Modeling the Psychopathological Dimensions of Schizophrenia
Modeling the Psychopathological Dimensions of Schizophrenia

Author: Mikhail Pletnikov

Publisher: Academic Press

Published: 2015-11-05

Total Pages: 550

ISBN-13: 012801184X

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Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader's understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. - Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models - Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia - Edited and authored by leading researchers in the field of schizophrenia and related psychoses

Cognitive Impairment in Schizophrenia
Cognitive Impairment in Schizophrenia

Author: Philip D. Harvey

Publisher: Cambridge University Press

Published: 2013-01-24

Total Pages: 341

ISBN-13: 1107013208

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Provides state-of-the-art information about cognition in schizophrenia with a wide ranging focus on measuring and treating cognitive deficits.

Psychotic Disorders
Psychotic Disorders

Author: Carol A. Tamminga MD

Publisher: Oxford University Press

Published: 2020-10-20

Total Pages: 400

ISBN-13: 0190653299

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Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis--one of the most fascinating manifestations of altered brain behavior--that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this volume comprehensively reviews, critiques, and integrates available knowledge on the etiology, mechanisms, and treatments of psychotic disorders, and outlines ways forward in both research and clinical practice towards more objective, mechanistically-based definitions of psychotic disorders. Chapters address topics such as psychosis phenomenology, biomarkers and treatments, the overlaps and interfaces between psychiatric disorders within the psychosis dimension, and novel disease definitions. Furthermore, the volume incorporates findings on potential mechanisms, bridges between various system levels (i.e., genetic, epigenetic, molecular and cellular, brain circuit and function, psychological, social, environmental and cultural) and their interactions, as well as the potential role in causation and/or mediation in psychotic disorders. Finally, the volume outlines a broad array of treatment approaches, from the readily available (e.g., psychopharmacology, various modalities of psychotherapy) to the experimental (e.g., cognitive interventions, neuromodulation). With a concluding section of forward perspectives conjecturing future directions and related challenges, this book aspires to stimulate new knowledge, generate novel frameworks, and carry new directions forward on psychotic disorders.

One Century of Karl Jaspers' General Psychopathology
One Century of Karl Jaspers' General Psychopathology

Author: Giovanni Stanghellini

Publisher:

Published: 2013-07-04

Total Pages: 345

ISBN-13: 019960925X

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2013 sees the centenary of Jaspers' foundation of psychopathology as a science with the publication of his magnum opus the Allgemeine Psychopathologie (General Psychopathology), Many of the issues concerning methodology and diagnosis are today the subject of much discussion and debate. This volume brings together leading psychiatrists and philosophers to discuss the impact of this volume, its relevance today, and the legacy it left.

Dimensional Psychopathology
Dimensional Psychopathology

Author: Massimo Biondi

Publisher: Springer

Published: 2018-05-30

Total Pages: 307

ISBN-13: 3319782029

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This book presents an innovative approach to clinical assessment in psychiatry based on a number of psychopathological dimensions with a presumed underlying pathophysiology, that are related to fundamental phenomenological aspects and lie on a continuum from normality to pathology. It is described how the evaluation of these dimensions with a specific, validated rapid assessment instrument could easily integrate and enrich the classical diagnostic DSM-5 or ICD-10 assessment. The supplemental use of this dimensional approach can better capture the complexity underlying current categories of mental illness. The findings from a large patient sample suggest how this assessment could give a first glance at how variable and multifaceted the psychopathological components within a single diagnostic category can be, and thereby optimise diagnosis and treatment choices. Being short and easy to complete, this dimensional assessment can be done in a busy clinical setting, during an ordinary psychiatric visit, and in an acute clinical context, with limited effort by a minimally trained clinician. Therefore, it provides interesting and useful information without additional costs, and allows research work to be performed even in difficult settings.

The Epidemiology of Schizophrenia
The Epidemiology of Schizophrenia

Author: Robin M. Murray

Publisher: Cambridge University Press

Published: 2009-10-01

Total Pages: 0

ISBN-13: 9780521121026

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An international team of leading researchers and clinicians provides the first comprehensive, epidemiological overview of this multi-faceted and still-perplexing disorder. Controversial issues such as the validity of discrete or dimensional classifications of schizophrenia and the continuum between psychosis and 'normality' are explored in depth. Separate chapters are devoted to topics of particular relevance to schizophrenia such as suicide, violence and substance abuse. Finally, new prospects for treatment and prevention are considered.

Madness Explained
Madness Explained

Author: Richard P Bentall

Publisher: Penguin UK

Published: 2003-06-05

Total Pages: 656

ISBN-13: 0141909323

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Today most of us accept the consensus that madness is a medical condition: an illness, which can be identified, classified and treated with drugs like any other. In this ground breaking and controversial work Richard Bentall shatters the myths that surround madness. He shows there is no reassuring dividing line between mental health and mental illness. Severe mental disorders can no longer be reduced to brain chemistry, but must be understood psychologically, as part of normal behaviour andhuman nature. Bentall argues that we need a radically new way of thinking about psychosis and its treatment. Could it be that it is a fear of madness, rather than the madness itself, that is our problem?

Re-Visioning Psychiatry
Re-Visioning Psychiatry

Author: Laurence J. Kirmayer

Publisher: Cambridge University Press

Published: 2015-07-29

Total Pages: 725

ISBN-13: 1107032202

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Revisioning Psychiatry brings together new perspectives on the causes and treatment of mental health problems. The contributors emphasize the importance of understanding experience and explore how the brain, the person, and the social world interact to give rise to mental health problems as well as resilience and recovery.

Lived Time
Lived Time

Author: EUGENE. MINKOWSKI

Publisher:

Published: 2019-06-17

Total Pages: 344

ISBN-13: 9780810140608

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Eugène Minkowski's Lived Time articulates a phenomenology of time that is as inspired by the philosophical writings of Henri Bergson and Edmund Husserl as it is by the psychiatric descriptions of Eugen Bleuler. After providing a phenomenological description of the experience of time in normal life, Minkowski considers a number of mental illnesses, including schizophrenia, manic depression, and dementia, and he attempts to show that these pathological cases can be characterized in terms of a distortion of lived time and space. First published in French in 1933 as Le temps vécu, this edition of this classic work of phenomenological psychiatry and psychopathology includes a new foreword by Dan Zahavi that presents some of Minkowski's main ideas and discusses his contemporary relevance.

Personality and Psychopathology
Personality and Psychopathology

Author: Robert F. Krueger

Publisher: Guilford Publications

Published: 2013-10-17

Total Pages: 415

ISBN-13: 1462514847

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Traditionally, personality and psychopathology have been distinct areas of inquiry. This important volume reviews influential research programs that increasingly bridge the gap between the two areas. Presented are compelling perspectives on whether certain personality traits or structures confer risks for mental illness, how temperament interacts with other influences on psychological adaptation, links between personality disorders and mood and anxiety disorders, implications for effective intervention, and more.