Essential Biochemistry, 3rd Edition is comprised of biology, pre-med and allied health topics and presents a broad, but not overwhelming, base of biochemical coverage that focuses on the chemistry behind the biology. Furthermore, it relates the chemical concepts that scaffold the biology of biochemistry, providing practical knowledge as well as many problem-solving opportunities to hone skills. Key Concepts and Concept Review features help students to identify and review important takeaways in each section.
Using an integrated strategic management process to explain what organisations should do to increase strategic competitiveness and achieve higher performance, the 4th Asia Pacific edition of Strategic Management: Competitiveness and Globalisation continues to provide a systematic skill-building coverage of strategy. With an emphasis on global advantage, the text offers a comprehensive examination of regional and international issues to provide a complete, accurate and up-to-date explanation of the strategic management process. New coverage on environmental concerns and emerging technologies as well as examples and cases from Australia, New Zealand and Asia-Pacific serve to engage students while updated international content demonstrates how strategic management is used in the global economy. Recognising the importance of relating theory to practice, Strategic Management: Competitiveness and Globalisation 4e provides 13 new case studies and a raft of online cases supported by a case matrix.
"Pratt's essential biochemistry, global edition aims to provide a solid foundation in biochemistry, presenting complete, up-to-date information while focusing on the practical aspects of biochemistry as it applies to human health, nutrition and disease. It presents a broad, but not overwhelming coverage of basic biochemical concepts that focus on the chemistry behind biology, structure-function relationships, transformation of energy and how genetic information is stored and made accessible. It relates these concepts to practical knowledge as well as providing many problem-solving opportunities to enhance skills."--Page 4 de la couverture.
Base your leadership development programs on proven-to-work techniques. In Building Leaders, authors Conger and Benjamin examine the very best practices of American and foreign companies to present a comprehensive plan for developing leadership talent at every organizational level. Here, readers will find an in-depth presentation of the specific skill sets that individual managers need in order to lead. They'll also discover which organizational values promote leadership, examine successful strategic interventions, and see what a successful leadership plan looks like. Equally illuminating is the section on plans that are destined to fail, along with the section on the future of leadership that shows readers how to design development programs that are most likely to last.
For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which mutations or environmental stresses may result in a partial misfolding that leads then to alternative conformations capable of disturbing cellular processes. This may happen by self-association (aggregation), as in prion and Alzheimer’s diseases, or by incorporation of alternatively folded subunits into structural entities, as in collagen diseases. Another possibility is that folding to the native structure is impaired or abolished, resulting in decreased stea- state levels of the correctly folded protein, as is observed in cystic fibrosis and 1-antitrypsin deficiency, as well as in many enzyme deficiencies. In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological phenotypes. Examples of this are the spastic paraplegia attributable to mutations in mitochondrial protease/chaperone complexes.
