Computer Methods for Tolerance Design
Computer Methods for Tolerance Design

Author: Robert G. Wilhelm

Publisher: World Scientific

Published: 1992

Total Pages: 170

ISBN-13: 9789810210588

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This book describes recent research advances and computer tools that can be applied in the determination of geometric tolerances. A framework for tolerance synthesis is developed and used with artificial intelligence techniques to provide computer methods for both analysis and synthesis of geometric tolerance specifications. Tolerance primitives, based on a sound theory of tolerancing, are used to represent tolerance relationships or links between geometric entities and functional requirements. Algorithms are developed for the determination of boundedness and the measurement of sufficiency. A detailed constraint network is used to represent tolerance relations for a part under design and provide for the composition of tolerance specifications.

Margins of Tolerance
Margins of Tolerance

Author: Eric Sasson

Publisher: Livingston Press (AL)

Published: 2012

Total Pages: 0

ISBN-13: 9781604890938

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The characters in ¿Margins of Tolerance¿ are journeying. On vacation, in transit, or in flux, they seek to discover their place, within and outside of their relationships, while learning to navigate their way through a minefield of challenges both external and internal. These gripping tales, some riotously funny, others heart-wrenching, give us a broad picture of the state of gay identity in the cultural kaleidoscope of the 21st century.

Rift-lines within european regulatory framework for biosimilars when taking heterogeneity and variation during lifecycle of the reference biologic and the biosimilar into account
Rift-lines within european regulatory framework for biosimilars when taking heterogeneity and variation during lifecycle of the reference biologic and the biosimilar into account

Author: Malik Osmane

Publisher: Anchor Academic Publishing (aap_verlag)

Published: 2014-02-01

Total Pages: 282

ISBN-13: 3954896877

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Biopharmaceutical medicinal products (biologics) represent a huge financial market. Thus upon patent protection expiry of the innovator (reference) biologic there is interest from industry to gain a portion of this market by launching a 'similar' biologic at a reduced development cost, thus boosting potential gains. The EMA responded to this desire and lead the guidance process with industry on the topic of biosimilars. Based on the experience gained with biosimilars in the past, the EMA started to introduce a second generation series of guidance documents, which take into account the past, current and possibly future challenges of biosimilars. Those proposals were evaluated by EMA and partially incorporated into new guidance documents. This work highlights the challenges and risks associated with biosimilar submissions for large and complex bio-molecules such antibodies. Results: There are unaddressed questions for the regulator with regard to the unsolved dynamic of heterogeneity and variations of the quality profile, which have potential implications on safety and efficacy. This is neglected and not taken into account seriously enough by the stakeholders. Solution: Further, the only (in my view) progressive way to deal with such foreseeable situations from the biosimilar developer’s point of view is to incorporate a design space.

Spaces of Tolerance
Spaces of Tolerance

Author: Igea Troiani

Publisher: Routledge

Published: 2021-03-29

Total Pages: 246

ISBN-13: 1000369528

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Spaces of Tolerance addresses the topic of tolerance in architectural production. Through examining the boundaries of where discourses, practices and designs are considered publishable (suitable to be made public) or not, the book exposes criteria and cultures which censor architecture so as to offer ways that architecture can be more inclusive and diverse for society at large. The contributors to the book discuss: disciplinary tolerances and constraints related to architecture and its interdisciplinary exchanges and modes of working; physical, spatial, temporal and digital tolerance in material assemblages and production between drawing and building; and social, cultural and political tolerance and threats contingent on geography and history. This timely book aims to look at extremities, margins and marginality to explore acceptable levels – and their fluctuations – in deviation and divergence. Chapters in the book involve ungendering, unacculturating (in disciplinary terms) and diversifying the architectural practitioner, writer, editor, reviewer, and reader, and retooling the instruments and tactics of architectural practice and theory. They argue that tolerance in interdisciplinary research in architecture can cultivate more diverse and productive conversations. The chapters in this book were originally published as a special issue of the journal Architecture and Culture.

Research in the History of Economic Thought and Methodology
Research in the History of Economic Thought and Methodology

Author: Luca Fiorito

Publisher: Emerald Group Publishing

Published: 2024-01-19

Total Pages: 178

ISBN-13: 1804559326

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Research in the History of Economic Thought and Methodology (RHETM) is a book series dedicated to an interdisciplinary approach to a broad range of topics related to the history and methodology of economics.

Your Nostradamus Factor
Your Nostradamus Factor

Author: Ingo Swann

Publisher: Swann-Ryder Productions, LLC

Published: 2018-09-02

Total Pages: 342

ISBN-13: 1949214974

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You Can Predict the Future Throughout the centuries the future has been seen in dreams, in visions, and by seers. But you don't have to be a prophet or a visionary to predict what the future holds. Now, Ingo Swann explains how to understand and use the future-predicting ability that lies within. He identifies the different ways the future is revealed: Spontaneous forewarnings during dreams Spontaneous alerts that happen when awake Forewarnings and alerts communally experienced by numbers of people while sleeping or while awake Consciously controlled future-seeing achieved by seers Ingo Swann also presents fascinating, documented examples of prophecies that came true, ranging from those that foresaw the sinking of the Titanic to his own prediction of the fall of the Berlin Wall. Your Nostradamus Factor explains how you can develop your ability to foresee the future by: • Overcoming blocks to future-seeing • Tracking a particular subject and testing your predictions • Using astrology to help see the future, and • Paying close attention to your dreams. With the millennium right around the corner, Swann also offers startling predictions for the future of the environment, the economy, science, and society. (originally published in 1993)

Trends in Statistical Codicology
Trends in Statistical Codicology

Author: Marilena Maniaci

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2021-11-22

Total Pages: 827

ISBN-13: 3110743876

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The application of statistical techniques to the study of manuscript books, based on the analysis of large data sets acquired through the archaeological observation of manuscripts, is one of the most original trends in codicological research, aiming not only to reconstruct on a sound basis the methods and processes used in book manufacture and their tendential evolution in space and time, but also to interpret them as the result of a dynamic interplay between various and often incompatible needs (of cultural, technical, social and economic nature) that book artisans had to reconcile in the best possible way. The present collection of essays in English translation was guided by the desire to offer a multifarious well-articulated picture of the application of statistical methodology to the various aspects of manuscript production, namely analysis of materials, characterization of book types, manufacturing techniques, planning and use of layout characterization of scripts and scribal habits. The volume aims to present to a wider readership a series of significant papers which have appeared over the last fifteen years, by means of which the statistical approach continues to demonstrate its vast potential.