Metchnikoff and the Origins of Immunology

Metchnikoff and the Origins of Immunology

Author: Alfred I. Tauber

Publisher: Oxford University Press

Published: 1991-07-25

Total Pages: 276

ISBN-13: 019534510X

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This fascinating intellectual history is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory that phagocytic cells actively defend the host body against pathogens and diseased cells. His program developed from comparative embryological studies that sought to establish genealogical relations between species at the dawn of the Darwinian revolution. In this scientific biography, Tauber and Chernyak explore ore Metchnikoff's development as an embryologist, showing how it prepared him to propose his theory of host-pathogen interaction. They discuss the profound impact of Darwin's theory of evolution on Metchnikoff's progress, and the influence of 19th century debates on vitalism, teleology, and mechanism. As a case study of scientific discovery, this work offers lucid insight into the process of creative science and its dependence on cultural and philosophic sources. Immunologists and historians of science and medicine will find it an absorbing and accessible account of a remarkable individual.


Immunity

Immunity

Author: Luba Vikhanski

Publisher: Chicago Review Press

Published: 2016-04-01

Total Pages: 258

ISBN-13: 1613731132

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Around Christmas of 1882, while peering through a microscope at starfish larvae in which he had inserted tiny thorns, Russian zoologist Elie Metchnikoff had a brilliant insight: what if the mobile cells he saw gathering around the thorns were nothing but a healing force in action? Metchnikoff's daring theory of immunity—that voracious cells he called phagocytes formed the first line of defense against invading bacteria—would eventually earn the scientist a Nobel Prize, shared with his archrival, as well as the unofficial moniker "Father of Natural Immunity." But first he had to win over skeptics, especially those who called his theory "an oriental fairy tale." Using previously inaccessible archival materials, author Luba Vikhanski chronicles Metchnikoff's remarkable life and discoveries in the first moder n biography of this hero of medicine. Metchnikoff was a towering figure in the scientific community of the early twentieth century, a tireless humanitarian who, while working at the Pasteur Institute in Paris, also strived to curb the spread of cholera, syphilis, and other deadly diseases. In his later years, he startled the world with controversial theories on longevity, launching a global craze for yogurt, and pioneered research into gut microbes and aging. Though Metchnikoff was largely forgotten for nearly a hundred years, Vikhanski documents a remarkable revival of interest in his ideas on immunity and on the gut flora in the science of the twenty-first century.


A History of Immunology

A History of Immunology

Author: Arthur M. Silverstein

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 445

ISBN-13: 0080925839

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This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. - A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved - Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye - The only complete history of immunology available


A History of Medical Bacteriology and Immunology

A History of Medical Bacteriology and Immunology

Author: W. D. Foster

Publisher: Butterworth-Heinemann

Published: 2014-05-20

Total Pages: 253

ISBN-13: 1483162451

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A History of Medical Bacteriology and Immunology provides the account of the history of bacteriology from the year 1900 to 1938. This book presents details about the discovery of the important pathogenic bacteria of man, of how they were shown to be causally related to disease, and of the use of these discoveries in the diagnosis, treatment, and prevention of disease. Other topics discussed include the development of the germ theory of infectious diseases; contribution of Louis Pasteur and Robert Koch to medical bacteriology; and discovery of the more important human pathogenic bacteria. This text also discusses the scientific basis and practical application of immunology to medicine; main developments in bacteriology during the early 20th century; and chemotherapy of bacterial disease. This medically oriented text is beneficial for students and individuals conducting study on medical bacteriology and immunology.


Immunity

Immunity

Author: Alfred I. Tauber

Publisher: Oxford University Press

Published: 2017

Total Pages: 329

ISBN-13: 0190651245

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Machine generated contents note: -- Preface -- Acknowledgements -- Introduction -- Chapter 1: A History of the Immune Self -- Chapter 2: Whither Immune Identity? -- Chapter 3: Individuality Revised -- Chapter 4: Immune Cognition -- Chapter 5: Eco-immunology -- Chapter 6: A New Biology? -- Epilogue -- Endnotes -- References. 650


The Generation of Diversity

The Generation of Diversity

Author: Alfred I. Tauber

Publisher: Harvard University Press

Published: 2000

Total Pages: 532

ISBN-13: 9780674001824

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This book is an intellectual history of the major theoretical problem in immunology and its resolution in the post-World War II period. In recent years immunology has been one of the most exciting--and successful--fields of biomedical research; this book provides essential background for understanding the conceptual conflicts occurring in the field.


The Immune Self

The Immune Self

Author: Alfred I. Tauber

Publisher: Cambridge University Press

Published: 1994

Total Pages: 370

ISBN-13: 9780521574433

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The Immune Self is the first extended philosophical critique of immunology.


Life of Elie Metchnikoff, 1845-1916

Life of Elie Metchnikoff, 1845-1916

Author: Olga Metchnikoff

Publisher: Legare Street Press

Published: 2023-07-18

Total Pages: 0

ISBN-13: 9781020494819

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This compelling biography offers a detailed look at the life and work of Elie Metchnikoff, a pioneering biologist who made many important contributions to the field of immunology. Written by Metchnikoff's wife, Olga Mechnikova, this book provides a fascinating glimpse into Metchnikoff's personal and professional life, including his groundbreaking research on the immune system. A must-read for anyone interested in the history of science and medicine. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.


Paul Ehrlich's Receptor Immunology

Paul Ehrlich's Receptor Immunology

Author: Arthur M. Silverstein

Publisher: Elsevier

Published: 2001-11-17

Total Pages: 231

ISBN-13: 0080538517

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Paul Ehrlich's Receptor Immunology: The Magnificent Obsession describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field. - The selectionist theory of antibody formation - Kinetics of primary and secondary antibody response - Quantitative methods of measurement of antigens and antibody - Demonstration of passive transfer of immunity from mother to foetus