Measuring Cell Mechanics

Measuring Cell Mechanics

Author: Margaret Gardel

Publisher: Biota Publishing

Published: 2015-09-01

Total Pages: 77

ISBN-13: 1615046992

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Cells are inherently physical entities that both experience mechanical forces from their external environment and generate their own internal forces to drive cell motion. Our particular aim here is to present the reader with an introduction to the primary tools used to measure these mechanical interactions and the material properties of cells that result from them. These approaches can be applied to a diverse array of physiological processes and systems, providing important insight into the regulatory roles of mechanical interactions in cells. We cover techniques at both the molecular and cellular scales, including those that actively and passively probe the system. Along the way we cover the fundamental principles of each approach, while emphasizing the relevant length and timescales, along with the typical magnitudes of the measurements that can be made. Each section ends by highlighting uses of the various techniques in recent relevant publications, illustrating the exciting future of cell mechanics in quantitative cell biology research.


Cytoskeletal Mechanics

Cytoskeletal Mechanics

Author: Mohammad R. K. Mofrad

Publisher: Cambridge University Press

Published: 2006-09-04

Total Pages: 231

ISBN-13: 1139458108

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This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors come from the biophysics, bioengineering and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is the hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.


Introduction to Cell Mechanics and Mechanobiology

Introduction to Cell Mechanics and Mechanobiology

Author: Christopher R. Jacobs

Publisher: Garland Science

Published: 2012-11-16

Total Pages: 350

ISBN-13: 1135042659

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Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical prope


Cell Mechanics

Cell Mechanics

Author: Yu-Li Wang

Publisher: Academic Press

Published: 2007-07-05

Total Pages: 629

ISBN-13: 0080548709

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Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions Includes highly significant topics relevant to basic and translational research, as well as tissue engineering Emphasizes mechanical input and output of cells


Mechanics of the Cell

Mechanics of the Cell

Author: David H. Boal

Publisher: Cambridge University Press

Published: 2012-01-19

Total Pages: 623

ISBN-13: 0521113768

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New edition exploring the mechanical features of biological cells for advanced undergraduate and graduate students in physics and biomedical engineering.


Cellular Mechanics and Biophysics

Cellular Mechanics and Biophysics

Author: Claudia Tanja Mierke

Publisher: Springer Nature

Published: 2020-10-30

Total Pages: 919

ISBN-13: 3030585328

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This book focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It introduces and explains state-of-the-art biophysical methods and examines the role of mechanical properties in the cell/protein interaction with the connective tissue microenvironment. The book presents a unique perspective on cellular mechanics and biophysics by combining the mechanical, biological, physical, biochemical, medical, and immunological views, highlighting the importance of the mechanical properties of cells and biophysical measurement methods. The book guides readers through the complex and growing field of cellular mechanics and biophysics, connecting and discussing research findings from different fields such as biology, cell biology, immunology, physics, and medicine. Featuring suggestions for further reading throughout and addressing a wide selection of biophysical topics, this book is an indispensable guide for graduate and advanced undergraduate students in the fields of cellular mechanics and biophysics.


Cell and Matrix Mechanics

Cell and Matrix Mechanics

Author: Roland Kaunas

Publisher: CRC Press

Published: 2014-10-23

Total Pages: 370

ISBN-13: 1466553820

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Explores a Range of Multiscale Biomechanics/Mechanobiology ConceptsCell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forc


Cytoskeletal Mechanics

Cytoskeletal Mechanics

Author: Mohammad R. K. Mofrad

Publisher:

Published: 2006

Total Pages: 244

ISBN-13: 9781107164253

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This book presents views on approaches to modeling cell mechanics. The diversity of opinions stems from the different backgrounds of those who have contributed to the field. The authors come from the biophysics, bioengineering, and physical chemistry communities, and each joins the discussion with their unique perspective on biological systems.


Viscoelastic Solids (1998)

Viscoelastic Solids (1998)

Author: Roderic S. Lakes

Publisher: CRC Press

Published: 2017-11-22

Total Pages: 476

ISBN-13: 1351355643

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Viscoelastic Solids covers the mathematical theory of viscoelasticity and physical insights, causal mechanisms, and practical applications. The book: presents a development of the theory, addressing both transient and dynamic aspects as well as emphasizing linear viscoelasticity synthesizes the structure of the theory with the aim of developing physical insight illustrates the methods for the solution of stress analysis problems in viscoelastic objects explores experimental methods for the characterization of viscoelastic materials describes the phenomenology of viscoelasticity in a variety of materials, including polymers, metals, high damping alloys, rock, piezoelectric materials, cellular solids, dense composite materials, and biological materials analyzes high damping and extremely low damping provides the theory of viscoelastic composite materials, including examples of various types of structure and the relationships between structure and mechanical properties contains examples on the use of viscoelastic materials in preventing and alleviating human suffering Viscoelastic Solids also demonstrates the use of viscoelasticity for diverse applications, such as earplugs, gaskets, computer disks, satellite stability, medical diagnosis, injury prevention, vibration abatement, tire performance, sports, spacecraft explosions, and music.