Metabolic Phenotyping of Uncoupling Protein-3 Knockout Mice
Author: Pierre Flandin-Bléty
Publisher:
Published: 2004
Total Pages: 324
ISBN-13:
DOWNLOAD EBOOKRead and Download eBook Full
Author: Pierre Flandin-Bléty
Publisher:
Published: 2004
Total Pages: 324
ISBN-13:
DOWNLOAD EBOOKAuthor: Pierre Flandin-Bléty (biologiste.)
Publisher:
Published: 2004
Total Pages: 324
ISBN-13:
DOWNLOAD EBOOKLa protéine découplante-3 (UCP3) appartient à la famille des transporteurs mitochondriaux. Cette protéine du muscle squelettique découple la phosphorylation oxydative en dissipant le gradient de proton. La fonction physiologique d'UCP3 reste cependant à déterminer. Les données de la littérature suggèrent un rôle dans l'oxydation des acides gras, dans la régulation du niveau de stress oxydatif, ou dans la dépense énergétique. Afin de comprendre la fonction d'UCP3, nous avons généré des souris déficientes en cette protéine (UCP3KO). L'étude du métabolisme des souris UCP3KO indique que l'UCP3 ne joue pas un rôle essentiel dans l'homéostasie glucido-lipidique. Les changements d'expression d'UCP3 suggèrent que cette protéine n'a pas pour fonction de réguler le niveau de stress oxydatif. En revanche, la mesure de la dépense énergétique des souris UCP3KO traitées avec l'hormone thyroïdienne (triiodothyronine) révèle qu'UCP3 intervient dans l'effet activateur des hormones thyroïdiennes sur la dépense énergétique. Ce résultat suggère qu'UCP3 favorise la dissipation d'énergie.
Author: Giovanni Natile
Publisher: MDPI
Published: 2018-03-05
Total Pages: 177
ISBN-13: 3038427578
DOWNLOAD EBOOKThis book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS
Author: Thomas Seyfried
Publisher: John Wiley & Sons
Published: 2012-05-18
Total Pages: 482
ISBN-13: 1118310306
DOWNLOAD EBOOKThe book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Author: Gerhard Heldmaier
Publisher: Springer Science & Business Media
Published: 2000-08-07
Total Pages: 568
ISBN-13: 9783540674108
DOWNLOAD EBOOKThis book gives an up-to-date account of the current knowledge of cold adaptation in animals, including phenomena like hibernation, daily torpor, thermoregulation and thermogenesis, metabolic regulation, freeze tolerance, anaerobiosis, metabolic depression and related processes. For the next four years - until the 12th International Hibernation Symposium - it will serve as a state-of-the-art reference source for every scientist and graduate student working in these areas of physiology and zoology.
Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
Published: 2011
Total Pages: 309
ISBN-13: 1615041230
DOWNLOAD EBOOKThe endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author: Sabzali Javadov
Publisher:
Published: 2020-09-04
Total Pages: 434
ISBN-13: 9783039363841
DOWNLOAD EBOOKMitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.
Author: William C. Copeland
Publisher: Springer Science & Business Media
Published: 2008-02-04
Total Pages: 415
ISBN-13: 1592592848
DOWNLOAD EBOOKMutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Each readily reproducible protocol includes step-by-step instructions, tips on avoiding pitfalls and extending the method to other situation, and introductory material explaining the theory behind the process. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial dysfunction and disease.
Author: Neale Ridgway
Publisher: Elsevier
Published: 2015-07-24
Total Pages: 625
ISBN-13: 0444634495
DOWNLOAD EBOOKBiochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic
Author: Charles V. Mobbs
Publisher: Karger Medical and Scientific Publishers
Published: 2007
Total Pages: 207
ISBN-13: 380558170X
DOWNLOAD EBOOKDietary restriction uniquely and robustly increases maximum lifespan and greatly reduces age-related diseases in many species, including yeast, flies, nematodes, and mammals. To study mechanisms mediating the protective effects of dietary restriction, the