This is the first coherent book on literature-based discovery (LBD). LBD is an inherently multi-disciplinary enterprise. The aim of this volume is to plant a flag in the ground and inspire new researchers to the LBD challenge.
This book constitutes the thoroughly refereed post-workshop proceedings of the workshops that were held in conjunction with the 24th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2020, in Singapore, Singapore, in May 2020. The 17 revised full papers presented were carefully reviewed and selected from a total of 50 submissions. The five workshops were as follows: · First International Workshop on Literature-Based Discovery (LBD 2020) · Workshop on Data Science for Fake News (DSFN 2020) · Learning Data Representation for Clustering (LDRC 2020) · Ninth Workshop on Biologically Inspired Techniques for Data Mining (BDM · 2020) · First Pacific Asia Workshop on Game Intelligence & Informatics (GII 2020)
An examination of the role of libraries in the utilization of knowledge and in enhancing the informed conduct of life incorporates a review of the goals of library use and library services.
An easy-to-follow introduction to support vector machines This book provides an in-depth, easy-to-follow introduction to support vector machines drawing only from minimal, carefully motivated technical and mathematical background material. It begins with a cohesive discussion of machine learning and goes on to cover: Knowledge discovery environments Describing data mathematically Linear decision surfaces and functions Perceptron learning Maximum margin classifiers Support vector machines Elements of statistical learning theory Multi-class classification Regression with support vector machines Novelty detection Complemented with hands-on exercises, algorithm descriptions, and data sets, Knowledge Discovery with Support Vector Machines is an invaluable textbook for advanced undergraduate and graduate courses. It is also an excellent tutorial on support vector machines for professionals who are pursuing research in machine learning and related areas.
In The Discovery of Slowness, German novelist Sten Nadolny recounts the life of the nineteenth-century British explorer Sir John Franklin (1786-1847). The reader follows Franklin's development from awkward schoolboy and ridiculed teenager to expedition leader, governor of Tasmania, and icon of adventure. Everyone with whom he came into contact sensed that he was a rare man, one who was “out of his time” and who moved to a different, grander beat. That beat eventually led Franklin to sail once more—on his final, fateful voyage—into the Arctic in search of the Northwest Passage. The Discovery of Slowness is both a riveting account of a remarkable and varied life, and a profound and thought-provoking meditation on time.
Students who participate in scientific research as undergraduates report gaining many benefits from the experience. However, undergraduate research done independently under a faculty member's guidance or as part of an internship, regardless of its individual benefits, is inherently limited in its overall impact. Faculty members and sponsoring companies have limited time and funding to support undergraduate researchers, and most institutions have available (or have allocated) only enough human and financial resources to involve a small fraction of their undergraduates in such experiences. Many more students can be involved as undergraduate researchers if they do scientific research either collectively or individually as part of a regularly scheduled course. Course-based research experiences have been shown to provide students with many of the same benefits acquired from a mentored summer research experience, assuming that sufficient class time is invested, and several different potential advantages. In order to further explore this issue, the Division on Earth and Life Studies and the Division of Behavioral and Social Sciences and Education organized a convocation meant to examine the efficacy of engaging large numbers of undergraduate students who are enrolled in traditional academic year courses in the life and related sciences in original research, civic engagement around scientific issues, and/or intensive study of research methods and scientific publications at both two- and four-year colleges and universities. Participants explored the benefits and costs of offering students such experiences and the ways that such efforts may both influence and be influenced by issues such as institutional governance, available resources, and professional expectations of faculty. Integrating Discovery-Based Research into the Undergraduate Curriculum summarizes the presentations and discussions from this event.
"Reinventing Discovery argues that we are in the early days of the most dramatic change in how science is done in more than 300 years. This change is being driven by new online tools, which are transforming and radically accelerating scientific discovery"--
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.
Book one of the New York Times bestselling All Souls series, from the author of The Black Bird Oracle. “A wonderfully imaginative grown-up fantasy with all the magic of Harry Potter and Twilight” (People). Look for the hit series “A Discovery of Witches,” now streaming on AMC+, Sundance Now, and Shudder! Deborah Harkness’s sparkling debut, A Discovery of Witches, has brought her into the spotlight and galvanized fans around the world. In this tale of passion and obsession, Diana Bishop, a young scholar and a descendant of witches, discovers a long-lost and enchanted alchemical manuscript, Ashmole 782, deep in Oxford's Bodleian Library. Its reappearance summons a fantastical underworld, which she navigates with her leading man, vampire geneticist Matthew Clairmont. Harkness has created a universe to rival those of Anne Rice, Diana Gabaldon, and Elizabeth Kostova, and she adds a scholar's depth to this riveting tale of magic and suspense. The story continues in book two, Shadow of Night, book three, The Book of Life, and the fourth in the series, Time’s Convert.
Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.