Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.
Tremor represents one of the most common movement disorders worldwide. It affects both sexes and may occur at any age. In most cases, tremor is disabling and causes social difficulties, resulting in poorer quality of life. Tremor is now recognized as a public health issue given the aging of the population. Tremor is a complex phenomenon that has attracted the attention of scientists from various disciplines. Tremor results from dynamic interactions between multiple synaptically coupled neuronal systems and the biomechanical, physical, and electrical properties of the external effectors. There have been major advances in our understanding of tremor pathogenesis these last three decades, thanks to new imaging techniques and genetic discoveries. Moreover, significant progress in computer technologies, developments of reliable and unobtrusive wearable sensors, improvements in miniaturization, and advances in signal processing have opened new perspectives for the accurate characterization and daily monitoring of tremor. New therapies are emerging. In this book, we provide an overview of tremor from pathogenesis to therapeutic aspects. We review the definitions, the classification of the varieties of tremor, and the contribution of central versus peripheral mechanisms. Neuroanatomical, neurophysiological, neurochemical, and pharmacological topics related to tremor are pointed out. Our goals are to explain the fundamental basis of tremor generation, to show the recent technological developments, especially in instrumentation, which are reshaping research and clinical practice, and to provide up-to-date information related to emerging therapies. The integrative transdisciplinary approach has been used, combining engineering and physiological principles to diagnose, monitor, and treat tremor. Guidelines for evaluation of tremor are explained. This book has been written for biomedical engineering students, engineers, researchers, medical students, biologists, neurologists, and biomedical professionals of any discipline looking for an updated and multidisciplinary overview of tremor. It can be used for biomedical courses. Table of Contents: Introduction / Anatomical Overview of the Central and Peripheral Nervous System / Physiology of the Nervous System / Characterization of Tremor / Prinipal Disorders Associated with Tremor / Quantification of Tremor / Mechanisms of Tremor / Treatments
Your days spent fruitlessly scouring textbooks and websites for credible vet information are over! Now you can get the whole story — the accurate story — all in one place. Introducing The Textbook of Veterinary Internal Medicine, Expert Consult, 8th Edition. Still the only comprehensive resource for veterinary internal medical problems, this faculty-and-student-favorite offers unparalleled coverage of pathophysiology, diagnosis, and disease treatments for dogs and cats. In addition to new chapters and discussions on the industry’s most topical issues, this "gold standard in vet medicine" comes with hundreds of original videos, algorithms, and learning tools to really bring all the information to life. There’s no better source to help you unlock the secrets of veterinary medicine than Ettinger’s! Fully searchable online text offers quick access to the most trusted information in the field. Complete library of over 500 original clinical videos you can believe in. Instead of fruitless YouTube searches, each video expertly breaks down veterinary procedures and important signs of diseases and disorders that are difficult or impossible to understand from written descriptions alone. In-depth coverage of timely issues includes expert explanations on topics such as the genome, clinical genomics, euthanasia, innocent heart murmurs, hyperbaric medicine, home prepared and raw diets, obesity, botulism, artificial pacing of the heart, and cancer vaccines. Thousands of references accessible from the printed book with the click of a QR code. 256 all-new client information sheets can be downloaded, customized, and printed as client handouts. 214 new and updated clinical algorithms aid in disease identification and decision-making. Exclusive access to Expert Consult Online website offers the complete library of original video clips, heart sounds, the full collection of client information sheets, and hyperlinking of references to their source abstracts in PubMed. NEW! In-depth coverage of the latest information and trends in small animal internal medicine. Completely new section on minimally-invasive interventional procedures includes techniques for treating respiratory, cardiovascular, gastrointestinal, urologic/nephrologic, and neoplastic disorders. 17 new chapters address the major clinicopathologic abnormalities that occur in canine and feline laboratory testing. Completely new section on management of mutually-antagonistic comorbidities spotlights concurrent cardiac and renal disease, concurrent infection in patients requiring immunosuppression, and concurrent diabetes mellitus and corticosteroid-dependent disease. Expert explanations on topics such as evidence-based medicine, distinguishing behavioral disorders from medical neurologic disorders, blood transfusion techniques, hyperadrenocorticism (Cushing’s disease), chronic kidney disease, respiratory and inhalant therapy, and many more.
