Modern Therapeutics in Rheumatic Diseases
Modern Therapeutics in Rheumatic Diseases

Author: George C. Tsokos

Publisher: Springer Science & Business Media

Published: 2001-11-08

Total Pages: 648

ISBN-13: 1592592392

DOWNLOAD EBOOK

Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.

Treat to Target in Rheumatic Diseases: Rationale and Results
Treat to Target in Rheumatic Diseases: Rationale and Results

Author: Daniel Aletaha

Publisher: Elsevier Health Sciences

Published: 2019-10-10

Total Pages:

ISBN-13: 0323678971

DOWNLOAD EBOOK

Guest edited by Dr. Daniel Aletaha, this issue of Rheumatic Disease Clinics will cover “Treat to Target in Rheumatic Diseases with a focus on rationale and results. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman. Articles explore diseases, including, but not limited to: History, Rheumatoid Arthritis, Psoriatic Arthritis, Spondylarthropathies, Systemic lupus erythematosus, PMR and GCA, Inflammatory Myopathies (PM/DM), Gout, and Subclinical Targets.

Stem Cell Therapy for Autoimmune Disease
Stem Cell Therapy for Autoimmune Disease

Author: Richard K. Burt

Publisher: CRC Press

Published: 2019-11-11

Total Pages: 1406

ISBN-13: 1000724670

DOWNLOAD EBOOK

Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

The Resolution of Inflammation
The Resolution of Inflammation

Author: Adriano Rossi

Publisher: Springer Science & Business Media

Published: 2008-03-17

Total Pages: 246

ISBN-13: 376437506X

DOWNLOAD EBOOK

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Acute Rheumatic Fever and Rheumatic Heart Disease
Acute Rheumatic Fever and Rheumatic Heart Disease

Author: Dr. Scott Dougherty

Publisher: Elsevier Health Sciences

Published: 2020-02-22

Total Pages: 364

ISBN-13: 0323754600

DOWNLOAD EBOOK

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. - Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. - International editors and chapter authors ensure a truly global perspective. - Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. - Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. - Consolidates today's available information and guidance into a single, convenient resource.

Handbook of Assay Development in Drug Discovery
Handbook of Assay Development in Drug Discovery

Author: Lisa K. Minor

Publisher: CRC Press

Published: 2006-01-20

Total Pages: 490

ISBN-13: 1420015702

DOWNLOAD EBOOK

The Handbook of Assay Development in Drug Discovery describes all the tools currently available for performing various assay techniques. Featuring troubleshooting advice for common problems from experienced assay developers, the vendor community, and scientists in the pharmaceutical industry, the book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. Designed as a guide to running an assay from start to finish, this is an ideal bench top companion for scientists involved in drug discovery screening, lead profiling, therapeutic target evaluation, and assay development and implementation.

Cognitive Science and Artificial Intelligence
Cognitive Science and Artificial Intelligence

Author: Sasikumar Gurumoorthy

Publisher: Springer

Published: 2017-12-22

Total Pages: 112

ISBN-13: 9811066981

DOWNLOAD EBOOK

This book presents interdisciplinary research on cognition, mind and behavior from an information processing perspective. It includes chapters on Artificial Intelligence, Decision Support Systems, Machine Learning, Data Mining and Support Vector Machines, chiefly with regard to the data obtained and analyzed in Medical Informatics, Bioinformatics and related disciplines. The book reflects the state-of-the-art in Artificial Intelligence and Cognitive Science, and covers theory, algorithms, numerical simulation, error and uncertainty analysis, as well novel applications of new processing techniques in Biomedical Informatics, Computer Science and its applied areas. As such, it offers a valuable resource for students and researchers from the fields of Computer Science and Engineering in Medicine and Biology.

Therapeutics in Rheumatology
Therapeutics in Rheumatology

Author: H. A. Bird

Publisher: Springer

Published: 2013-11-11

Total Pages: 566

ISBN-13: 1489928839

DOWNLOAD EBOOK

This book is about the drugs used in the treatment and management of rheumatic disorders. The term 'therapeutics' used in the title is intended to mirror the relevance of drugs in the widest sense of the word. Thus, general principles underlying pharmaceutical and pharmacological study have been included together with more clinical matters concerned with applying specific rheumatic problems. The need for another work on rheumatological drugs in itself, as opposed to the different approach intended, was prompted by the ever continuing and bewildering plethora of antirheumatic drugs flooding the market at present. We believe that such a burgeoning of new preparations is welcome in an era when in general there are still no 'cures' available. Moreover, we also feel that a continued update of this rapidly advancing field is essential, not only for its own sake, but also to place it in perspective with itself and with neighbouring fields.

Dubois' Lupus Erythematosus
Dubois' Lupus Erythematosus

Author: Daniel Jeffrey Wallace

Publisher: Lippincott Williams & Wilkins

Published: 2007

Total Pages: 1516

ISBN-13: 9780781793940

DOWNLOAD EBOOK

Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors—twenty of them new to this edition—provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.