Genome Stability
Genome Stability

Author: Igor Kovalchuk

Publisher: Academic Press

Published: 2021-07-17

Total Pages: 762

ISBN-13: 0323856802

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Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. - A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects - Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability - Contains applications of genome instability research and outcomes for human disease - Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Maintenance for Industrial Systems
Maintenance for Industrial Systems

Author: Riccardo Manzini

Publisher: Springer Science & Business Media

Published: 2009-11-09

Total Pages: 479

ISBN-13: 1848825757

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New, global and extended markets are forcing companies to process and manage increasingly differentiated products with shorter life cycles, low volumes and reduced customer delivery times. In today’s global marketplace production systems need to be able to deliver products on time, maintain market credibility and introduce new products and services faster than competitors. As a result, a new production paradigm of a production system has been developed and a supporting management decision-making approach simultaneously incorporating design, management, and control of the production system is necessary so that this challenge can be effectively and efficiency met. "Maintenance Engineering and its Applications in Production Systems" meets this need by introducing an original and integrated idea of maintenance: maintenance for productivity. The volume starts with the introduction and discussion of a new conceptual framework based on productivity, quality, and safety supported by maintenance. Subsequent chapters illustrate the most relevant models and methods to plan, organise, implement and control the whole maintenance process (reliability evaluation models and prediction, maintenance strategies and policies, spare parts management, computer maintenance management software – CMMS, and total productive maintenance – TPM, etc.). Several examples of problems supported by solutions, and real applications to help and test the reader’s comprehension are included. "Maintenance Engineering and its Applications in Production Systems" will certainly be valuable to engineering students, doctoral and post-doctoral students and also to maintenance practitioners, as well as managers of industrial and service companies.

Improving the Efficiency of Engines for Large Nonfighter Aircraft
Improving the Efficiency of Engines for Large Nonfighter Aircraft

Author: National Research Council

Publisher: National Academies Press

Published: 2007-08-30

Total Pages: 193

ISBN-13: 0309103991

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Because of the important national defense contribution of large, non-fighter aircraft, rapidly increasing fuel costs and increasing dependence on imported oil have triggered significant interest in increased aircraft engine efficiency by the U.S. Air Force. To help address this need, the Air Force asked the National Research Council (NRC) to examine and assess technical options for improving engine efficiency of all large non-fighter aircraft under Air Force command. This report presents a review of current Air Force fuel consumption patterns; an analysis of previous programs designed to replace aircraft engines; an examination of proposed engine modifications; an assessment of the potential impact of alternative fuels and engine science and technology programs, and an analysis of costs and funding requirements.

Mastering Amazon Relational Database Service for MySQL
Mastering Amazon Relational Database Service for MySQL

Author: Jeyaram Ayyalusamy

Publisher: BPB Publications

Published: 2024-02-05

Total Pages: 564

ISBN-13: 9355519362

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Toolkit for unlocking the power of Amazon RDS and propelling businesses toward success in the digital age KEY FEATURES ● Explore Amazon RDS by covering basics to advanced MySQL management on the platform. ● Real-world examples and hands-on tutorials to apply gained knowledge to solve challenges. ● Latest features, tools, and best practices in Amazon RDS for MySQL by covering recent developments. DESCRIPTION This book is a valuable resource as a practical guide for professionals involved in managing Amazon Relational Database Service (RDS) instances. The book covers the fundamentals of Amazon RDS, configuration best practices, and optimizing performance. With MySQL databases, it explores essential components, AWS Regions, and Availability Zones. Readers will benefit from the detailed discussions on managing and maintaining Amazon RDS MySQL instances, covering topics like stopping and starting DB instances, optimizing settings, handling maintenance updates, and understanding the nuances of reboots. The book emphasizes security considerations and provides a comprehensive guide to storage management, encryption options, backup strategies, and cost optimization. The later chapters delve into advanced topics such as creating and connecting to MySQL databases on Amazon RDS, managing Multi-AZ MySQL DB clusters, and upgrading AWS RDS MySQL. The book also covers comprehensive monitoring techniques, tools, and insights, offering a thorough exploration of CloudWatch metrics, alarms, and event notifications. Throughout the book, best practices, common issues, and troubleshooting tips are provided, making it an indispensable companion for database administrators navigating the complexities of Amazon RDS for MySQL. WHAT YOU WILL LEARN ● The fundamentals of Amazon RDS and how it simplifies the management of MySQL databases. ● How to set up, configure, and deploy MySQL instances on Amazon RDS. ● Best practices for designing highly available and scalable database architectures. ● Performance optimization techniques to ensure your MySQL databases run efficiently on Amazon RDS. ● Advanced topics such as replication, security, monitoring, and troubleshooting. WHO THIS BOOK IS FOR Whether you are a database administrator, a software developer, a system architect, or a technology enthusiast, this book provides valuable insights and practical guidance for effectively utilizing Amazon RDS. TABLE OF CONTENTS 1. Amazon Relational Database Service 2. Configuring a DB Instance for Amazon RDS MySQL 3. Managing and Maintaining an Amazon RDS MySQL Instance 4. Creating and Connecting to MySQL Database on Amazon RDS 5. Managing Amazon RDS Multi-AZ MySQL DB Clusters 6. Amazon RDS MySQL Backups: Best Practices for Data Integrity and Business Continuity 7. Upgrading AWS RDS MySQL 8. Comprehensive Amazon RDS MySQL Monitoring: Metrics, Tools, and Insights 9. Comprehensive Monitoring Tools for Amazon RDS and AWS Solutions 10. Understanding Amazon RDS Read Replicas: Scaling and High Availability

Maintenance Fundamentals
Maintenance Fundamentals

Author: R. Keith Mobley

Publisher: Elsevier

Published: 2011-03-15

Total Pages: 425

ISBN-13: 0080478980

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No matter which industry a company is a part of, its profitability, like its products, is driven by the reliability and performance of its plant(s). The fundamentals for maintenance found in this volume are applicable to a multitude of industries: power, process, materials, manufacturing, transportation, communication, and many others. This book shows the engineer how to select, install, maintain, and troubleshoot critical plant machinery, equipment, and systems. NEW to this edition: New material includes a chapter on inspections, providing practical guidelines for effective visual inspections, the key to effective preventive maintenance. Also included in the revision will be multiple chapters on equipment, such as pumps, compressors, and fans. - Provides practical knowledge about plant machinery, equipment, and systems for the new hire or the veteran engineer - Covers a wide array of topics, from shaft alignment and bearings to rotor balancing and flexible intermediate drives - Delivers must-have information to the engineer which he/she will use on a daily basis, in day-to-day activities, that will affect the reliability and profitability of the plant