Modelling Protocells

Modelling Protocells

Author: Roberto Serra

Publisher: Springer

Published: 2017-07-24

Total Pages: 191

ISBN-13: 9402411607

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The monograph discusses models of synthetic protocells, which are cell-like structures obtained from non-living matter endowed with some rudimentary kind of metabolism and genetics, but much simpler than biological cells. They should grow and proliferate, generating offsprings that resemble in some way the parent protocells with some variation, so that selection may take place. Sustainable protocell populations have not yet been obtained experimentally and mathematical models are therefore extremely important to address key questions concerning their synthesis and behavior. Different protocell “architectures” have been proposed and high-level abstract models like those that are presented in this book are particularly relevant to gain a better understanding of the different properites. These models are able to treat all the major dynamical phenomena in a unified framework, so they can be seen as “virtual laboratories” for protocell research. Particular attention is paid to the problem of synchronization of the fission rate of the whole protocell and the duplication rate of its "protogenetic" material, which is shown to be an emergent property that spontaneously develops in successive generations. The book is of interest for a broad range of scientists working in soft matter physics, chemistry and biology, interested in the role protocells may play on the development of new technologies with medical, environmental and industrial applications as well as scientists interested in the origin of life.


Protocells

Protocells

Author: Steen Rasmussen

Publisher: MIT Press

Published: 2022-06-07

Total Pages: 723

ISBN-13: 0262545888

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The first comprehensive general resource on state-of-the-art protocell research, describing current approaches to making new forms of life from scratch in the laboratory. Protocells offers a comprehensive resource on current attempts to create simple forms of life from scratch in the laboratory. These minimal versions of cells, known as protocells, are entities with lifelike properties created from nonliving materials, and the book provides in-depth investigations of processes at the interface between nonliving and living matter. Chapters by experts in the field put this state-of-the-art research in the context of theory, laboratory work, and computer simulations on the components and properties of protocells. The book also provides perspectives on research in related areas and such broader societal issues as commercial applications and ethical considerations. The book covers all major scientific approaches to creating minimal life, both in the laboratory and in simulation. It emphasizes the bottom-up view of physicists, chemists, and material scientists but also includes the molecular biologists' top-down approach and the origin-of-life perspective. The capacity to engineer living technology could have an enormous socioeconomic impact and could bring both good and ill. Protocells promises to be the essential reference for research on bottom-up assembly of life and living technology for years to come. It is written to be both resource and inspiration for scientists working in this exciting and important field and a definitive text for the interested layman.


Artificial Life and Evolutionary Computation

Artificial Life and Evolutionary Computation

Author: Marcello Pelillo

Publisher: Springer

Published: 2018-04-02

Total Pages: 326

ISBN-13: 331978658X

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This book constitutes the revised selected papers of the 12th Italian Workshop on Advances in Artificial Life, Evolutionary Computation, WIVACE 2017, held in Venice, Italy, in September 2017.The 23 full papers presented were thoroughly reviewed and selected from 33 submissions. They cover the following topics: physical-chemical phenomena; biological systems; economy and society; complexity; optimization.


Genesis - In The Beginning

Genesis - In The Beginning

Author: Joseph Seckbach

Publisher: Springer Science & Business Media

Published: 2012-03-19

Total Pages: 911

ISBN-13: 9400729413

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Genesis – In The Beginning deals with the origin and diversity of Life and early biological evolution and discusses the question of where (hot or cold sources) and when the beginning of Life took place. Among the sections are chapters dealing with prebiotic chemical processes and considering self-replication of polymers in mineral habitats. One chapter is dedicated to the photobiological regime on early Earth and the emergence of Life. This volume covers the role of symmetry, information and order (homochrial biomolecules) in the beginning of Life. The models of protocells and the genetic code with gene transfer are important topics in this volume. Three chapters discuss the Panspermia hypothesis (to answer “Are we from outer Space?”). Other chapters cover the Astrobiological aspects of Life in the Universe in extraterrestrial Planets of the Solar System and deal with cometary hydrosphere (and its connection to Earth). We conclude with the history and frontiers of Astrobiogy.


The Giant Vesicle Book

The Giant Vesicle Book

Author: Rumiana Dimova

Publisher: CRC Press

Published: 2019-11-19

Total Pages: 652

ISBN-13: 1498752187

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Giant vesicles are widely used as a model membrane system, both for basic biological systems and for their promising applications in the development of smart materials and cell mimetics, as well as in driving new technologies in synthetic biology and for the cosmetics and pharmaceutical industry. The reader is guided to use giant vesicles, from the formation of simple membrane platforms to advanced membrane and cell system models. It also includes fundamentals for understanding lipid or polymer membrane structure, properties and behavior. Every chapter includes ideas for further applications and discussions on the implications of the observed phenomena towards understanding membrane-related processes. The Giant Vesicle Book is meant to be a road companion, a trusted guide for those making their first steps in this field as well as a source of information required by experts. Key Features • A complete summary of the field, covering fundamental concepts, practical methods, core theory, and the most promising applications • A start-up package of theoretical and experimental information for newcomers in the field • Extensive protocols for establishing the required preparations and assays • Tips and instructions for carefully performing and interpreting measurements with giant vesicles or for observing them, including pitfalls • Approaches developed for investigating giant vesicles as well as brief overviews of previous studies implementing the described techniques • Handy tables with data and structures for ready reference


Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery

Author: Juan Bueno

Publisher: Academic Press

Published: 2020-01-22

Total Pages: 194

ISBN-13: 0128189290

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Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. - Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms - Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs - Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies


Artificial Life and Evolutionary Computation

Artificial Life and Evolutionary Computation

Author: Claudio De Stefano

Publisher: Springer Nature

Published: 2023-04-29

Total Pages: 314

ISBN-13: 3031311833

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This book constitutes the refereed proceedings of the 16th Italian Workshop on Artificial Life and Evolutionary Computation, WIVACE 2022, held in Gaeta, Italy, during September 14–16, 2022. The 21 full papers and 3 short papers included in this book were carefully reviewed and selected from 45 submissions. They were organized in topical sections as follows: answer set programming; networks and complex systems, metaheuristics, robotics, and machine learning Chapters 7, 8, and 9 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.


Encyclopedia of Astrobiology

Encyclopedia of Astrobiology

Author: Ricardo Amils

Publisher: Springer

Published: 2021-01-14

Total Pages: 1853

ISBN-13: 9783642278334

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The interdisciplinary field of Astrobiology constitutes a joint arena where provocative discoveries are coalescing concerning, e.g. the prevalence of exoplanets, the diversity and hardiness of life, and its increasingly likely chances for its emergence. Biologists, astrophysicists, biochemists, geoscientists and space scientists share this exciting mission of revealing the origin and commonality of life in the Universe. The members of the different disciplines are used to their own terminology and technical language. In the interdisciplinary environment many terms either have redundant meanings or are completely unfamiliar to members of other disciplines. The Encyclopedia of Astrobiology serves as the key to a common understanding. Each new or experienced researcher and graduate student in adjacent fields of astrobiology will appreciate this reference work in the quest to understand the big picture. The carefully selected group of active researchers contributing to this work and the expert field editors intend for their contributions, from an internationally comprehensive perspective, to accelerate the interdisciplinary advance of astrobiology.


Synthetic Aesthetics

Synthetic Aesthetics

Author: Alexandra Daisy Ginsberg

Publisher: MIT Press

Published: 2014-02-28

Total Pages: 372

ISBN-13: 026201999X

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As synthetic biology transforms living matter into a medium for making, what is the role of design and its associated values?