Chinmedomics
Chinmedomics

Author: Xijun Wang

Publisher: Academic Press

Published: 2015-07-15

Total Pages: 408

ISBN-13: 0128031182

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Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. - Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method - Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications - Edited by the leading experts of research related to Chinmedomics

Serum Pharmacochemistry of Traditional Chinese Medicine
Serum Pharmacochemistry of Traditional Chinese Medicine

Author: Xijun Wang

Publisher: Academic Press

Published: 2016-12-27

Total Pages: 380

ISBN-13: 0128111488

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Serum Pharmacochemistry of Traditional Chinese Medicine: Technologies, Strategies and Applications provides a valuable and indispensable guide on the latest methods, research advances, and applications in this area. Chapters offer cutting-edge information on pharmacokinetics and pharmacodynamics, analytical chemistry, traditional medicine, natural products, bioinformatics, new technologies, therapeutic applications, and more. For researchers and students in academia and industry, this book provides a hands-on description of experimental techniques, along with beneficial guidelines to help advance research in the fields of Traditional Chinese Medicine and drug development. - Provides a valuable guide for practitioners of serum pharmacochemistry of Traditional Chinese Medicine, along with insights to its current use and future applications - Edited and written by leading scientists at the forefront of this research - Presents well written chapters that include an introduction, description of the method, and identification of chemical constituents, with applications and references to the latest research and literature

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines
Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines

Author: Aihua Zhang

Publisher: John Wiley & Sons

Published: 2021-08-20

Total Pages: 292

ISBN-13: 3527835741

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Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

Traditional Chinese Medicine: Organ Vascular Injury - Volume II
Traditional Chinese Medicine: Organ Vascular Injury - Volume II

Author: Jing-Yan Han

Publisher: Frontiers Media SA

Published: 2024-07-25

Total Pages: 346

ISBN-13: 2832552056

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Organ vascular injury is the basis of multiple organ damage. which is a complex pathological process with multiple mechanisms and links among mechanisms contributing to the disease. To cope much management often focuses a single drug on a single target which is frequently not entirely effective. Chinese medicine with a long traditional history extending more than 2000 years is a medical system that applies multiple ingredients associated with the resolution of complex disease problems. Numerous compounded Chinese medicines have shown very desirable effects on organ vascular injury related disease in clinical use. For example, a number of studies over the past decades has revealed a positive protective and therapeutic effect of compounded Chinese medicines and their major ingredients on Ischemia reperfusion-induced microcirculatory dysfunction and tissue injury in the heart, brain, liver, intestine, and lungs. These compounded medications contain diverse bioactive components with demonstrated ability to target energy metabolism; possess antioxidant effects; inhibit inflammatory cytokine release; alter adhesion molecule expression in leukocytes, platelets, and vascular endothelial cells; and the protect against thrombosis, albumin leakage, and mast cell degranulation.

Understanding Traditional Chinese Medicine
Understanding Traditional Chinese Medicine

Author: Friedrich G. Wallner

Publisher: Peter Lang Gmbh, Internationaler Verlag Der Wissenschaften

Published: 2009

Total Pages: 0

ISBN-13: 9783631567098

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This volume presents texts written by Austrian and Chinese experts in the field of Traditional Chinese Medicine. The issue the authors worked on is the basic problem how to make a different system of medical thinking plausible for the Western world, especially for Western medicine. This issue is considered from different viewpoints - from the viewpoint of Western medicine that is familiar with Chinese medicine and contrariwise from the viewpoint of Chinese Medicine that is familiar with its Western counterpart and from a philosophical viewpoint. In this way both differences in the theoretical systems of Western and Chinese medicine and problems of adequate translation are profundly discussed.

Metabolome Analysis
Metabolome Analysis

Author: Silas G. Villas-Boas

Publisher: John Wiley & Sons

Published: 2007-02-16

Total Pages: 339

ISBN-13: 047010550X

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Providing information on the main approaches for the analysis of metabolites, this textbook: Covers basic methodologies in sample preparation and separation techniques, as well as the most recent techniques of mass spectrometry. Differentiates between primary and secondary metabolites. Includes four chapters discussing successful metabolome studies of different organisms. Highlights the analytical challenges of studying metabolites. Illustrates applications of metabolome analysis through the use of case studies.

Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis
Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

Author: George G. Harrigan

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 342

ISBN-13: 1461503337

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It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.