Parasite Neuromusculature and Its Utility as a Drug Target

Parasite Neuromusculature and Its Utility as a Drug Target

Author: Aaron G. Maule

Publisher: Cambridge University Press

Published: 2006-10-19

Total Pages: 208

ISBN-13: 9780521691789

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Nerve and muscle systems in helminth parasites interact in a highly co-ordinated manner to control movements associated with alimentation, reproduction, locomotion and attachment. All metazoan parasites rely on some or all of these activities for their survival. For a long time it has been known that neuromuscular function in parasites is susceptible to chemotherapeutic attack, and that compromising this aspect of parasite biology is sufficient to cure many parasite infections. This volume outlines the latest research in this area, showing why this system is so amenable to drug intervention and outlining potential targets for new treatments. Written by experts in the field, this volume will be invaluable to anyone interested in the molecular biology, physiology and biochemistry of parasites as well as those looking to exploit these for the creation of new treatments.


The Physiology and Biochemistry of Free-living and Plant-parasitic Nematodes

The Physiology and Biochemistry of Free-living and Plant-parasitic Nematodes

Author: Roland N. Perry

Publisher: Cabi

Published: 1998

Total Pages: 472

ISBN-13:

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"Written by leading research workers from Europe, USA, Australia and New Zealand, this is the only up-to-date reference book which reviews and integrates all the current research findings on the physiology and biochemistry of these organisms, including the molecular information which has accumulated in recent years.


Biochemistry and Molecular Biology of Parasites

Biochemistry and Molecular Biology of Parasites

Author: Joseph Marr

Publisher: Elsevier

Published: 1995-09-06

Total Pages: 363

ISBN-13: 0080527884

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The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the way for the treatment and prevention of the diseases they cause. Biochemistry and Molecular Biology of Parasites presents an up-to-date account of this modern scientific discipline in a manner that allows and encourages the reader to place the biochemistry and molecular biology of these organisms in their biological context. The chapters are cross-referenced and grouped in an arrangement that provides a fully integrated whole, and permits the reader to create a composite of the biochemical function of these organisms. Individual chapter includes those devoted to metabolism, in both aerobic and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are discussed not only from the point of view of their cellular biochemistry and metabolism, but also with respect to both their integrated functions such as neurochemistry, structure and functions of surfaces, and reproduction. Written by expert investigators, this book will be of interest to all experienced researchers, graduate students, and to the newcomer eager to become familiar with the biochemistry and molecular biology of parasites.


Practical Exercises in Parasitology

Practical Exercises in Parasitology

Author: D. W. Halton

Publisher: Cambridge University Press

Published: 2001-03-22

Total Pages: 488

ISBN-13: 9780521791045

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An excellent practical guide to hands-on teaching of parasitology in the laboratory.


Comparative Biochemistry of Parasitic Helminths

Comparative Biochemistry of Parasitic Helminths

Author: Eva Bennett

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 183

ISBN-13: 9400908334

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When Professor John Sprent first suggested, in 1982, that the Australian Society for Parasitology should bid for the opportunity to mount the Sixth International Congress of Parasitology, the immediate reaction was one of disbelief. However, in the two years or so before ICOPA 5, in Toronto, he used his considerable powers to the utmost and spent himself unstintingly in persuading Australian parasitologists to put together a bid. The Society inevitably agreed, for it is difficult to prevent such a determined and eminent man from getting his own way! A case for an Australian venue was prepared and, as President, I was charged with the task of convincing the delegates in Toronto that Australia was worth going all the way to see. The events of that meeting are now far in the past; suffice to say that, in the end, Australia won by the narrowest of margins, largely due to the energy of my inventive colleagues who put the case for Australia at every possible and improbable moment. I do not remember a great deal about the scientific aspects of ICOPA 5. I was far too preoccupied with an awful spectre, that of telling John Sprent that I had failed, to pay attention to much other than lobbying for votes. I do remember, however, telling myself how much I would enjoy the next ICOPA without the terrible responsibility of capturing ICOPA 7.


