Malignant Pleural Mesothelioma: Present Status and Future Directions
Malignant Pleural Mesothelioma: Present Status and Future Directions

Author: Tommaso Claudio Mineo

Publisher: Bentham Science Publishers

Published: 2016-02-04

Total Pages: 536

ISBN-13: 1681081938

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Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually increasing among the global human population. Mesothelioma prognosis in patients is usually poor and their life expectancy is significantly reduced. This edited monograph presents holistic information about malignant mesothelioma in one volume. Readers will gain knowledge of the etiology, immunopathology of this disease and will understand the rationale for new treatment methods. The initial section of the book gives the historical context of mesothelioma in medicine. Subsequent sections illustrate mesothelioma epidemiology with respect to the problem of asbestos diffusion in different areas of the world such as Europe, The Americas, East Asia, Australia and Africa. This is followed by chapters detailing current information about asbestos and non-asbestos molecular biology and etiopathogenesis, as well as intriguing insights from human genetics and translational medicine. Other sections in this volume focus on clinical information; mesothelioma diagnosis and staging are thoroughly described with a focus on serum biomarkers and pleural liquid cytology. Additional sections provide information on treatment modalities, with one section dedicated to surgical procedures. Malignant Pleural Mesothelioma: Present Status and Future Directions is a comprehensive informational resource with well organized sections, aided by protocol charts, tables and figures. The book is essential for both medical oncology students and specialists who want to augment or update their knowledge about this neoplasm.

Malignant Pleural Mesothelioma
Malignant Pleural Mesothelioma

Author: Robert F. Diegelmann

Publisher:

Published: 2016-02-04

Total Pages:

ISBN-13: 9781681081946

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"Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually increasing among the global human population. Mesothelioma"

Malignant Pleural Mesothelioma
Malignant Pleural Mesothelioma

Author: Takashi Nakano

Publisher: Springer Nature

Published: 2021-02-05

Total Pages: 352

ISBN-13: 981159158X

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This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma. Significant progress has been made in understanding mesothelioma biology, and in developing new therapies for this refractory tumor, malignant pleural mesothelioma (MPM). Not only does this volume summarize the latest research-based data on the disease; it also shares insights into future research directions. The book consists of 5 themed sections on: epidemiology, pathogenesis, screening and early detection, molecular genetics, and clinical aspects and management. Several chapters focus on new trends in the field, e.g. immune therapy and identification of biomarkers, molecular oncogenesis including genetic susceptibility, and molecular diagnostic pathology. The book also highlights new cancer treatment approaches, such as immunotherapy based on immune checkpoint inhibitors, which has meant a paradigm shift in other types of cancer, and given some hope to MPM patients. In turn, it discusses recent molecular pathological studies on mesothelioma, which claim to offer more accurate classifications than traditional morphology and immunohistochemistry-based approaches. All of these cutting-edge analyses provide the basis for a closing discussion on future developments and research directions. Malignant Pleural Mesothelioma - Advances in Pathogenesis, Diagnosis, and Treatments has been edited and authored by respected researchers and will be of interest to medical, surgical and radiation oncologists; pulmonologists; pathologists and basic researchers alike. Since the disease represents a significant diagnostic and therapeutic challenge, scientists and clinicians from learners to experts, as well as fellows in training in these subspecialties, will value this book.

Malignant Pleural Mesothelioma
Malignant Pleural Mesothelioma

Author: Ken O'Byrne

Publisher:

Published: 2006

Total Pages: 475

ISBN-13: 0198529309

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This book provides health professionals and scientists with a comprehensive overview of the mesothelioma - an asbestos induced malignancy. It includes chapters on epidemology, diagnosis, histopathology, radiology, surgery, chemotherapy, immune therapy, and radiotherapy as well as the molecular biology and future therapies.

Occupational Cancers
Occupational Cancers

Author: Sisko Anttila

Publisher: Springer Nature

Published: 2020-02-10

Total Pages: 641

ISBN-13: 3030307662

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This revised and updated new edition of a successful book is a multidisciplinary, comprehensive guide to occupational factors of malignant diseases. Building on the first edition, new research discoveries and their consequences in our understanding on carcinogenic mechanisms, diagnosis and attribution of occupational cancers are discussed. Examples of such discoveries are germline and acquired mutations of BAP1 in malignant mesothelioma, which have led to changes in diagnostic criteria, and carcinogen-specific genetic and epigenetic alterations in lung cancer. There are several new chapters, including gastrointestinal cancers, epidemiology of lung cancer, cancer of thyroid, and the role of primary health care in occupational cancer control. Occupational Cancers is aimed at experienced and trainee oncologists, pathologists, clinicians in occupational health, and pulmonologists, as well as epidemiologists, clinical researchers, lawyers and public health officials.

