Publisher: Frontiers Media SA
Published: 2022-09-27
Total Pages: 205
ISBN-13: 2832500854
DOWNLOAD EBOOKAuthor: Thomas Morgan Bodenstine
Publisher:
Published: 2010
Total Pages: 136
ISBN-13:
DOWNLOAD EBOOKAuthor: Yusuf Tutar
Publisher:
Published: 2019
Total Pages: 0
ISBN-13:
DOWNLOAD EBOOKBreast cancer (BC) is one of the most frequently occurring diseases with high morbidity and mortality rates in the world today. BC cells live under stress with altered pathway signaling, chromosome and microsatellite instability, aneuploidy, hypoxia, low pH, and low nutrient conditions. In order to survive and reproduce in these stressful environments, BC cells rapidly undergo adaptive mutations, rearrange their chromosomes, and repress tumor suppressor genes while inducing oncogene activities that cause the natural selection of cancer cells and result in heterogeneous cancer cells in the tumor environment. Unfortunately, these genetic alterations result in aggressive BC cells that can not only proliferate aggressively but also migrate and invade the other tissues in the body to form secondary tumors. In this review, molecular mechanisms of metastasis of BC subtypes are discussed.
Author: Aamir Ahmad
Publisher: Springer Nature
Published: 2019-08-27
Total Pages: 427
ISBN-13: 3030203018
DOWNLOAD EBOOKResistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.