The Oxford Handbook of Invertebrate Neurobiology

The Oxford Handbook of Invertebrate Neurobiology

Author: John H. Byrne

Publisher: Oxford University Press

Published: 2019-01-29

Total Pages: 608

ISBN-13: 0190456787

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Invertebrates have proven to be extremely useful model systems for gaining insights into the neural and molecular mechanisms of sensory processing, motor control and higher functions such as feeding behavior, learning and memory, navigation, and social behavior. A major factor in their enormous contributions to neuroscience is the relative simplicity of invertebrate nervous systems. In addition, some invertebrates, primarily the molluscs, have large cells, which allow analyses to take place at the level of individually identified neurons. Individual neurons can be surgically removed and assayed for expression of membrane channels, levels of second messengers, protein phosphorylation, and RNA and protein synthesis. Moreover, peptides and nucleotides can be injected into individual neurons. Other invertebrate model systems such as Drosophila and Caenorhabditis elegans offer tremendous advantages for obtaining insights into the neuronal bases of behavior through the application of genetic approaches. The Oxford Handbook of Invertebrate Neurobiology reviews the many neurobiological principles that have emerged from invertebrate analyses, such as motor pattern generation, mechanisms of synaptic transmission, and learning and memory. It also covers general features of the neurobiology of invertebrate circadian rhythms, development, and regeneration and reproduction. Some neurobiological phenomena are species-specific and diverse, especially in the domain of the neuronal control of locomotion and camouflage. Thus, separate chapters are provided on the control of swimming in annelids, crustaea and molluscs, locomotion in hexapods, and camouflage in cephalopods. Unique features of the handbook include chapters that review social behavior and intentionality in invertebrates. A chapter is devoted to summarizing past contributions of invertebrates to the understanding of nervous systems and identifying areas for future studies that will continue to advance that understanding.


Physiology of Parasites

Physiology of Parasites

Author: Leslie H. Chappell

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 237

ISBN-13: 1468478087

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THIS BOOK HAS BEEN DEVELOPED FROM A SHORT LECTURE COURSE GIVEN to advanced undergraduate students as part of a general introduction to the subject of parasitology for zoologists. The book is written for the undergraduate who has no previous experience of parasitology and little background in either biochemistry or physiology. It is not a long book, and students will have to consult some of the more detailed textbooks in parasitology and physiology to gain a full understanding of the topics considered here. My objective in writing this book is to introduce the breadth of parasite physiology, leaving the reader to obtain a depth of knowledge by his own library research. Each chapter covers a single topic or related topics in physiological parasitology, and the variable length of the chapters reflects the amount of research interest that has been generated over the last few decades. It is to be hoped that by use of this book students will develop an interest in some of the more neglected areas and be stimulated to make good some of the more glaring deficiencies in our current knowledge. I should like to acknowledge with gratitude the assistance of my colleagues Dr 1. Barrett, Dr R. A. Klein, Dr A. W. Pike and Dr R. A.


The Pentose Phosphate Pathway

The Pentose Phosphate Pathway

Author: Terry Wood

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 217

ISBN-13: 0323160018

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The Pentose Phosphate Pathway aims to explore the pentose phosphate cycle and the practical techniques applied in its investigation. The main focus of the book is the pentose phosphate cycle in animals as well as microorganisms, and does not discuss the one related to photosynthesis. The book covers the formulation of the pathway, its types, and its alternative formulations; the preparation, processes, and analysis of the pathway; and the enzymes involved. Also covered in the book are the intermediates in intact cells and tissues; distribution of enzymes among different tissues and species; the operation, regulation, and overall control of the pathway; and the clinical, nutritional, and metabolic aspects of the pathway. The text is recommended for biologists and biochemists who would like to understand further the pentose phosphate pathway and the processes related to it.