Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research

Author: Robert T. Gerlai

Publisher: Academic Press

Published: 2018-04-24

Total Pages: 710

ISBN-13: 0128041161

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Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts

Handbook of Molecular-Genetic Techniques for Brain and Behavior Research
Handbook of Molecular-Genetic Techniques for Brain and Behavior Research

Author: Wim E. Crusio

Publisher: Elsevier

Published: 1999-10-18

Total Pages: 994

ISBN-13: 0080536867

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The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.

Methods in Genomic Neuroscience
Methods in Genomic Neuroscience

Author: Hemin R. Chin

Publisher: CRC Press

Published: 2001-09-26

Total Pages: 432

ISBN-13: 100061171X

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The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco

Behavior Genetics of Cognition Across the Lifespan
Behavior Genetics of Cognition Across the Lifespan

Author: Deborah Finkel

Publisher: Springer Science & Business Media

Published: 2013-07-09

Total Pages: 306

ISBN-13: 1461474477

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Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception. Francis Galton’s 1874 examination of eminent families in Britain was among the earliest attempts to investigate whether cognitive achievements run in families. This volume presents current methodologies for understanding cognitive abilities that move beyond the outdated nature vs. nurture paradigm. Recent advances in both collection and statistical modeling of twin data, particularly longitudinal twin data, make this an especially advantageous moment to produce a work that presents a collection of the groundbreaking research on cognitive abilities across the lifespan. This volume presents an overview of the current state of quantitative and molecular genetic investigations into the many facets of cognitive performance and functioning across the lifespan.​

Neurobehavioral Genetics
Neurobehavioral Genetics

Author: Byron C. Jones

Publisher: CRC Press

Published: 2002-01-01

Total Pages: 416

ISBN-13: 9781420048384

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Neurobehavioral Genetics: Methods and Applications covers classic and contemporary approaches to the study of the brain and behavior, including basic and clinical research. This book is designed as a reference for investigators wishing to incorporate genetic methods into neurobehavioral research. A broad spectrum of methods are integrated, unlike any other publication currently in print. Neurobehavioral Genetics: Methods and Applications presents different models, from invertebrates to genetically defined mammals. Introductory chapters demonstrate the scope and power of genetic methods that can be applied to neurobehavioral research from statistical methods and linkage analysis to contemporary molecular genetic approaches to search for candidate genes. The second half of the book covers the applications of quantitative and molecular genetics in basic and clinical research. Topics covered include animal behavior and neurobiology and human clinical problems including neurodegenerative diseases and psychiatric disorders.

Genes, brain, and emotions
Genes, brain, and emotions

Author: Andrei C. Miu

Publisher: Oxford University Press

Published: 2019-04-04

Total Pages: 464

ISBN-13: 0192511424

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The study of emotions has rapidly expanded in recent decades, incorporating interdisciplinary research on the genetic underpinnings and neural mechanisms of emotion. This has involved a wide range of methods from as varied fields as behavioral genetics, molecular biology, and cognitive neuroscience, and has allowed researchers to start addressing complex multi-level questions such as: what is the role of genes in individual differences in emotions and emotional vulnerability to psychopathology, and what are the neural mechanisms through which genes and experience shape these emotion? Genes, Brain, and Emotions: Interdisciplinary and translational perspectives offers a comprehensive account of this interdisciplinary field of research, bridging psychology, genetics, and neuroscience, with rich sections dedicated to methods, cognitive and biological mechanisms, and psychopathology. Written by leading researchers who have each inspired new research directions and innovated methods and concepts, this book will be of interest to anyone working or studying in the field of affective science, whether they be behavioural geneticists, psychologists and psychiatrists, or cognitive neuroscientists.

Genes, Brain Function, and Behavior
Genes, Brain Function, and Behavior

Author: Douglas Wahlsten

Publisher: Academic Press

Published: 2019-03-14

Total Pages: 299

ISBN-13: 012812833X

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Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior. Presents essential background, facts, and terminology about genes, brain function, and behavior Builds clear explanations on this solid foundation while minimizing technical jargon Explores in depth several single-gene and chromosomal neurological disorders Derives lessons from these clear examples and highlights key lessons in boxes Examines the intricacies of complex traits that involve multiple genetic and environmental factors by applying lessons from simpler disorders Explains diagnosis and definition Includes a companion website with Powerpoint slides and images for each chapter for instructors and links to resources

Foundations of Behavior Genetics
Foundations of Behavior Genetics

Author: Scott F. Stoltenberg

Publisher: Cambridge University Press

Published: 2022-07-07

Total Pages: 443

ISBN-13: 1108858368

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Foundations of Behavior Genetics provides a forward-looking introduction to this fascinating field. Written by an experienced teacher and researcher, this text focuses on concepts, methods, and findings that inform our understanding of heredity–behavior relations. The book's neuroscience perspective asks students to think about potential neural mechanisms involved in pathways from genes to behavior. While the text is primarily focused on human behavior genetics, it also emphasizes the importance of non-human animal models in experimental studies, as well as their evolutionary connections to humans. Part I covers the history of behavior genetics and the basics of non-molecular genetics; Part II discusses molecular genetics and neurogenetics; Part III addresses various behavioral disorders; and Part IV explores health, social behavior, and ethical implications. The text includes detailed chapter summaries, several “Check-up” questions after major sections that test student understanding, and recommended readings. Instructors are provided with a test bank of multiple-choice items and hi-res JPEGs of the many illustrations created for the book.

Principles of Behavioral Genetics
Principles of Behavioral Genetics

Author: Robert R.H. Anholt

Publisher: Academic Press

Published: 2009-09-21

Total Pages: 345

ISBN-13: 0080919898

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Principles of Behavioral Genetics provides an introduction to the fascinating science that aims to understand how our genes determine what makes us tick. It presents a comprehensive overview of the relationship between genes, brain, and behavior. Introductory chapters give clear explanations of basic processes of the nervous system and fundamental principles of genetics of complex traits without excessive statistical jargon. Individual chapters describe the genetics of social interactions, olfaction and taste, memory and learning, circadian behavior, locomotion, sleep, and addiction, as well as the evolution of behavior. Whereas the focus is on genetics, neurobiological and ecological aspects are also included to provide intellectual breadth. The book uses examples that span the gamut from classical model organisms to non-model systems and human biology, and include both laboratory and field studies. Samples of historical information accentuate the text to provide the reader with an appreciation of the history of the field. This book will be a valuable resource for future generations of scientists who focus on the field of behavioral genetics. Defines the emerging science of behavioral genetics Engagingly written by two leading experts in behavioral genetics Clear explanations of basic quantitative genetic, neurogenetic and genomic applications to the study of behavior Numerous examples ranging from model organisms to non-model systems and humans Concise overviews and summaries for each chapter

The Fundamentals of Modern Statistical Genetics
The Fundamentals of Modern Statistical Genetics

Author: Nan M. Laird

Publisher: Springer Science & Business Media

Published: 2010-12-13

Total Pages: 226

ISBN-13: 1441973389

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This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.