Mammary Tumorigenesis and Malignant Progression
Mammary Tumorigenesis and Malignant Progression

Author: Robert B. Dickson

Publisher: Springer

Published: 1994-07-31

Total Pages: 384

ISBN-13:

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The current volume represents the fourth over a period of five years in our series on Advances in the Cellular and Molecular Biology of Breast Cancer. The first three volumes were entitled Breast Cancer: Cellular and Molecular Biology, Regulatory Mechanisms in Breast Cancer, and Genes, Oncogenes, and Hormones, respectively. Throughout this series, we have tried to take a broad look at cutting-edge topics in basic science research into breast cancer. This attempt has resulted in a wide range of subject material, including rodent and human model systems, oncogenes, suppressor genes, growth factors, hormones, tumor-host interactions, and determinants of metastases. Since our last volume, research in breast cancer has continued to proceed at an explosive rate. We hope the current volume will provide the reader with some of the excitement felt by the editors and authors as we begin to understand this all-too-common disease. The first section of this book is devoted to the basic processes of proli feration, differentiation, and malignant progression of breast cancer. T.l. Anderson and W.R. Miller lead off with a detailed description of controls on proliferation in the normal human breast and in breast cancer. This chapter strongly emphasizes pathological aspects. The second chapter, by M.R. Stampfer and P. Yaswen, presents a corresponding viewpoint through a presentation of experiments with human mammary epithelial cells in culture. The second section of the book emphasizes the genetic basis for breast cancer onset and malignant progression. Chapter 3, by M.-C. King and S.

Mammary Tumor Cell Cycle, Differentiation, and Metastasis
Mammary Tumor Cell Cycle, Differentiation, and Metastasis

Author: Robert B. Dickson

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 432

ISBN-13: 1461312590

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Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who study rodent models of the disease and to those who study the cellular and molecular basis of human breast cancer. The first section of the book is devoted to new mouse models of mammary development and tumorigenesis. The second section moves to studies of human breast cancer and focuses on receptors, signalling, and the cell cycle. The final section deals with defective tissue interactions in human breast cancer. We are now in a period of extremely rapid accumulation of data on the molecular and cellular biology of breast cancer. These findings are highlighted in chapters from Mammary Tumor Cell Cycle, Differentiation and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer.

Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine

Author: Robert C. Bast, Jr.

Publisher: John Wiley & Sons

Published: 2017-03-10

Total Pages: 2004

ISBN-13: 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response
Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

Author: Hans E. Kaiser

Publisher: Springer Science & Business Media

Published: 2008-05-20

Total Pages: 251

ISBN-13: 1402067291

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The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It contains state-of-the-science reviews on invasion, metastasis, angiogenesis, apoptosis and immunologic aspects related to cancer.

Circulating Tumor Cells in Breast Cancer Metastatic Disease
Circulating Tumor Cells in Breast Cancer Metastatic Disease

Author: Roberto Piñeiro

Publisher: Springer Nature

Published: 2020-04-17

Total Pages: 177

ISBN-13: 3030358054

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This book is aimed to summarise the key aspects of the role of circulating tumour cells (CTCs) in breast cancer, with special attention to their contribution to tumour progression and establishment of metastatic disease. We aim to give a clear overview of the knowledge about CTCs, framed in the context of breast cancer, by analysing basic and clinical research carried out so far. In a broader sense, we will address what are the main clinical needs of this disease based on its molecular heterogeneity (subtypes) and lay out the knowledge and understanding that CTCs are giving about it and how they are contributing and can still improve the better monitoring and management of breast cancer patients. We will discuss the evidences of the use of CTCs as a tool to monitor cancer progression and therapy response, based on the prognostic and predictive value they have, as well as a tool to unravel mechanisms of resistance to therapy and to identify new biomarkers allowing to predict therapy success. Moreover, we will analyse the main aspects of ongoing clinical trials and how they can contribute to determine the clinical utility of CTCs as a breast cancer biomarker. We will also touch upon general knowledge or basic notions of the biology of the metastatic process in epithelial cancers, in order to understand the origin and biology of CTCs. In this sense, we will pay special attention to EMT (epithelial to mesenchymal transition), dormancy and minimal residual disease, three key aspects that determine the outcome of the disease. We will also cover general aspects on the isolation and characterization techniques applies to the study of CTCs, and also the possibilities that the study of CTCs, as a biomarker with biological function, is opening in terms of understanding the biology of metastatic cells and the identification of therapeutic targets based on the functional and molecular characterization of CTCs. Lastly, we will try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine.

Breast Cancer: Scientific and Clinical Progress
Breast Cancer: Scientific and Clinical Progress

Author: Marvin A. Rich

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 407

ISBN-13: 1461317533

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Effective control of breast cancer depends on three types of research accomplishment -- understanding the disease's origins and progression: successfully applying this knowledge to methods of detection, diagnosis and treatment: and finding ways to make these advances truly available to the public as effectively as possible. The significant progress that is occurring across this entire spectrum of pioneering investigation is reflected in these proceedings of the 1987 biennial conference of the International Association for Breast Cancer Research. The first section of the book focuses on oncogenes and chemical effectors that may play key roles in early cell transformation leading to breast cancer. Research discussed includes identification of specific oncogenes which appear to be involved in the disease, study of their activation and expression, examination of the biological effects of various growth factors isolated from breast cancer cell lines, and investigation of the molecular mechanisms by which estrogens promote and stimulate growth of breast cancers. The second group of chapters deals with several other complex factors and phenomena which may influence tumor formation in the breast, for example, expression of abnormalities by fibroblasts, disruption of epithelial-mesenchymal interactions, and loss of ability nili to synthesize normal basal lamina resulting in alterations in the extracellular matrix. Clarification of the processes of normal mammary gland development and differentiation is central to much of this work.

The Role of E2f5 in Mammary Gland Development and Breast Cancer Progression
The Role of E2f5 in Mammary Gland Development and Breast Cancer Progression

Author: Briana To

Publisher:

Published: 2020

Total Pages: 129

ISBN-13:

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Dysregulation of mammary developmental processes have resulted in breast cancer development and progression. Thus, understanding normal mammary gland development is critical to understanding how cancer cells are initiated and maintained. Transcriptomic profiling of various mammary gland developmental phases, including virgin, pregnancy, lactation and involution, revealed distinct gene expression patterns associated at each stage. Pathway analysis predicted a role for transcription factors E2F1-4 during different stages of development. The importance of E2Fs in mammary development was confirmed by the defects observed in the mammary glands of mice deficient for various E2Fs. To examine if compensation occurs among activator E2Fs in the mammary gland, we analyzed mammary gland development in double E2F knockout mice. Our analysis revealed that compensation does occur among activator E2Fs in the mammary gland. However, this compensation appears to be very specific, as E2F2 can compensate for E2F1 but not E2F3 loss. Although the role of E2F1-4 has been characterized in mammary gland development, little is known about E2F5, an E2F demonstrating repressor activity. Using bioinformatic analysis, we predicted a role for E2F5 in terminal end bud differentiation and developmental stages. To further examine the role of E2F5 in normal mammary gland development, we generated a mammary-specific E2F5 knockout mouse model (E2F5CKO). Analysis of mammary gland development in E2F5CKO mice reveal only modest mammary gland defects. However, we found that E2F5CKO animals develop mammary tumors after a prolonged latency. Using transcriptomic profiling, we identified oncogenes that are dysregulated in E2F5CKO tumors, potentially contributing to tumorigenesis. Through these studies, we have identified a novel role of E2F5 as a tumor suppressor in breast cancer and further elucidated roles of E2Fs in mammary gland development.