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Veterinary Medicine**Now Ettinger's trusted, all-in-one veterinary resource is even better! Trusted by small animal veterinarians for more than 50 years, Ettinger's Textbook of Veterinary Internal Medicine adds new content on the field's leading issues and trends to its unmatched, "gold standard" coverage of the diagnosis and treatment of medical problems of dogs and cats. Coverage begins with the basics of veterinary medicine, followed by sections on differential diagnosis for chief complaints and for clinicopathologic abnormalities, and continues with techniques, minimally invasive interventional therapies, critical care, toxicology, diseases by body system, and comorbidities. Clinical information is presented in a way that reflects the practitioner's thought process. With each purchase of this two-volume print book, Ettinger's includes access to a fully searchable eBook featuring more than 750 videos that bring procedures to life. - UNIQUE! 50th anniversary edition of this classic textbook. - NEW! Coverage of the latest information and trends includes epilepsy, aerodigestive disorders, patient triage and stabilization, enteric protozoal diseases, pulmonary thromboembolism, point-of-care ultrasounds, immunodeficiencies, and more. - More than 750 original clinical videos are included with purchase of the print book, providing content you can believe in. Forget those time-consuming searches on YouTube, as each video expertly breaks down veterinary procedures and important signs of diseases and disorders that are difficult or impossible to understand from written descriptions alone. - NEW! PDFs in Techniques chapters include a printable pull list of the equipment and materials needed for specific techniques, along with check boxes (accessed through eBook included with print purchase). - eBook version is included with purchase of the print book, allowing you to access all the text, figures, and references, with the ability to search, customize content, make notes and highlights, and have content read aloud. The eBook also offers the complete collection of original video clips, heart sounds, client information sheets, and hyperlinking of references to their source abstracts in PubMed®. - NEW! Additional new material is included on nutritional cardiomyopathy, coronavirus infections, host-microbial interactions in gastrointestinal health, and autonomic nervous system disorders. - More than 200 clinical algorithms aid in disease identification and decision-making. - Fully searchable online text offers quick access to the most important, newest, and relevant veterinary information. - More than 250 client information sheets are available in the eBook (included with print purchase) with short, easy-to-understand clinical descriptions of conditions, diagnostics, and treatment options; these pages may be downloaded, customized, and printed as client handouts. - Thousands of references for the printed book are accessible online. - Expert contributors from around the world provide practical insight into the latest advances and issues affecting small animal medicine.
The Cerebellum: Disorders and Treatment, Volume 155 updates readers on the latest and clinically relevant advances in the study of cerebellar diseases in children and adults. It is organized into sections detailing: (1) Disorders (starting from the fetal cerebellum, to adult cerebellum) encountered during daily practice, and (2) Therapy (including insights into innovative drug and rehabilitative approaches). The book's innovative structure discusses cerebellar disorders in children and adults as a continuum, with its companion volume, The Cerebellum: From Embryology to Diagnostic Investigations detailing embryology, anatomy, function and diagnostic investigations and neuroimaging, including conventional sequences, diffusion tensor imaging, functional MRI, and connectivity studies. - Provides an in-depth understanding of the cerebellum and its involvement in a wide variety of diseases - Explores long-term outcome data of pediatric cerebellar diseases and potential problems in adult life for patients with pediatric cerebellar diseases - Features chapters co-authored by two experts, combining expertise in both pediatric and adult cerebellar diseases
Tremor represents one of the most common movement disorders worldwide. It affects both sexes and may occur at any age. In most cases, tremor is disabling and causes social difficulties, resulting in poorer quality of life. Tremor is now recognized as a public health issue given the aging of the population. Tremor is a complex phenomenon that has attracted the attention of scientists from various disciplines. Tremor results from dynamic interactions between multiple synaptically coupled neuronal systems and the biomechanical, physical, and electrical properties of the external effectors. There have been major advances in our understanding of tremor pathogenesis these last three decades, thanks to new imaging techniques and genetic discoveries. Moreover, significant progress in computer technologies, developments of reliable and unobtrusive wearable sensors, improvements in miniaturization, and advances in signal processing have opened new perspectives for the accurate characterization and daily monitoring of tremor. New therapies are emerging. In this book, we provide an overview of tremor from pathogenesis to therapeutic aspects. We review the definitions, the classification of the varieties of tremor, and the contribution of central versus peripheral mechanisms. Neuroanatomical, neurophysiological, neurochemical, and pharmacological topics related to tremor are pointed out. Our goals are to explain the fundamental basis of tremor generation, to show the recent technological developments, especially in instrumentation, which are reshaping research and clinical practice, and to provide up-to-date information related to emerging therapies. The integrative transdisciplinary approach has been used, combining engineering and physiological principles to diagnose, monitor, and treat tremor. Guidelines for evaluation of tremor are explained. This book has been written for biomedical engineering students, engineers, researchers, medical students, biologists, neurologists, and biomedical professionals of any discipline looking for an updated and multidisciplinary overview of tremor. It can be used for biomedical courses. Table of Contents: Introduction / Anatomical Overview of the Central and Peripheral Nervous System / Physiology of the Nervous System / Characterization of Tremor / Prinipal Disorders Associated with Tremor / Quantification of Tremor / Mechanisms of Tremor / Treatments
Tremors, Volume 163 in the International Review in Neurobiology serial highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review on Neurobiology serial - Updated release includes the latest information on Tremors
Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The seventh volume of this series features reviews that cover the following topics related to the treatment of neurodegenerative diseases, epilepsy and stroke: -Fatty Acid Amides as a New Potential Therapeutic Agent in Multiple Sclerosis -Epileptic Seizures Detection Based on Non-Linear Characteristics Coupled with Machine Learning Techniques -Hampering Essential Tremor Neurodegeneration in Essential Tremor: Present and Future Directions -The Potential Therapeutic Role of the Melatoninergic System in Treatment of Epilepsy and Comorbid Depression -Modeling Neurodegenerative Diseases Using Transgenic Model of Drosophila -Genetic Basis in Stroke Treatment: Targets of Potent Inhibitors
Essentials of the Cerebellum and Cerebellar Disorders is the first book of its kind written specifically for graduate students and clinicians. It is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. This monograph makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from ataxia clinics and cerebellar laboratories throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.