Asbestos and Mesothelioma
Asbestos and Mesothelioma

Author: Joseph R. Testa

Publisher: Springer

Published: 2017-04-06

Total Pages: 403

ISBN-13: 3319535609

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This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases. Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance. Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.

Asbestos
Asbestos

Author: Michele Carbone

Publisher: CRC Press

Published: 2024-08-21

Total Pages: 427

ISBN-13: 1040105599

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Asbestos: Risk Assessment, Epidemiology, and Health Effects offers a key text on the evolving information regarding asbestos and human health. Now in its third edition, this bestseller explores the pathological complexities of asbestos-related disease and examines how asbestos induces diseases in biological systems. The book also discusses the types of instruments and methods available for evaluation of the content of asbestiform minerals in products, air, water, surface areas, and tissue. It explains the relevance of each of these applications and gives readers the tools to evaluate data in the future. Edited by leading authorities on the subject and with contributions from a team of international experts, this book takes a cross-disciplinary approach and an authoritative review of the history, pathology, epidemiology, sampling, and analysis of asbestos. Backed up with photos and numerous diagrams, tables, and photographs, it features case studies, methodologies, and sampling/analytical schemes that put learning into context. Fully up-to-date and featuring four brand new chapters covering asbestosis and immunity, asbestos litigation and surgical and non-surgical management of mesothelioma, this book remains the most comprehensive source of information on asbestos and the only guide the reader will ever need to own. This essential text will appeal to any professional at any level who requires the latest expertise in dealing with asbestos. It suits researchers and practitioners alike, as well as those in the fields of law, health, education, hospitality, emergency response, building management and maintenance, construction, safety, insurance, and industrial hygiene.

Mesothelioma
Mesothelioma

Author: Giovanni Luca Ceresoli

Publisher: Springer

Published: 2019-06-19

Total Pages: 341

ISBN-13: 3030168840

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This book offers an updated review of malignant mesothelioma, including the latest advances in our understanding of its genetic control and molecular biology, as well as pre-clinical and clinical research. It also presents state-of-the-art diagnostic approaches and therapeutic options, and an open discussion on the future prospects for patient management. Malignant mesothelioma is an enormous global health problem related to asbestos exposure. Despite the best efforts of scientists and oncologists, the prognosis for those affected remains poor. Due to anatomical characteristics and non-specific symptoms, the diagnosis of mesothelioma at an early stage is often difficult, while surgery and radiotherapy are only of limited use, even if some multimodality approaches seem promising. In turn, medical treatments are sometimes successful in tumor control, but have little impact on overall survival. However, advances in our understanding of the disease’s biology, together with the availability of new drugs and combinations, make mesothelioma an essential and highly topical field for pre-clinical and clinical studies. This book is subdivided into four parts: epidemiology and preclinical data, diagnosis, therapy, and extrathoracic mesothelioma. It highlights the progress made in a variety of areas – e.g. in vitro and in vivo experimental models, genetics, environment, biomarkers, targeting agents, immunotherapy, metabolic imaging and ongoing clinical trials – and describes the standard clinical management of mesothelioma patients, including those with extra-thoracic localizations. Given its scope, the book offers an invaluable tool for researchers, oncologists and clinicians alike.

Thoracic Tumours
Thoracic Tumours

Author: W. H. O. Classification WHO Classification of Tumours Editorial Board

Publisher:

Published: 2021-04-21

Total Pages: 500

ISBN-13: 9789283245063

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****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** Thoracic Tumoursis the fifth available volume in the fifth edition of the WHO series on the classification of human tumours. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumours and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. What's new in this edition? The fifth edition, guided by the WHO Classification of Tumours Editorial Board, establishes a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumour type listed within a taxonomic classification: site, category, family (class), type, and subtype. In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria. Who should read this book? * Pathologists * Oncologists * Respiratory physicians * Thoracic radiologists * Cancer researchers * Surgeons * Epidemiologists * Cancer registrars This volume: * Prepared by 217 authors and editors * Contributors from around the world * More than 1000 high-quality images * More than 3500 references