Molecular Basis and Emerging Strategies for Anti-aging Interventions
Molecular Basis and Emerging Strategies for Anti-aging Interventions

Author: Syed Ibrahim Rizvi

Publisher: Springer

Published: 2018-11-02

Total Pages: 386

ISBN-13: 9811316996

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This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Emerging Anti-Aging Strategies
Emerging Anti-Aging Strategies

Author: Syed Ibrahim Rizvi

Publisher: Springer Nature

Published: 2023-01-30

Total Pages: 345

ISBN-13: 9811974438

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The book focuses on the emerging anti-aging approaches for maintaining better health in old age. It provides a current understanding of the underlying principle, possible targets, implementation approaches, and efficacy of the various anti-aging strategies. The chapters include a wide range of topics incorporating the major advances in anti-aging strategies, including telomerase activation, stem cell therapy, autophagy induction, sirtuin activation, and dietary restrictions. Further, it discusses the epigenetic mechanisms underlying aging-related processes and epigenetic strategies to delay and reverse aging-related diseases. The book covers the strategy based on tissue engineering and regenerative medicine for understanding the complexity of aging and restoring the functionalities of organ systems. It further presents the applications of melatonin supplementation-based anti-aging therapeutic intervention. Finally, the book reviews the ethical dimension of anti-aging intervention strategies. This book is immensely useful to scientists and researchers from various disciplines in the life sciences.

Aging Interventions And Therapies
Aging Interventions And Therapies

Author: Suresh I S Rattan

Publisher: World Scientific

Published: 2005-05-06

Total Pages: 427

ISBN-13: 9814481513

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This comprehensive volume surveys the molecular, cellular, hormonal, nutritional, medical and lifestyle strategies being tested and applied for the prevention, intervention and treatment of age-related diseases. With authoritative contributions not just from researchers in academic institutions and pharmaceutical and cosmeceutical industries, but also practicing clinicians of both mainstream and alternative medicine, demographers and bioethicists, this book provides unique scientific, ethical and social perspectives on the discussion of aging intervention. In addition, the latest technologies in development, which will have serious bearings on future aging interventions, are reviewed.Aging Interventions and Therapies is ideal for graduates and undergraduates in universities and medical and nursing colleges, as well as post-graduates researching different aspects of aging and anti-aging. The topics covered are also highly relevant for professionals in the pharmaceutical, cosmeceutical, nutrition and healthcare industries, and practicing clinicians looking for a reliable and up-to-date resource on aging intervention and therapy.

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging
Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

Author: Sandeep Kumar Singh

Publisher: Elsevier

Published: 2022-07-29

Total Pages: 410

ISBN-13: 0323902359

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Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals. Covers different aspects of anti-aging research, from foundational knowledge to future perspectives Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

Molecular Basis of Aging
Molecular Basis of Aging

Author: Arun K. Roy

Publisher:

Published: 1984

Total Pages: 424

ISBN-13:

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Molecular Basis of Aging is a collection of papers that discuss the molecular aspects of aging in the light of molecular biology, biochemical gerontology, and genetics. Each chapter of the book contains a different study about the topic, which includes the effects of aging on DNA synthesis; the amplification of extrachromosomal circular copies and mitochondrial DNA during aging; and the altered actions of hormones and neurotransmitters during aging. The book also encompasses the loss of responsiveness to growth factors in cell senescence; the integration of cellular-molecular and neuroendocrin ...

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging
Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

Author: Sandeep Kumar Singh

Publisher: Academic Press

Published: 2022-07-19

Total Pages: 411

ISBN-13: 0323902367

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Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals. Covers different aspects of anti-aging research, from foundational knowledge to future perspectives Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

Data-Driven Approach for Bio-medical and Healthcare
Data-Driven Approach for Bio-medical and Healthcare

Author: Nilanjan Dey

Publisher: Springer Nature

Published: 2022-10-27

Total Pages: 238

ISBN-13: 9811951845

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The book presents current research advances, both academic and industrial, in machine learning, artificial intelligence, and data analytics for biomedical and healthcare applications. The book deals with key challenges associated with biomedical data analysis including higher dimensions, class imbalances, smaller database sizes, etc. It also highlights development of novel pattern recognition and machine learning methods specific to medical and genomic data, which is extremely necessary but highly challenging. The book will be useful for healthcare professionals who have access to interesting data sources but lack the expertise to use data mining effectively.

Senescence, Senotherapeutics and Mitochondria
Senescence, Senotherapeutics and Mitochondria

Author:

Publisher: Elsevier

Published: 2023-07-14

Total Pages: 480

ISBN-13: 0443188874

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Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more. Updates on how mitochondria are closely related to the survival of senescent cells using either mitochondria-targeted senolytic or redox modulator senomorphic strategies Differentiates itself from other books with its multidisciplinary perspectives and multidimensional clinical approaches Offers a novel perspective on both the basic and clinical sciences for a wide group of well-established academicians, students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science and nutritional sciences

Biomarkers in Nutrition
Biomarkers in Nutrition

Author: Vinood B. Patel

Publisher: Springer Nature

Published: 2022-10-14

Total Pages: 1173

ISBN-13: 3031073894

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This handbook provides an all-inclusive insight into biomarkers assessing the impact of nutrition on human health. The reader will gain insight into the area of circulating body fluid biomarkers, from cardiovascular related markers to liver functional tests. Various biomarkers related to the intake of micronutrient and macronutrients are presented, and the effects of different diets, pesticide exposure and dietary supplements are discussed, so are changes of genetic, cellular and histological variables. This systematic handbook is a must have for biomedical researchers as well as clinicians and pharmacologists, who wish to gain extensive understanding on the analysis of effects of various nutritional and dietary effects on human health, ageing and longevity.