Modern Concepts of Peripheral Nerve Repair
Modern Concepts of Peripheral Nerve Repair

Author: Kirsten Haastert-Talini

Publisher: Springer

Published: 2017-06-19

Total Pages: 144

ISBN-13: 3319523198

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This book focuses on posttraumatic repair and reconstruction of peripheral nerves. Written by internationally respected specialists, it provides an overview of the challenges and the latest advances in diagnosis and treatment of traumatic peripheral nerve injuries. It presents an outline of state-of the-art procedures from diagnostics, including newest imaging techniques, over conventional and alternative surgical approaches to clinical follow-up and rehabilitation, including the latest concepts to improve functional recovery. The purely clinical topics are preceded by neuroanatomical principles and neurobiological events related to peripheral nerve transection injuries and followed by an outlook on current experimental developments in the area of biomaterials for artificial nerve grafts and peripheral nerve tissue engineering. Peripheral nerve injuries not only affect the nerve tissue at the site of injury, but also target tissue and parts of the central nervous system. They often have dramatic consequences for patients, including loss of sensory and motor functions combined with paresthesia or pain, and a reduced quality of life and ability to work. An adequate understanding of the procedures for proper decision-making and reconstructing peripheral nerves is therefore essential to ensure optimized functional recovery.

Peripheral Nerve Tissue Engineering and Regeneration
Peripheral Nerve Tissue Engineering and Regeneration

Author: James B. Phillips

Publisher: Springer

Published: 2022-05-26

Total Pages: 612

ISBN-13: 9783030210519

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This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.

Bioinspired Biomaterials
Bioinspired Biomaterials

Author: Heung Jae Chun

Publisher: Springer

Published: 2021-07-14

Total Pages: 229

ISBN-13: 9789811532603

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This book is the first of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. Topics addressed in this volume, which is devoted to bioinspired biomaterials, range from novel biomaterials for regenerative medicine through to emerging enabling technologies with applications in, for example, drug delivery, maternal–fetal medicine, peripheral nerve repair and regeneration, and brain tumor therapy. New bioinspired hydrogels receive detailed attention in the book, and a further focus is the use of bioinspired biomaterials in the regulation of stem cell fate. Here the coverage includes the role of scaffolds in cartilage regeneration, the bioapplication of inorganic nanomaterials in tissue engineering, and guidance of cell migration to improve tissue regeneration. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

Peripheral Nerve Regeneration
Peripheral Nerve Regeneration

Author: Ana Colette Maurício

Publisher: BoD – Books on Demand

Published: 2017-05-31

Total Pages: 226

ISBN-13: 9535131656

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Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.

Regenerative Medicine and Plastic Surgery
Regenerative Medicine and Plastic Surgery

Author: Dominik Duscher

Publisher: Springer Nature

Published: 2019-11-27

Total Pages: 480

ISBN-13: 3030199622

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This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book’s third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons’ knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

Nerve Surgery
Nerve Surgery

Author: Susan E. Mackinnon

Publisher: Georg Thieme Verlag

Published: 2015-04-15

Total Pages: 1465

ISBN-13: 1638530130

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Representing the treatment and management philosophy of Dr. Susan Mackinnon, Nerve Surgery provides extensive coverage of innovative surgical options as well as guidance on the management of complicated compression neuropathies. In addition to detailed information on tried-and-true as well as cutting-edge surgical techniques, it contains chapters on the basic principles of nerve surgery, such as "Anatomy and Physiology for the Peripheral Nerve Surgeon" and "Evaluation of the Patient with Nerve Injury or Nerve Compression." Key Features: More than 850 compelling full-color figures and photographs demonstrate key concepts Videos narrated by Dr. Mackinnon are available online Coverage of important conditions that can be treated non-operatively, such as neurogenic thoracic outlet syndrome and multilevel compression neuropathy Strategies and secondary procedures for failed nerve surgeries Dr. Mackinnon provides tips on how she manages complicated pain problems This book is a core reference for all plastic surgeons, neurosurgeons, orthopedic surgeons, hand surgeons, residents, and allied health specialists treating patients with nerve injuries.

Extremity Replantation
Extremity Replantation

Author: A. Neil Salyapongse

Publisher: Springer

Published: 2014-11-05

Total Pages: 220

ISBN-13: 1489975160

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Extremity Replantation is a comprehensive text covering all aspects of the upper and lower limb, with an emphasis on state-of-the-art techniques in the surgical and medical management of amputation and avulsion injuries as well as the current understanding of the recovery of function following replantation. It is organized following anatomical zones – thumb, digits, wrist, forearm and elbow; foot, ankle and lower leg – with special chapters dedicated to issues common to all replants, such as complications, medical management, nerve recovery and rehabilitation. Furthermore, the international team of authors demonstrates approaches from the entire spectrum of replantation care specialists, including plastic and reconstructive surgeons, orthopedists, and hand therapists. Generously illustrated with intra-operative photos, this book will serve as a standard reference for orthopedic, reconstructive, plastic, and hand surgeons as well as physicians or ancillary medical staff caring for the replant patient.

Targeted Muscle Reinnervation
Targeted Muscle Reinnervation

Author: Todd A. Kuiken

Publisher: Taylor & Francis

Published: 2013-07-23

Total Pages: 219

ISBN-13: 1439860815

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Implement TMR with Your Patients and Improve Their Quality of LifeDeveloped by Dr. Todd A. Kuiken and Dr. Gregory A. Dumanian, targeted muscle reinnervation (TMR) is a new approach to accessing motor control signals from peripheral nerves after amputation and providing sensory feedback to prosthesis users. This practical approach has many advantage

Manual of Peripheral Nerve Surgery
Manual of Peripheral Nerve Surgery

Author: Mariono Socolovsky

Publisher: Thieme

Published: 2017-11-15

Total Pages: 608

ISBN-13: 3132410012

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Developed and written by top international experts in the field, this lucid new work is a comprehensive yet concise manual for reviewing the basics of peripheral nerve anatomy, pathophysiology, all typical and classic lesions, and the appropriate diagnostics. The chapters culminate in a description of the complex step-by-step surgical repair of these lesions. Succinctly written, the manual covers a range of topics normally only seen in larger works: included are the various plexus systems and associated injuries, facial nerve surgery, compression neuropathies and tumors, gunshot wounds, pain management, and much more. Key Features: Developed and written by members of the World Federation of Neurosurgical Societies (WFNS) Peripheral Nerve Committee Full coverage of all typical nerve lesions from the basics of anatomy and pathophysiology to the most complex surgical solutions Conceived for neurosurgeons, plastic surgeons, orthopaedic surgeons, and hand surgeons, both in training and in professional practice More than 250 images-radiological images, color illustrations, and photographs of dissections-which help in visualizing and comprehending the text better The Manual of Peripheral Nerve Surgery: From the Basics to Complex Procedures is certain to become a much-used reference resource for residents and practicing surgeons alike.